A5082466693- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Mesenchymal stem cell research
- Angiogenesis and VEGF in Cancer
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Cardiac Fibrosis and Remodeling
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Macrophage Migration Inhibitory Factor
- Cytokine Signaling Pathways and Interactions
- Ion channel regulation and function
- Cholesterol and Lipid Metabolism
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Systemic Lupus Erythematosus Research
- Acute Myocardial Infarction Research
- Cell Adhesion Molecules Research
- Cancer-related molecular mechanisms research
- Psoriasis: Treatment and Pathogenesis
- Lipid metabolism and disorders
Yichun University
2024
Riverside Hospital of Guangxi Zhuang Autonomous Region
2024
Huazhong University of Science and Technology
2013-2023
Union Hospital
2012-2023
Union Hospital
2010-2022
Southern Medical University
2018
Wuhan Union Hospital
2012-2015
Zen-Noh (Japan)
2015
Tongji Hospital
2010
Washington University in St. Louis
2010
Background/Aims: Recent studies have shown that circulating microRNAs (miRNAs) are emerging as promising biomarkers for cardiovascular diseases. This study aimed to determine whether miR-19b-3p, miR-134-5p and miR-186-5p can be used novel indicators acute myocardial infarction (AMI). Methods: To investigate the kinetic expression of three selected miRNAs, we enrolled 18 patients with AMI 20 matched controls. Plasma samples were collected from each participant, total RNA was extracted....
Innate immune and inflammatory responses are involved in myocardial ischaemia/reperfusion (I/R) injury. Interleukin (IL)-37 is a newly identified member of the IL-1 family, functions as fundamental inhibitor innate immunity inflammation. However, its role I/R injury remains unknown. or sham operations were performed on male C57BL/6J mice. mice received an injection recombinant human IL-37 vehicle, immediately before reperfusion. Compared with vehicle treatment, treated showed obvious...
More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting IL-37 is involved atherosclerosis-related diseases. However, plasma levels patients with acute syndrome (ACS, including unstable angina pectoris myocardial infarction) have yet to be investigated.Plasma IL-37, IL-18, IL-18BP were measured 50 stable (SAP), 75 (UAP), 67 infarction (AMI), 65 control...
Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune functions play vital role in ACS development; however, whether epigenetic modulation contributes to the regulation blood immune cells this disease has not been investigated.We conducted an epigenome-wide analysis with circulating identify differentially methylated genes ACS.We examined genome-wide methylation whole 102 patients and 101 controls using HumanMethylation450 array, externally replicated significant...
Abstract Thymoquinone (TQ), as the active constituents of black cumin (Nigella sativa) seed oil, has been reported to have potential protective effects on cardiovascular system. This study aimed investigate and underlying mechanisms TQ myocardial ischemia‐reperfusion (I/R) injury in Langendorff‐perfused rat hearts. Wister hearts were subjected I/R experimental group pretreated with prior I/R. Hemodynamic parameters, infarct size, cardiac marker enzymes, superoxide dismutase (SOD),...
Background Accumulating evidence shows that the novel anti-inflammatory cytokine IL-35 can efficiently suppress effector T cell activity and alter progression of inflammatory autoimmune diseases. The two subunits IL-35, EBI3 p35, are strongly expressed in human advanced plaque, suggesting a potential role atherosclerosis coronary artery disease (CAD). However, plasma levels patients with CAD have yet to be investigated. Methods Plasma IL-10, TGF-β1, IL-12 IL-27 were measured using an ELISA...
Our previous study indicated that interleukin (IL)-37 is involved in atherosclerosis. In the present study, Anterior tibial arteries were collected from diabetes patients and controls. A histopathological analysis showed IL-37 was over-expressed human atherosclerotic plaques. Many types of cells including macrophages, vascular smooth muscle (VSMCs), endothelial T lymphocyte expressed ApoE-/- mice divided into a control group recombinant IL-37-treated group. The treatment resulted significant...
BACKGROUND Malvidin (alvidin-3-glucoside) is a polyphenol that belongs to the class of natural anthocyanin, which abundantly found in red wines, colored fruits, and skin grapes. Therefore, current investigation was intended evaluate effect malvidin against myocardial infarction induced by isoproterenol rats. MATERIAL AND METHODS The cardioprotective effects assessed determining on activities endogenous antioxidants - catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH)...
The mobilization of bone marrow (BM) progenitor cells (PCs) is largely governed by interactions between stromal cell-derived factor (SDF)-1 and CXC chemokine receptor (CXCR)4. Ischemic injury disrupts the SDF-1-CXCR4 interaction releases BM PCs into peripheral circulation, where mobilized are recruited to injured tissue contribute vessel growth. can also be pharmacological CXCR4 antagonist AMD3100, but other components signaling pathway unknown. c-kit, a membrane-bound tyrosine kinase for...
Background . CD4+ T helper (Th) cells play critical roles in the development and progression of atherosclerosis onset acute coronary syndromes (ACS, including myocardial infarction (AMI) unstable angina pectoris (UAP)). In addition to Th1, Th2, Th17 cells, Th22 Th9 subsets have been identified humans. present study, we investigated whether are involved ACS. Methods The frequencies were detected using a flow cytometric analysis their related cytokine transcription factor measured AMI, UAP,...
