A5057228969- Semiconductor materials and devices
- Multiferroics and related materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Radical Photochemical Reactions
- Electronic and Structural Properties of Oxides
- Fluorine in Organic Chemistry
- Extracellular vesicles in disease
- Antibiotic Resistance in Bacteria
- Catalytic C–H Functionalization Methods
- Ferroelectric and Piezoelectric Materials
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Epigenetics and DNA Methylation
- ZnO doping and properties
- Advanced Sensor and Energy Harvesting Materials
- Magnetic and transport properties of perovskites and related materials
- Ferroelectric and Negative Capacitance Devices
- Diamond and Carbon-based Materials Research
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Cyclopropane Reaction Mechanisms
- Nanoplatforms for cancer theranostics
- Thin-Film Transistor Technologies
- Sulfur-Based Synthesis Techniques
Purdue University West Lafayette
2021-2025
East China Normal University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Shandong University of Traditional Chinese Medicine
2022-2025
Ministry of Industry and Information Technology
2024-2025
Nanjing University of Aeronautics and Astronautics
2022-2025
Tsinghua University
2023-2025
Beijing Radiation Center
2023-2025
Shandong Academy of Sciences
2024
Qilu University of Technology
2024
Abstract Surface‐enhanced Raman spectroscopy (SERS) is a promising technology for wearable sensors due to its fingerprint spectrum and high detection sensitivity. However, since SERS‐activity sensitive both the distribution of “hotspots” excitation angle, it profoundly challenging develop SERS sensor with stability under various deformations during movements. Herein, inspired by omnidirectional light‐harvesting compound eye Xenos Peckii, developed using plasmonic nanovoids array (OPNA),...
Stereoselective cyclopropanation reaction of alkenes is usually achieved by metal complexes via singlet-metal-carbene intermediates. However, previous transition-metal-catalyzed with acylsilanes afforded low diastereoselectivity. Herein, we report the first visible-light-induced transition-metal-free terminal trifluoroacetylsilanes and difluoroacetylsilanes. Both aromatic aliphatic as well electron-deficient are suitable substrates for highly cis-selective [2+1] cyclization reaction. A...
Glioblastoma multiforme (GBM) is an aggressive brain tumour which drug treatment has no overall significant effect on survival rate. Sinomenine a natural product extracted from the traditional Chinese medicine Qingteng and was found to have certain anti-tumour effect. Although, its short biological half-life, unstable physicochemical properties, large dosage causes histamine release hindered use but it may form basis for novel therapy of GBM. We designed, synthesised screened sinomenine...
The SERS based method is simple and time saving compared with other methods.
Exosomes are small membrane vesicles secreted by cells and enriched with plenty of proteins. Considering their significant roles in different physical activities potential value for diagnostic drug delivery, researchers have put great efforts vitro tracking content analysis exosomes. Recently, the emergence kinds super-resolution microscopy provides powerful tools exosome study. Here, we demonstrate application single-molecule localization based imaging technique cancer-derived In...
A novel kind of array-assisted surface-enhanced Raman spectroscopy (SERS) microfluidic chip (ArraySERS chip) is demonstrated for gas sensing, which has the advantages both ultrahigh sensitivity and multiplex sensing ability. On one hand, introduction a microstructured triangular array can greatly increase multiple collision probability between molecules interfaces in channel. Compared with traditional sensors using sealed boxes, where gaseous move only by diffusion, ArraySERS exhibits...
Abstract Diamond is the hardest natural material, but its practical strength low and elastic deformability extremely limited. While recent experiments have demonstrated that diamond nanoneedles can sustain exceptionally large tensile strains with high strengths, size- orientation-dependence of these properties remains unknown. Here we report maximum achievable strain various diameters, oriented in <100>, <110> <111> -directions, using situ transmission electron microscopy....
Abstract Isolating and in situ profiling the heterogeneous molecular phenotype of circulating tumor cells are great significance for clinical cancer diagnosis personalized therapy. Herein, an on‐chip strategy is proposed that combines size‐based microfluidic cell isolation with multiple spectrally orthogonal surface‐enhanced Raman spectroscopy (SERS) analysis membrane proteins identification subpopulations. With developed chip, sieved from blood on basis size discrepancy. To enable multiplex...
Gas sensors lie at the heart of various fields ranging from medical to environmental sciences, and demand gas is instantly expanding. However, in face complex samples, how maintain high sensitivity while performing multiplex detection still puzzles researchers. Here, by introducing Ti3C2Tx MXene into a microfluidic sensor with three-dimensional (3D) transferable SERS substrate, powerful having both detecting ability demonstrated. The employ endows universal adsorption efficiency for gases...
