A5103566025- Esophageal Cancer Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Atherosclerosis and Cardiovascular Diseases
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Peripheral Artery Disease Management
- Esophageal and GI Pathology
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Cytokine Signaling Pathways and Interactions
- Cerebrovascular and Carotid Artery Diseases
- Vascular Procedures and Complications
- Cardiac Valve Diseases and Treatments
- Head and Neck Cancer Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Fault Detection and Control Systems
- Gastrointestinal disorders and treatments
- Immune Cell Function and Interaction
Wuhan University
2024-2025
Renmin Hospital of Wuhan University
2024-2025
The First People's Hospital of Shunde
2025
Southern Medical University
2011-2025
Sun Yat-sen University
2009-2025
Sun Yat-sen University Cancer Center
2009-2025
Huaqiao University
2024
Hunan University
2024
Southeast University
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Recent studies have shown that the presence of systemic inflammation correlates with poor survival in various cancers. The aim this study was to determinate prognostic value neutrophil lymphocyte ratio (NLR) and platelet (PLR) patients esophageal squamous cell carcinoma (ESCC).Preoperative NLR PLR were evaluated 483 undergoing esophagectomy for ESCC from January 2005 December 2008. significance both markers then determined by uni- multivariate analytical methods. Receiver operating...
More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting IL-37 is involved atherosclerosis-related diseases. However, plasma levels patients with acute syndrome (ACS, including unstable angina pectoris myocardial infarction) have yet to be investigated.Plasma IL-37, IL-18, IL-18BP were measured 50 stable (SAP), 75 (UAP), 67 infarction (AMI), 65 control...
Lymphopenia is a useful predictive factor in several cancers. The aim of this study was to determine the prognostic value lymphopenia patients with esophageal squamous cell carcinoma (ESCC). A retrospective analysis 307 consecutive who had undergone esophagectomy for ESCC conducted. In our study, lymphocyte count (LC) fewer than 1.0 Giga/L defined as lymphopenia. Kaplan–Meier method used calculate cancer-specific survival (CSS). Cox regression analyses were performed evaluate factors....
BackgroundRecent evidence has demonstrated that interleukin 12p35 knockout (IL-12p35 KO) is involved in cardiac diseases by regulating the inflammatory response. The involvement of cells also been observed doxorubicin (DOX)-induced injury. This study aimed to investigate whether IL-12p35 KO affects DOX-induced injury and underlying mechanisms.MethodsFirst, effect DOX treatment on expression was assessed. In addition, injury, mice were treated with DOX. Because mutual subunit IL-12 IL-35,...
Background . Previous studies demonstrated that the subsets of CD4+ T helper (Th) cells are closely related to vascular diseases, including atherosclerosis and hypertension. This study is aimed at investigating circulating Th1, Th2, Th9, Th17, Th22, Treg levels in aortic dissection (AD) patients. Methods Blood samples from AD (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>56</mml:mn></mml:math>) non-AD (NAD, <mml:math...
Background Accumulating evidence shows that the novel anti-inflammatory cytokine IL-35 can efficiently suppress effector T cell activity and alter progression of inflammatory autoimmune diseases. The two subunits IL-35, EBI3 p35, are strongly expressed in human advanced plaque, suggesting a potential role atherosclerosis coronary artery disease (CAD). However, plasma levels patients with CAD have yet to be investigated. Methods Plasma IL-10, TGF-β1, IL-12 IL-27 were measured using an ELISA...
Recent studies have shown that the presence of systemic inflammation correlates with poor survival in various cancers. The aim this study was to determine prognostic values neutrophil lymphocyte ratio (NLR) and platelet (PLR) patients small cell carcinoma esophagus (SCCE). Preoperative NLR PLR were evaluated 43 SCCE from January 2001 December 2010. significance both markers then determined by uni‐ multivariate analytical methods. Receiver operating characteristic (ROC) curves also plotted...
Background: Recent studies have shown that the presence of systemic inflammation correlates with poor survival in various types cancers. This study investigated usefulness a novel inflammation-based prognostic system, using combination neutrophil lymphocyte ratio (NLR) and platelet (PLR), collectively named CNP, for predicting patients esophageal squamous cell carcinoma (ESCC). Materials methods: The CNP was calculated on basis data obtained day admission: both elevated NLR (>3.45) PLR...
The prognostic value of inflammation indexes in esophageal cancer has not been established. Recent studies have shown that the advanced lung index (ALI) is a useful predictive factor. purpose current study was to determine whether ALI for predicting long-term survival patients with squamous cell carcinoma (ESCC).A total 293 who had undergone esophagectomy ESCC were included. calculated as body mass × serum albumin/neutrophil-to-lymphocyte ratio. Then, divided into two groups: ≥18 and <18....
