A5023261473- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- MicroRNA in disease regulation
- interferon and immune responses
- GDF15 and Related Biomarkers
- Drug Transport and Resistance Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Protist diversity and phylogeny
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug-Induced Hepatotoxicity and Protection
- Nitric Oxide and Endothelin Effects
- Cancer, Lipids, and Metabolism
- ATP Synthase and ATPases Research
- Liver Disease and Transplantation
- Adenosine and Purinergic Signaling
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
State Key Laboratory of Oncogene and Related Genes
2019-2023
Renji Hospital
2019-2023
Shanghai Jiao Tong University
2017-2023
Johns Hopkins Medicine
2023
Johns Hopkins University
2023
Shanghai Cancer Institute
2019-2022
Shanghai University of Traditional Chinese Medicine
2015-2022
Shanghai University
2013-2015
East China University of Science and Technology
2012-2013
State Key Laboratory of Bioreactor Engineering
2013
Abstract Circular RNAs (circRNA) are a class of covalently closed single-stranded that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated non-small cell lung (NSCLC) tissues, and negatively correlate with NSCLC malignant features. Elevated inhibits growth metastasis cells. Mechanistically, functions as scaffold enhance the interaction between TRIM25 IGF2BPs, positive regulator tumor progression metastasis. This TRIM25/circNDUFB2/IGF2BPs ternary...
Abstract Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role circRNA lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore expression profiles and mRNA 5 paired samples LUSC. By analyzing co-expression network differentially expressed circRNAs dysregulated mRNAs, identify that cycle-related circRNA, circTP63 , is upregulated LUSC tissues its upregulation correlated with larger tumor size higher TNM stage patients....
Peroxisome proliferator-activated receptor-gamma (PPARγ) coactivator-1α (PGC1α) is a key regulator of mitochondrial biogenesis and respiration. PGC1α involved in the carcinogenesis, progression, metabolic state cancer. However, its role progression hepatocellular carcinoma (HCC) remains unclear.In this study, we observed that was down-regulated human HCC. A clinical study showed low levels expression were correlated with poor survival, vascular invasion, larger tumor size. inhibited...
Background/Aims: Circulating long non coding RNAs (lncRNAs) have emerged recently as major players in tumor biology and may be used for cancer diagnosis, prognosis, potential therapeutic targets. We explored circulating lncRNA a predictor the tumorigenesis of non-small-cell lung (NSCLC). Methods: In this study, we applied microarray to screen biomarker NSCLC, utilizing RT-PCR (ABI 7900HT). A multi-stage validation risk score formula detection analysis was used. Results: discovered that three...
Resveratrol, a natural polyphenolic compound found in foods and beverages, has attracted increasing attention recent years because of its potent chemopreventive anti-tumor effects. In this study, the effects resveratrol on expression P-glycoprotein/multi-drug resistance protein 1 (P-gp/MDR1), underlying molecular mechanisms, were investigated oxaliplatin (L-OHP)-resistant colorectal cancer cells (HCT116/L-OHP). Resveratrol downregulated MDR1 mRNA levels reduced promoter activity. It also...
Abstract Background Biological role and clinical significance of circular RNAs (circRNAs) remain largely unknown. Herein, we aimed to investigate biological function, molecular mechanism, a RNA FOXM1 (circFOXM1) in non-small cell lung cancer (NSCLC). Methods Expression circFOXM1 was measured 48 paired samples NSCLC by qRT-PCR. Functional roles on tumor cells were explored vitro vivo assays. Transcriptome sequencing employed screen the molecules involved regulatory network....
Emerging evidence has indicated that deregulation of long non‐coding RNA s (lnc s) can contribute to the progression and metastasis human cancer, including hepatocellular carcinoma ( HCC ). However, roles most lnc in remain largely unknown. Here we found a noncoding termed Sch LAH (seven chromosome locus associated with ; also called BC 035072) was generally downregulated . Low expression significantly correlated shorter overall survival patients. In vitro vivo assays overexpression...
Alterations in cellular metabolism are one of the characteristics cancer. They not only result tumor progression but also cause cancer initiation. Pyruvate dehydrogenase kinase 4 (PDK4) is a key metabolic enzyme, which regulates cell by inhibiting pyruvate (PDH). However, function and regulating mechanism PDK4 HCC remain unclear. Here, we found that expression was significantly decreased tissues, its downregulation could predict poor prognosis patients. Silencing facilitated proliferation...
