A5101689428- Cell death mechanisms and regulation
- Mechanisms of cancer metastasis
- Melanoma and MAPK Pathways
- Insect Resistance and Genetics
- Graphene and Nanomaterials Applications
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer Mechanisms and Therapy
- Prostate Cancer Treatment and Research
- Insect and Pesticide Research
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Entomopathogenic Microorganisms in Pest Control
- Cancer Research and Treatments
- Ubiquitin and proteasome pathways
- Lung Cancer Research Studies
- Microtubule and mitosis dynamics
- Radiopharmaceutical Chemistry and Applications
- Epigenetics and DNA Methylation
- interferon and immune responses
- Anaerobic Digestion and Biogas Production
- Prostate Cancer Diagnosis and Treatment
- Protist diversity and phylogeny
- Pancreatic and Hepatic Oncology Research
- Microbial metabolism and enzyme function
University of Maryland, Baltimore
2022-2025
McMaster University
2024
University of Baltimore
2024
Johns Hopkins University
2023
Johns Hopkins Medicine
2023
Cleveland Clinic
2016-2023
NYU Langone Health
2023
University Hospitals of North Midlands NHS Trust
2018
National Institute for Parasitic Diseases
2006
Seoul National University
2001-2004
In metastatic castration-sensitive prostate cancer (mCSPC), disease volume plays an integral role in guiding treatment recommendations, including selection of docetaxel therapy, metastasis-directed and radiation to the prostate. Although there are multiple definitions volume, they have commonly been studied context metastases detected via conventional imaging (CIM). One such numeric definition termed oligometastasis, is heavily dependent on sensitivity modality. We performed international...
•Synchronous metastatic CSPC is associated with lower AR activity than metachronous disease.•Patients synchronous derive a greater benefit to combination plus non AR-based therapy.•Clinical and biologic differences between metastasis are most prominent in low-volume disease. BackgroundMetastatic castration-sensitive prostate cancer (mCSPC) commonly classified into high- subgroups which have demonstrated differential biology, prognosis, response therapy. Timing of has similarly clinical...
Abstract Purpose: Small cell lung cancer (SCLC) is a highly aggressive and deadly malignancy. Two major factors contributing to the high mortality of SCLC are early metastasis rapid development therapy resistance. Recent research suggests upregulation epithelial-mesenchymal transition (EMT) program EMT transcription factor Twist1 correlated with accelerated tumor progression chemoradiation (CRT) resistance in SCLC. However, causal relationship between these aspects biology has not been...
Abstract Most patients with lung squamous cell carcinoma (LSCC) undergo chemotherapy, radiotherapy, and adjuvant immunotherapy for locally advanced disease. The efficacy of these treatments is still limited because dose-limiting toxicity or locoregional recurrence. New combination approaches targets such as actionable oncogenic drivers are needed to advance treatment options LSCC. Moreover, other chemotherapy-ineligible limited. As such, there a critical need the development selective potent...
Current baculovirus expression systems typically produce soluble proteins that accumulate within the infected insect cell or are secreted into growth medium. A system has now been developed for incorporation of foreign proteins, along with matrix protein, polyhedrin, occlusion bodies. Initial studies showed a recombinant virus expressing translational fusion between polyhedrin and GFP did not form However, coexpressing native polyhedrin-GFP protein formed bodies fluoresced under UV light,...
Abstract Extra copies of centrosomes are frequently observed in cancer cells. To survive and proliferate, cells have developed strategies to cluster extra-centrosomes form bipolar mitotic spindles. The aim this study was investigate whether centrosome clustering (CC) inhibition (CCi) would preferentially radiosensitize non–small cell lung (NSCLC). Griseofulvin (GF; FDA-approved treatment) inhibits CC, combined with radiation treatment (RT), resulted a significant increase the number NSCLC...
It is known that CD95 (APO-1/Fas) expressed on the cell surface, and apoptotic death can be induced by ligation in cultured, proliferating human retinal pigment epithelial (RPE) cells. However, little about non-proliferating RPE In this study, cells were cultured up to 4 weeks after they reached confluence, simulate situ. There was no significant difference expression surface between predominantly proliferating, preconfluent non-proliferating, postconfluent flow cytometric assays. unlike...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer characterized by very poor survival outcomes. Genomic sequencing of human PDAC tissues and cell lines have identified four molecular subtypes: quasimesenchymal (QM), pancreatic progenitor, immunogenic, aberrantly differentiated endocrine exocrine (ADEX). QM-PDAC has the worse prognosis, but no in vivo models exist for this subtype. Our preliminary analysis using publicly available data demonstrated that...
Abstract In this study, we investigated the contributions of epithelial-mesenchymal transition (EMT) program to small cell lung cancer (SCLC) tumorigenesis and chemoradiation (CRT) response. SCLC is a highly aggressive deadly neuroendocrine malignancy. Two major factors that contribute high mortality are (1) early metastasis (2) rapid development therapy resistance. Recent research suggests upregulation EMT transcription factor Twist1 correlated with accelerated tumor progression CRT...
Abstract Lung squamous cell carcinoma (LSCC) is the second most prevalent type of lung cancer with no FDA-approved targeted therapies. Platinum-based chemotherapy and immunotherapy remain cornerstone current treatments for advanced LSCC, 5-year survival rate less than 10%. Despite abundant knowledge mutational landscape there a paucity effective Amplification chromosome 3q26 common genomic alteration in LSCC this leads to overexpression oncogenic kinases like TNIK. TNIK amplification occurs...
Abstract Chemoradiation (CRT) is the standard first-line therapy for limited stage small cell lung cancer (LS-SCLC), which characterized by early metastasis, intrinsic-acquired CRT resistance and tumor recurrence. confers a 20-25% 5-year overall survival in patients with LS-SCLC. In this study, we utilized patient-derived xenograft (PDX) models to demonstrate of SCLC identified candidate genes from various PDX that represent majority molecular subtypes (n=4 include SCLC-A SCLC-N subtypes)....
Abstract Non-small cell lung carcinoma (NSCLC) is a major cause of cancer mortality. High expression the epithelial-to-mesenchymal transition transcription factor TWIST1 strongly associated with metastatic cancers and treatment resistance. Additionally, can upregulate O-GlcNAcylation which (1) required to suppress fail-safe programs such as oncogene (KRasG12D)-induced senescence (OIS) accelerate tumorigenesis in primary NSCLC tumors, (2) potential modulator DNA repair/radiation response. To...
<p>Combinations of NCB-0846 with conventional chemotherapeutic agents were either antagonistic or additive.</p>