A5024285608- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Mast cells and histamine
- Cell Adhesion Molecules Research
- Kruppel-like factors research
- Skin and Cellular Biology Research
- Palliative Care and End-of-Life Issues
- Caveolin-1 and cellular processes
- Child Abuse and Trauma
- Childhood Cancer Survivors' Quality of Life
- Nail Diseases and Treatments
- Glycosylation and Glycoproteins Research
- Immunodeficiency and Autoimmune Disorders
- Asthma and respiratory diseases
- Urticaria and Related Conditions
- Autoimmune Bullous Skin Diseases
- Pain Mechanisms and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Cellular Mechanics and Interactions
- Cannabis and Cannabinoid Research
- Chronic Lymphocytic Leukemia Research
- Health, Medicine and Society
- Homicide, Infanticide, and Child Abuse
- Extracellular vesicles in disease
- Drug-Induced Adverse Reactions
Inserm
2014-2024
Université Paris Cité
2006-2024
Hôpital Necker-Enfants Malades
2015-2024
Assistance Publique – Hôpitaux de Paris
2020-2024
Agence des Aires Marines Protégées
2024
Institut des Maladies Génétiques Imagine
2021-2024
Centre de Gestion Scientifique
2023
Centre National de la Recherche Scientifique
2023
Centre National des Soins Palliatifs et de la Fin de Vie
2023
Institut Necker Enfants Malades
2021-2022
Tetraspanins are integral membrane proteins involved in a variety of physiological and pathological processes. In cancer, clinical experimental studies have reported link between tetraspanin expression levels metastasis. play role as organizers multimolecular complexes the plasma membrane. Indeed each associates specifically with one or few other forming primary complexes. Thus, tetraspanin-tetraspanin associations lead to molecular network interactions, "tetraspanin web." We performed...
Olmsted syndrome is a genodermatosis characterized by painful and mutilating palmoplantar keratoderma (PPK) that progresses from infancy onward lacks an effective treatment. It most often caused mutations in the transient receptor potential vanilloid 3 (TRPV3) gene. In animal models keratinocyte cell lines, TRPV3 signaling leads to epidermal growth factor (EGFR) transactivation.To examine possibility of blocking EGFR transactivation with inhibitor erlotinib hydrochloride treat PPK patients...
BackgroundMastocytosis and monoclonal mast cell (MC) activation syndrome (MMAS) are heterogeneous conditions characterized by the accumulation of atypical MCs. Despite recurrent involvement KIT mutations, pathophysiologic origin mastocytosis MMAS is unclear. Although hereditary α-tryptasemia (HαT, related to TPSAB1 gene duplication) abnormally frequent in these diseases, it not known whether association coincidental or causal.ObjectiveWe evaluated prevalence HαT all subtypes assessed with...
Plasmodium sporozoites can enter host cells by two distinct pathways, either through disruption of the plasma membrane followed parasite transmigration cells, or formation a parasitophorous vacuole (PV) where further differentiates into replicative exo-erythrocytic form (EEF). We now provide evidence that following invasion without PV formation, transmigrating falciparum and yoelii partially develop EEFs inside hepatocarcinoma cell nuclei. also found rodent P. infect both mouse human...
Tetraspanins are integral membrane proteins involved in a variety of physiological and pathological processes. In cancer, clinical experimental studies have reported link between tetraspanin expression levels metastasis. play role as organizers molecular network interactions, the "tetraspanin web". Here, we performed proteomic characterization web using model human colon cancer consisting two cell lines derived from primary tumor metastasis same patient. The complexes were isolated after...
Tumor invasion and metastasis are major obstacles to clinical treatment that rely on cell migration. Here, we elucidate a mechanism of colon carcinoma migration is supported by the surface tetraspanin Co-029 (tspan8), which known favor tumor progression metastasis. This unmasked silencing E-cadherin or its associated adapter molecule p120-catenin (p120ctn), it involves switch in signaling between collagen-binding integrins α(1)β(1) α(2)β(1). Direct interaction was documented chemical...
