A5077263980- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Carcinogens and Genotoxicity Assessment
- RNA modifications and cancer
- Heat shock proteins research
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Noise Effects and Management
- RNA and protein synthesis mechanisms
- Healthcare Systems and Public Health
- Heavy Metal Exposure and Toxicity
- Indoor Air Quality and Microbial Exposure
- Prenatal Screening and Diagnostics
- Chemokine receptors and signaling
- Climate Change and Health Impacts
- Reproductive Biology and Fertility
- Tryptophan and brain disorders
- Bipolar Disorder and Treatment
- interferon and immune responses
- MicroRNA in disease regulation
- Mental Health Research Topics
- Protein Structure and Dynamics
- NF-κB Signaling Pathways
- Telomeres, Telomerase, and Senescence
- Spinal Cord Injury Research
First Affiliated Hospital of Anhui Medical University
2023-2024
Anhui Medical University
2023-2024
Wuxi Fourth People's Hospital
2021-2024
Jiangnan University
2021-2024
Wuxi Institute of Technology
2024
Shaoxing People's Hospital
2024
Chengdu Center for Disease Control and Prevention
2017-2023
Bridge University
2023
Sun Yat-sen University
2023
Huazhong University of Science and Technology
2011-2018
Polycyclic aromatic hydrocarbons (PAHs) are known to induce reactive oxygen species and oxidative stress, but the dose–response relationships between exposure PAHs stress levels have not been established. In this study, we recruited 1333 male coke oven workers, monitored of environmental PAHs, measured internal PAH biomarkers including 12 urinary metabolites plasma benzo[a]pyrene-r-7,t-8,t-9,c-10-tetrahydotetrol-albumin (BPDE-Alb) adducts, as well two 8-hydroxydeoxyguanosine (8-OHdG)...
Background Air pollution has been associated with an increased risk of cardiopulmonary mortality and decreased heart rate variability (HRV). However, it is unclear whether coke oven emissions (COEs) polycyclic aromatic hydrocarbons (PAHs) are HRV. Objectives Our goal in the present study was to investigate association exposure COEs urinary metabolite profiles PAHs HRV workers. Methods We measured benzene soluble matter, carbon monoxide, sulfur dioxide, particulate matters, at different...
Exposure to environmental polycyclic aromatic hydrocarbons (PAHs) has been associated with increased risk of cancer, but evidence for gender differences in this association is limited. The aim study was examine the PAHs caused early genotoxic effects such as oxidative stress and chromosome damage, which are potential carcinogenic etiology PAHs. A total 478 nonsmoking workers (272 men 206 women) from a coke oven plant were recruited. We determined 16 their workplaces, measured concentrations...
Smoking is a risk factor for many human diseases. DNA methylation has been related to smoking, but genome-wide data smoking in Chinese populations limited.We aimed investigate epigenome-wide relation population.We measured the levels at > 485,000 CpG sites (CpGs) from leukocytes using array and conducted meta-analysis of total 596 participants. We further evaluated associations smoking-related CpGs with internal polycyclic aromatic hydrocarbon (PAH) biomarkers their correlations expression...
All humans are now co-exposed to multiple toxic chemicals, among which metals and polycyclic aromatic hydrocarbons (PAHs) of special concern as they often present at high levels in various human environments. They can also induce similar early health damage, such genetic oxidative stress, heart rate variability (HRV). Exposure metals, PAHs, their combined pollutants alter microRNA (miRNA) expression patterns. To explore the associations metal-PAH co-exposure with miRNA expression, associated...
Background: In clinical practice, antibiotics and/or inhaled or oral hormone preparations are the first line of treatment for chronic pharyngitis. However, this therapeutic regimen is not satisfactory enough. At present, medicinal plants as dietary supplements functional foods widely recognized and prevention different diseases. Purpose: This study aimed to evaluate efficacy botanical lozenge made from several plant extracts in pharyngitis its effects on patients’ illness perception...