Abstract Background Numerous studies have used multi-region sampling approaches to characterize intra-tumor heterogeneity (ITH) in hepatocellular carcinoma (HCC). However, conventional strategies do not preserve the spatial details of samples, and thus, potential influences distribution on patient-wise ITH (represents overall level tumor a given patient) long been overlooked. Furthermore, gene-wise transcriptional expression pattern genes across different regions) HCC is also under-explored,...
Exploiting key regulators responsible for hepatocarcinogenesis is of great importance the prevention and treatment hepatocellular carcinoma (HCC). However, players contributing to remain poorly understood. We explored molecular mechanisms underlying carcinogenesis progression HCC development potential new therapeutic targets.The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) Genotype-Tissue Expression (GTEx) databases were used identify genes with enhanced expression in liver...
Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma (HCC). The molecular mechanism underlying HCC metastasis remains unclear. In this study, we found that argininosuccinate synthase 1 (ASS1) expression was significantly decreased down-regulation ASS1 closely correlated with prognosis in patients. DNA methylation led to HCC. Stable silencing promoted migration invasion cells, whereas overexpression ASS1-inhibited cells vivo vitro. We also revealed...
It is well established that macrophage infiltration involved in concanavalin A (conA)-induced liver injury. However, the role of macrophages conA-induced renal injury remains unknown. The aims this study were to investigate and determine whether paeoniflorin (PF) could inhibit into kidney. BALB/C mice pre-treated with or without PF 2 h (h) before conA injection. At 8 after con injection, all sacrificed; kidney histology studied. CD68 expression was detected by immunohistochemical real-time...
Hepatic stellate cell (HSC) activation is activated mainly by endotoxin and transforming growth factor (TGF-β1) in chronic liver injury, consequently, can be important therapeutic targets. Xia-yu-xue decoction (XYXD), a classical recipe used China to treat fibrosis, has been revealed inhibit hepatic fibrosis animal models, the mechanism of action XYXD remains elusive. In present study, we evaluated whether reduced pro-fibrogenic pathways induced lipopolysaccharide (LPS) TGF-β1 HSCs.The vivo...
Abstract Extra copies of centrosomes are frequently observed in cancer cells. To survive and proliferate, cells have developed strategies to cluster extra-centrosomes form bipolar mitotic spindles. The aim this study was investigate whether centrosome clustering (CC) inhibition (CCi) would preferentially radiosensitize non–small cell lung (NSCLC). Griseofulvin (GF; FDA-approved treatment) inhibits CC, combined with radiation treatment (RT), resulted a significant increase the number NSCLC...
Photodynamic therapy (PDT) is a regulatory-approved modality for treating variety of malignant tumors. It induces tumor tissue damage via photosensitizer-mediated oxidative cytotoxicity. The heat shock protein 70 (HSP70-1) stress encoded by the HSPA1A gene and significantly induced associated with PDT. aim this study was to identify functional region promoter that responds PDT-induced uses responsiveness expression establish rapid cost-effective photocytotoxic assessment bioassay evaluate...
Abstract Cyclosporin A (CsA) is a widely used immunosuppressive agent that also causes hypertension. However, the molecular basis for CsA‐induced hypertension remains elusive. In this study, we established an in vitro model pathological changes vasculature. Rat mesenteric arteries were incubated with CsA 24 hr organ culture system. Both vasocontraction and vasorelaxation artery studied using myograph technology, mRNA expressions of contractile receptors determined by real‐time PCR. The...
Renal pathological changes in cirrhotic rat have not been extensively reported. The aim of this study was to investigate whether Xiayuxue decoction (XYXD) could attenuate renal injury induced by bile duct ligation (BDL), with special focus on the mechanisms promoting macrophage apoptosis. rats were treated BDL for 5 weeks and administered 0.36 g/kg XYXD intragastrically from day 1 initiating BDL. tissue monitored hematoxylin-eosin Sirius red staining. Macrophage infiltration proinflammatory...
Previous studies have reported that 8-c [6-(2-(2-(dimethylamino)ethylamino)ethylamino)-2-octyl-1H-benzo[de]isoquinoline-1,3(2H)-dione], a novel amonafide analogue, was generated as new anticancer candidate. However, little is known about its activity in chemoresistant cells. In this study, the antitumor effects of on multi-drug-resistant human colorectal carcinoma cancer cell lines HCT-116/L-OHP and HCT-8/VCR been investigated for first time. showed similar concentration-dependent inhibitory...
<p>Supplementary Materials & Methods</p>