Abstract Exosomes are endosome‐derived vesicles enriched in body fluids such as urine, blood, and saliva. So far, they have been recognized potential biomarkers for cancer diagnostics. However, the present single‐variate analysis of exosomes has greatly limited accuracy specificity diagnoses. Besides, most diagnostic approaches focus on bulk using lots tend to be less accurate because vulnerable impure extraction concentration differences exosomes. To address these challenges, a quantitative...
Sustainable construction is widely regarded as one of the best decisions to reduce environmental impact buildings. Numerous scientific efforts have been devoted promoting sustainability by adopting different techniques such life cycle assessment (LCA) and building information modeling (BIM). The recent circular economy (CE) agenda prioritizing in sectors including due increasing concern on materials efficiency resources consumption. Therefore, this study aimed identify implications,...
Carbapenem-resistant, hypervirulent Klebsiella pneumoniae (CR-hvKP) has recently emerged as a significant threat to public health. In this study, 29 K. isolates were isolated from eight patients admitted the intensive care unit (ICU) of comprehensive teaching hospital located in China March 2017 January 2018. Clinical information was basis for further analyses including antimicrobial susceptibility tests, identification antibiotic resistance and virulence gene determinants, multilocus...
Fluorinated fused rings are challenging to construct from simple starting materials. Herein, we report the first photocatalyzed cascade reactions of readily available cyclopropanols and α-trifluoromethyl-substituted olefins for synthesis gem-difluorooxetanes. Two three bonds were efficiently constructed in one reaction. The reaction showed broad substrate scope downstream transformations products demonstrated synthetic potential mechanistic study supported presence photoredox catalysis...
Gem-difluoroalkenes and trifluoromethyl alkanes are pervasive in biologically active molecules. Photo-catalyzed alkylation of α-CF3-olefins provides a straightforward approach to access these scaffolds; however, such strategy is often hampered, gem-difluoroalkenes usually formed instead under reductive quenching-initiated photoredox conditions. It both mechanistically synthetically appealing if simple change the catalyst can chemo-selectively lead either type products. Here, we show...
Finding and exploring non-noble metal-based electrocatalysts for the promising power-to-hydrogen fuel technology through water splitting reactions is highly emerging. Herein, we report preparation of cobalt-based metal-organic frameworks (Co-MOFs) using an oleylamine (OLA) 1-dodecanethiol (DDT)-modified trimesic acid (TMA), cobalt precursor. Then, electrocatalytically active selenides were derived from Co-MOFs by a water-organic solvent mixture-assisted single-step selenization process....
Monofluoroalkenes are nonhydrolyzable mimetics of amides. Previous work focused on the synthesis non-cyclic monofluoroalkenes. However, diastereoselective monofluorocyclohexenes from substrates is challenging. Herein, we report first photocatalyzed cascade cyclization reactions readily available α,β-unsaturated carbonyl compounds and gem-difluoroalkenes for highly functionalized monofluorocyclohexenes. The reaction shows broad substrate scope with high diastereoselectivity (>30 examples, up...
Memristors can be used to mimic synaptic behavior in artificial neural networks, which makes them a key component neuromorphic computing and holds promise for advancing the field. In this study, memory device based on ZnO-BaTiO
Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune functions play vital role in ACS development; however, whether epigenetic modulation contributes to the regulation blood immune cells this disease has not been investigated.We conducted an epigenome-wide analysis with circulating identify differentially methylated genes ACS.We examined genome-wide methylation whole 102 patients and 101 controls using HumanMethylation450 array, externally replicated significant...
Smoking is a risk factor for many human diseases. DNA methylation has been related to smoking, but genome-wide data smoking in Chinese populations limited.We aimed investigate epigenome-wide relation population.We measured the levels at > 485,000 CpG sites (CpGs) from leukocytes using array and conducted meta-analysis of total 596 participants. We further evaluated associations smoking-related CpGs with internal polycyclic aromatic hydrocarbon (PAH) biomarkers their correlations expression...
Background: Aging is related to an increased risk of morbidity and mortality affected by environmental factors. Exposure polycyclic aromatic hydrocarbons (PAHs) associated with adverse health outcomes; but the association such exposure DNA methylation aging, a novel aging marker, unclear. Objectives: Our aim was investigate PAH aging. Methods: We trained validated age predictor suitable for Chinese populations using whole blood data in 989 160 Caucasians. defined two indicators: Δage, as...
Although blinatumomab, a bispecific T cell engaging antibody, exhibits high clinical response rates in patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (B-ALL) and B non-Hodgkin's lymphoma (B-NHL), it still has some limitations because of its short half-life. Mesenchymal stromal cells (MSCs) represent an attractive approach for delivery therapeutic agents to cancer sites owing their tropism towards tumors, but immunosuppression capabilities, especially induced by...