We previously identified five polycyclic aromatic hydrocarbons (PAHs)-associated microRNAs (miRNAs) and found they were associated with chromosome damage. As oxidative damage is the common contributory cause of various PAHs-related diseases, we further investigated influences these miRNAs their interactions environmental factors on DNA lipid peroxidation. measured PAHs internal exposure biomarkers [urinary monohydroxy-PAHs (OH-PAHs) plasma...
To investigate the association of bilateral high-frequency hearing loss (BHFHL) with blood pressure and hypertension among occupational noise exposed workers.Occupational workers were enrolled in 2017 from diseases survey Chengdu. BHFHL was classified as normal, mild, or high by tone average. Linear regression model used to assess effects exposure time on pressure. Logistic performed estimate risk odds ratios (ORs) associated BHFHL.Increasing years significantly systolic diastolic increase...
Background: Patients with diabetic foot ulcer (DFU) usually have a poor quality of life (QoL) and self-efficacy, which is affected by many risk factors. However, the role psychological resilience in QoL self-efficacy DFU patients has remained unclear.Methods: This prospective cross-sectional study was performed single center from January 2018 to February 2020. A total 98 were enrolled this study. Some demographic clinical data prospectively collected participants. The participants assessed...
The heat shock protein Hsp70 is crucial for regulating cellular homeostasis in stressed cells. Although the tumorigenic potential and prognostic applications of have been widely investigated, it remains unclear whether genetic variations human isoforms HSPA1L, HSPA1A, HSPA1B are associated with cancer risk prognosis. In this study, we genotyped six tagSNPs these genes 1,152 paired patients lung controls, then validated results additional cohorts 1,781 1,038 controls. addition, evaluated...
We sought to clarify the association of occupational formaldehyde exposure with DNA strand breaks, chromosome damage and DNA-protein crosslinks (DPCs) in peripheral blood (PB) lymphocytes plywood workers.We determined Olive tail moment (OTM) values, micronucleus (MN) frequencies DPC rates PB 178 workers divided into control lower higher groups according their current levels examined each end point number work years. also an additional 62 before after 8-hour for validating association.OTM...
HSPA1A (HSP70-1) is a highly inducible heat shock gene up-regulated in response to environmental stresses and pollutants. The aim of our study was evaluate the sensitivity stable metabolically competent HepG2 cells containing human promoter-driven luciferase reporter (HepG2-luciferase cells) for assessing toxicity organic pollutants present air. HepG2-luciferase were validated by treatment testing three compounds (pyrene, benzo[a]pyrene, formaldehyde) that are ubiquitous maximal level...
Telomere attrition plays a critical role in the reproductive aging process humans. length (TL) is typically regulated by telomerase, main component of which telomerase reverse transcriptase (TERT). The aim present study was to investigate changes relative TL (RTL) and TERT expression granulosa cells (GCs) during its association with reproduction. Clinical data on frozen‑thawed embryo transfer cycles older (>35 year old) younger (≤35 women from single center over 3‑year period were...
Objective: To explore the present situation and epidemiological characteristics of pesticide poisoning in Chengdu City from 2012 to 2021, provide scientific evidence for further prevention control. Methods: In January 2022, report cards 2021 were collected China Disease Control Prevention Information System. The data card was reorganized distribution such as time, region, gender, age types analyzed. Results: 14326 cases reported 651 deaths, fatality rate 4.54%. productive unproductive 504...
<title>Abstract</title> Objective The objective of this study was to explore the factors influencing cumulative live birth rate (CLBR) for couples undergoing preimplantation genetic testing monogenic disorders (PGT-M). Methods This a retrospective cohort involving who underwent PGT-M at our center from January 2017 December 2023. A multivariate logistic regression analysis applied following that may influence CLBR per patient PGT-M: female age, oocytes pick up (OPU) times, category, COH...