A5101443429- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Carcinogens and Genotoxicity Assessment
- Myasthenia Gravis and Thymoma
- Circular RNAs in diseases
- RNA Research and Splicing
- Air Quality and Health Impacts
- Ruminant Nutrition and Digestive Physiology
- Traditional Chinese Medicine Analysis
- Neurological Disease Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Renal and related cancers
- Reproductive Physiology in Livestock
- Cerebrovascular and Carotid Artery Diseases
- Heavy Metal Exposure and Toxicity
- Medicinal Plants and Bioactive Compounds
- Genetic and phenotypic traits in livestock
- RNA modifications and cancer
- Arsenic contamination and mitigation
- RNA regulation and disease
- Caveolin-1 and cellular processes
- Occupational exposure and asthma
- Spectroscopy and Chemometric Analyses
- Magnesium in Health and Disease
- Glutathione Transferases and Polymorphisms
Boys Town National Research Hospital
2023-2025
Boys Town
2023-2025
Nanjing Medical University
2024
Huaian First People’s Hospital
2024
University of Oklahoma Health Sciences Center
2020-2023
Nanjing University of Chinese Medicine
2019-2021
Xi'an Medical University
2020-2021
Weatherford College
2021
Yulin Orthopedics Hospital of Chinese and Western Medicine
2021
ShenZhen People’s Hospital
2021
Background/Aims: Recent studies have shown that circulating microRNAs (miRNAs) are emerging as promising biomarkers for cardiovascular diseases. This study aimed to determine whether miR-19b-3p, miR-134-5p and miR-186-5p can be used novel indicators acute myocardial infarction (AMI). Methods: To investigate the kinetic expression of three selected miRNAs, we enrolled 18 patients with AMI 20 matched controls. Plasma samples were collected from each participant, total RNA was extracted....
Prostaglandin F(2)(alpha) (PGF(2)(alpha)) released from the uterus causes alterations in luteal blood flow, reduces progesterone secretion, and induces luteolysis bovine corpus luteum (CL). We have recently discovered that flow periphery of mature CL acutely increases coincidently with pulsatile a metabolite PGF(2)(alpha) (PGFM). In this study, we characterized changes regional together endothelial nitric oxide synthase (eNOS) expression during spontaneous response to PGF(2)(alpha). Smooth...
DNA packaged into cancer cell-derived EV is not well appreciated. Here, we uncovered signatures of secreted by pancreatic cells. The cells and non-cancer counterparts exhibit distinct low vs. high molecular weight (LMW HMW) fragments distribution, respectively. Genome sequencing Single Nucleotide Variants analysis revealed that 95% reads 94% SNVs map to noncoding regions the genome. Given ~1% human genome represents coding regions, 5% mapping rate suggests a non-random enrichment certain...
Background: The thioredoxin system (TrxS) is crucial for maintaining redox balance by regulating cellular thiol levels and involved in various biological processes, including cancer progression. Thioredoxin reductase (TrxR), a key component of TrxS, reduces oxidized (Trx) using NADPH. This study investigates the inhibitory effects 2-bromo-2-nitro-1,3-propanediol (Bronopol, BP), preservative, on TrxR activity its impact thiols cell viability. Methods: Purified recombinant noncancer cells were...
Usher syndrome (USH) is a rare genetic disorder affecting vision, hearing, and balance. Identifying reliable biomarkers crucial for early diagnosis understanding disease mechanisms. MicroRNAs (miRNAs), key regulators of gene expression, hold promise as USH. This study aimed to identify minimal subset miRNAs that could serve effectively differentiate USH from controls. We employed ensemble feature selection techniques select the top appearing in at least three algorithms. Machine learning...
Plasma cell-free DNA (cfDNA) fragment size distribution provides important information required for diagnostic assay development. We have developed and optimized droplet digital PCR (ddPCR) assays that quantify short long fragments. These were used to analyze plasma cfDNA in human blood.Assays designed amplify 76,135, 490 905 base pair fragments of β-actin gene. analysis cell-free, exosome apoptotic body obtained from normal pregnant donors.The relative percentages 76, 135, bp non-pregnant...
Usher syndrome (USH) is an inherited disorder characterized by sensorineural hearing loss (SNHL), retinitis pigmentosa (RP)-related vision loss, and vestibular dysfunction. USH presents itself as three distinct clinical types, 1, 2, 3, with no biomarker for early detection. This study aimed to explore whether microRNA (miRNA) expression in cell lines dysregulated compared the miRNA pattern a line derived from healthy human subject. Lymphocytes patients individuals were isolated transformed...
Myasthenia gravis (MG) is an autoimmune disease, of which the pathogenesis has remained unclear. At present, MG does not have any effective treatment with minor side effects. Jian Ji Ning (JJN), a traditional Chinese medicine formula consisting 11 medicinal plants, been used in for many years. The present study aims to determine if herbal JJN could lighten clinical symptoms patients via regulation differential microRNAs (miRNAs) expression serum. should be orally administered twice day 6...
Background: Usher syndrome (USH) is a rare genetic disorder that affects both hearing and vision. It presents in three clinical types—USH1, USH2, USH3—with varying onset, severity, disease progression. Existing diagnostics primarily rely on profiling to identify variants USH genes; however, accurate detection before symptom onset remains challenge. MicroRNAs (miRNAs), which regulate gene expression, have been identified as potential biomarkers for disease. The aim of this study develop...
Objective: The objective of this study was to investigate the mechanisms underlying anti-embolism and extravasational effects traditional Chinese medical prescription YiqiHuoxue (YQHX) formula in ApoE-/-mice with cerebral vascular microemboli. Materials Methods: An model microemboli developed by infusing fluorescently labeled heterologous fibrin-rich microparticles into internal carotid artery ApoE-/-gene knockout male mice through common artery. Before injection, animals were randomly...
Abstract Numerous evidence has revealed that single-nucleotide polymorphisms (SNPs) are associated with liver cancer risk. To assess whether the MIR17HG risk in Chinese Han population, we performed a case–control (432 patients and 430 healthy controls) study. Genotyping of four variants was Agena MassARRAY platform. We used χ2 test to compare distribution SNPs allele genotypes frequencies cases controls. Odds ratios (ORs) 95% confidence intervals (CIs) were calculated by logistic regression...
Previous study has reported that Fuyuan Xingnao Decoction (FYXND) can be utilized for the treatment of patients with diabetes mellitus (DM) combined cerebral infarction (CI) effectively.We will search from following databases MEDLINE, EMBASE, Cochrane Library, PsycINFO, Global Health, Web Science, Allied and Complementary Medicine Database, Chinese Biomedical Literature China National Knowledge Infrastructure. All searched inception to present without language limitation. Two independent...
To study the use of Jianjining in treatment myasthenia gravis (MG) patients with a deficiency both spleen and kidney via theory on combination disease syndrome.Sixty MG were randomly divided into an group (n = 30) treated granules Western Medicine (prednisone or pyridostigmine bromide) control granules. The dosage three drugs was reduced over course treatment. After 3 6 months treatment, curative effect evaluated muscle weakness severity scale (MWSS).The MWSS score after declined...