Abstract Tspan8 exhibits a functional role in many cancer types including pancreatic, colorectal, oesophagus carcinoma, and melanoma. We present first study on the expression function of breast cancer. protein was majority human primary lesions metastases brain, bone, lung, liver. In syngeneic rat model, + tumours formed multiple liver spleen metastases, while − exhibited significantly diminished ability to metastasise, indicating metastases. Addressing underlying molecular mechanisms, we...
Abstract Inherited epidermolysis bullosa (EB) comprises rare disorders that manifest with fragility and blistering of the skin mucous membranes, variable clinical severity. Management EB is challenging due to disease rarity complexity, wide range extracutaneous manifestations a profound impact on daily life for patient family members. Although reference centres providing multidisciplinary care exist in each European country, it common healthcare professionals are not specialized this...
New therapeutic agents are needed in digestive tract tumors. Co-029/tspan8 is a tetraspanin frequently expressed on human colorectal tumors, In this work, we report the effects of monoclonal antibody Ts29.2, targeting Co-029/tspan8, tumor cells vitro and after implantation nude mice. HT29, Isreco1 SW480 cell lines were used for study. HT29 has strong endogenous expression whereas don't express only weak expression. transduced to at same level as HT29. order check specificity effect low...
Patients with metastatic castration-resistant prostate cancer (mCRPC) develop resistance to conventional therapies including docetaxel (DTX). Identifying molecular pathways underlying DTX is critical for developing novel combinatorial prevent or reverse this resistance. To identify transcriptomic signatures associated acquisition of chemoresistance we profiled gene expression in DTX-sensitive and -resistant mCRPC cells using RNA sequencing (RNA-seq). PC3 DU145 were selected phenotype was...
Galectins are a family of beta-galactoside binding molecules involved in cell--extracellular matrix adhesion processes. Specifically, Galectin-3 (Gal-3), one the members this plays role cell processes as well survival or apoptosis. Gal-3 was also hypothesized to represent useful tool tumor characterization, for example, thyroid tumors. We report herein results obtained by evaluating expression colon cells from human adenomas and adenocarcinomas with two different methodologies:...
Colorectal carcinoma cells Isreco1 display an ability to migrate controlled by a complex set of signals issued from the membrane. By comparing infected mycoplasmas and free cells, we have established that basal 2D migration is dependent on double signal mediated collagen receptors integrins alpha1/2 Toll-Like receptor TLR2. The can be replaced TLR2 ligand functional effect neutralized silencing MyD88. Following previous observation downregulation E-cadherin/p120 catenin increases cell...
Oral amitriptyline hydrochloride (amitriptyline) is ineffective against some forms of chronic pain and often associated with dose-limiting adverse events. We evaluated the potential effectiveness high-dose topical in a preliminary case series chemotherapy-induced peripheral neuropathy patients investigated whether local or systemic events use were present these patients. also mechanism action topically administered mice. Our suggested that 10% treatment was relief patients, without side...
Pachyonychia congenita (PC) is a genodermatosis associated with severe painful palmoplantar keratoderma (PPK) and thickened dystrophic nails caused by autosomal dominant-negative mutations in five genes encoding keratins 6A-B-C, 16, 17. The mechanical, surgical, or medical options for PC are inefficient. Given ErbB/Her family members' role epidermal homeostasis, this study sought to investigate the possibility of treating patients PPK blocking signaling either EGFR (Her1) inhibitor erlotinib...
Mastocytosis patients often experience a number of symptoms, including mastocytosis-associated pain that is difficult to manage due resistance usual antalgic treatments and/or the patient's poor tolerance. display significantly higher levels indoleamine-2,3-dioxygenase-1 (IDO1) activity, leading hyperactivation N-methyl-D-aspartate receptor. As cannabidiol (CBD) known inhibit IDO1's enzymatic we hypothesized pharmaceutical-grade CBD an effective treatment for pain. Patients with non-advanced...
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Systemic mastocytosis (SM) corresponds to a rare and heterogeneous spectrum of diseases characterized by the accumulation atypical mast cells (MCs). Advanced (Adv-SM) is associated with poor survival; in contrast, patients non-advanced SM (non-Adv-SM) usually have normal life expectancy but may experience quality life. Despite recent therapeutic progress including tyrosine kinase inhibitors, new treatment options are needed for refractory and/or intolerant both severely symptomatic Adv-SM....