Objective One of the major obstacles to ovarian tissue preservation is delayed angiogenesis that leads follicles lost after transplantation. The aim present study was investigate effects bFGF and VEGF on heterotopic transplanted using a mouse model. Methods Female mice underwent bilateral ovariectomy. Ovarian tissues encapsulated by fibrin hydrogels were subcutaneously into recipient mice, in which hormonal cyclicity absent. fibrinogen solution mixed with bFGF, VEGF, or mixture VEGF. grafts...
The neutrophil-to-lymphocyte ratio (NLR) is a useful predictive factor in several cancers. However, the prognostic value of NLR patients with esophageal cancer (EC) still controversial. Therefore, it was necessary for us to perform meta-analysis evaluate EC.A systematic literature search performed by using Web Science, PubMed Central, and Medline EC. deadline our primary July 10, 2014. This conducted accordance PRISMA guidelines. Pooled hazard (HR) 95% confidence interval (CI) used assess...
OBJECTIVE: The prognostic value of inflammation indexes in esophageal cancer was not established. In this study, therefore, both values Glasgow score (GPS) and combination platelet count neutrophil lymphocyte ratio (COP-NLR) patients with squamous cell carcinoma (ESCC) were investigated compared. METHODS: This retrospective study included 375 who underwent esophagectomy for ESCC. cancer-specific survival (CSS) calculated by the Kaplan-Meier method, difference assessed log-rank test. GPS as...
The prognostic value of inflammatory index in esophageal cancer (EC) was not established. In the present study, we initially used a nomogram to predict red cell distribution width (RDW) patients with squamous carcinoma (ESCC).A total 277 ESCC were included this retrospective study. Kaplan-Meier method calculate cancer-specific survival (CSS). A established prognosis for CSS.The mean RDW 14.5 ± 2.3%. then divided into two groups: ≥ 14.5% and < 14.5%. Patients had significantly better 5-year...
Interleukin-11 (IL-11) is an important inflammatory cytokine and has been demonstrated to participate in cardiovascular diseases. However, there have no studies about the role of IL-11 heart failure (HF). The present study aimed at investigating whether levels are associated with cardiac prognosis patients HF.The plasma concentrations were measured 240 chronic HF (CHF) 80 control subjects without signs significant disease. In addition, we prospectively followed these CHF endpoints...
Interleukin- (IL-) 35, a novel functional cytokine of regulatory T cells (Treg) comprised the IL-12p35 subunit and other Epstein-Barr virus-induced gene 3 (EBI3), regulates activity CD4+ macrophages, thereby playing critical role in inflammatory autoimmune diseases. Previous studies demonstrated that both recombinant mice human IL-35 attenuated atherosclerosis ApoE-/- mice. Additionally, EBI3 deficiency enhanced activation macrophages increased atherosclerotic lesions LDLR-/- This study...
Uricase replacement therapy is a promising approach for managing hyperuricemia and gout but hindered by challenges such as short blood circulation time, reduced catalytic activity, excessive hydrogen peroxide (H2O2) production. These limitations necessitate innovative strategies to enhance therapeutic efficacy safety. We designed synthesized RBC@SeMSN@Uri, red cell-coated biomimetic self-cascade bioreactor, which encapsulates uricase (Uri) selenium-based nano-scavenger (SeMSN) within RBC...
Migraine has been linked to a heightened risk of cardiovascular disease, and acute treatment drugs, such as triptans, might increase this risk. This study aimed determine whether the elevated is primarily attributable underlying migraine condition or modalities utilized. Additionally, we investigated effects managing traditional factors influence healthy lifestyle scores on association. population-based investigation leveraged data from UK Biobank, encompassing participants recruited between...
Several researchers have determined the tumor length to be an important prognostic indictor of esophageal cancer (EC). However, controversy exists concerning optimal cut-off points for predict overall survival. The aim this study was determine value and propose optimum point in predicting survival difference elderly patients with squamous cell carcinoma (ESCC).From January 2001 December 2009, a retrospective analysis 132 consecutive older than 70 years ESCC conducted. A receiver-operating...
Abstract Background Lifestyle are closely related to migraine. However, there is a lack of studies investigating the association between Healthy lifestyle or Life’s Essential 8 (LE8) and risk The objective this research was investigate relationship scores essential scores, Methods 332,895 UK Biobank participants without migraine were included. assessed using seven factors, categorized as poor, intermediate, ideal. LE8, based on American Heart Association (AHA) Guidelines for Cardiovascular...