OBJECTIVE Recent genome-wide association studies (GWAS) revealed that a 9p21.3 locus was associated with type 2 diabetes. In this study, we carried out large-scale case-control study in the GeneID Chinese Han population to 1) further replicate of diabetes GWAS single nucleotide polymorphisms (SNPs) and 2) assess these SNPs coronary artery disease. RESEARCH DESIGN AND METHODS Three (rs2383208, rs10811661, rs10757283) were genotyped two cohorts 3,167 individuals. Case-control design used...
Aims . miR‐208a is associated with adverse outcomes in several cardiac pathologies known to have increased apoptosis, including myocardial infarction (MI). We investigated if has proapoptotic effects on ischemic cardiomyocytes and its silencing therapeutic benefits MI. Methods Results The effect of apoptosis during ischemia was studied cultured neonatal mice myocytes transfected agomir or antagomir. Differential gene expression assessed using microarrays. MI induced male C57BL/6 randomly...
Background and Purpose Numerous in vitro studies have suggested that digoxin suppresses inflammation alters lipid metabolism. However, the effect of dioxin on atherosclerosis is poorly understood. The present study was conducted to determine whether affects development a murine model atherosclerotic disease. Experimental Approach Apolipoprotein E‐deficient mice maintained Western‐type diet were administered PBS (control), low‐dose (1 mg·kg −1 · day ) or high‐dose (2 via i.p. injection for 12...
Cardiac fibrosis triggered by pressure overload represents one of the major challenges in treatment cardiovascular diseases. MicroRNA (miRNA/miR)‑155, a member small RNA family, has previously been demonstrated to be associated with cardiac inflammation. However, effect miR‑155 on induced angiotensin II (Ang II), particularly fibroblasts, requires further investigation. The present study aimed investigate Ang II‑induced using animal models and fibroblasts. Animal were established male...
Oxidative stress and subsequent cardiac myocyte apoptosis play central roles in the initiation progression of myocardial ischemia-reperfusion (I/R) injury. Homeobox transcript antisense intergenic RNA ( Hotair ) was previously implicated various heart diseases, yet its role I/R injury has not been clearly demonstrated. Mice with cardiac-restricted knockdown or overexpression were exposed to surgery. H9c2 cells cultured subjected hypoxia/reoxygenation (H/R) stimulation further verify...
The antitumor effect of doxorubicin (DOX) is limited by its acute and chronic toxicity to the heart, which causes heart injury. Heat shock protein 22 (Hsp22) a proved exert anti-apoptosis anti-inflammatory effects in other diseases physical conditions. In this study, we aim explore whether Hsp22 could protective role during cardiac injury response DOX.The overexpression was mediated via adenovirus vector clarify caused DOX. DOX-induced mouse model established single intraperitoneal injection...
This study was to investigate the proliferation and differentiation of rat adipose stromal cells when implanted into ischemic myocardium improvement heart function.Sprague-Dawley tissue digested with collagenase type I solution were derived by culture. The cells' surface phenotype examined flow cytometry. Adipose labeled 4'6-diamidino-2-phenylindole (adipose group) or Dulbecco's modified Eagle medium (control transplanted myocardium, which produced ligation left descending branch coronary...
Abstract Astragalus polysaccharide (APS), the main extract from traditional Chinese medicinal herb membranaceus , has been reported to benefit treatment of immune‐inflammatory diseases and metabolic disorders. In atherosclerotic plaques, proinflammatory cytokines exert adverse effects on lipids thereby aggravating atherosclerosis. Recent evidence shows that tumor necrosis factor‐alpha (TNF‐α) can down‐regulate expression ATP‐binding cassette transporter A1 (ABCA1), which plays a vital role...
Recent evidence demonstrated that the circulating adipokines were associated with onset of acute coronary syndrome (ACS) including unstable angina pectoris (UAP) and myocardial infarction (AMI). As a novel adipokine, chemerin has been related to atherosclerosis presence artery disease. However, plasma levels in patients ACS have yet be investigated. Plasma adiponectin measured by an enzyme-linked immunosorbent assay (ELISA) 60 stable (SAP), UAP, AMI 40 control patients. Left ventricular...
In response to the growing diverse needs of ceramic industry, this paper creatively employs ErgoLAB Human-Machine Environment Synchronization Platform collect eye movement, gaze trajectory, dwell time, and various modalities data including electroencephalographic skin conductance data, thereby identifying core parameters for parametric design. On basis, a design process shapes based on Python programming language has been developed, covering key stages such as parameter selection, shape...
Summary Atherosclerosis is an inflammatory disease in which dendritic cells have been suggested to play essential role. The underlying signalling mechanisms are unknown thus far. family of Toll‐like receptors (TLRs) initiates innate immune responses, and receptor‐4 (TLR4) has considered be important player the initiation progression atherosclerotic disease. highly conserved mitogen‐activated protein kinase (MAPK) one major families that regulate by transducing extracellular into cellular...
Valsartan has a protective effect against hypertension and atherosclerosis in humans experimental animal models. This study aimed to determine the of prolonged treatment with angiotensin II (Ang II) on valsartan activity CD4(+) T lymphocyte subsets. The results showed that (8 wks) exogenous Ang resulted an increased atherosclerotic plaque size switch stable-to-unstable via modulating activity, including increase helper cell type 1 (Th1) Th17 cells decrease Th2 regulatory (Treg) cells. In...