A5105979669- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver physiology and pathology
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis B Virus Studies
- Pharmacological Effects of Natural Compounds
- Pediatric Hepatobiliary Diseases and Treatments
- Lung Cancer Diagnosis and Treatment
- Animal Virus Infections Studies
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Studies
- Flavonoids in Medical Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Drug Transport and Resistance Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Heart Failure Treatment and Management
- Endoplasmic Reticulum Stress and Disease
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Galectins and Cancer Biology
- Ginseng Biological Effects and Applications
- Botanical Studies and Applications
- Pneumonia and Respiratory Infections
University of Macau
2025
Shanghai University of Traditional Chinese Medicine
2012-2023
Central Hospital of Putuo District
2012-2022
Shanghai University
2013
Shuguang Hospital
2010
Objective Although glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-β superfamily, its function in liver fibrosis has rarely been studied. Here, we investigated role GDNF hepatic stellate (HSC) activation and humans mice. Design expression was examined biopsies sera from patients with fibrosis. The functional mice adenoviral delivery gene, sgRNA CRISPR/Cas9 administration GDNF-blocking antibodies. on HSC using human mouse primary HSCs. binding...
Aims: Sorafenib, which has been used extensively for the treatment of renal cell cancer and advanced hepatocellular carcinoma (HCC), also shown to have antifibrotic effects in liver fibrosis. However, sorafenib on fibrosis are unknown. Therefore, we investigated whether inhibited a mouse model unilateral ureteral obstruction (UUO) further explored potential mechanism. Methods: Mice underwent UUO followed by vehicle or treatment. The expression CD68, macrophage marker, pro-inflammatory...
Evidence for using bicyclol in drug-induced liver injury (DILI) is limited. This study aimed to explore the efficacy and safety of acute DILI.This was a multicenter, randomized, double-blinded, double-dummy, active-controlled, superiority phase II trial. Patients with idiosyncratic DILI were randomized 1: 1:1 low-dose (25 mg times day [TID]), high-dose (50 TID) polyene phosphatidylcholine (control) groups. The primary endpoint decrease from baseline serum alanine aminotransferase (ALT)...
Aim . To evaluate and predict the therapeutic efficacy of Fuzheng-Huayu tablet (FZHY) based traditional Chinese Medicine (TCM) syndrome differentiation or TCM symptoms on chronic hepatitis B caused cirrhosis (HBC). Methods. The trial was designed according to CONSORT statement. It a multi-center, double-blind, randomized, placebo-controlled trail. Several clinical parameters, Child-Pugh classification were detected evaluated. FZHY predicted by an established Bayes forecasting method...
Abstract Background Self-medication with antibiotics (SMA) is increasingly occurring worldwide, yet it a process that can lead to inappropriate use of antibiotics, potentially multiple adverse consequences such as an increased risk antibiotic resistance. Objective The objective this study assess the prevalence self-medication among Chinese population and investigate factors associated behavior. Methods A multi-stage sampling method was employed carry out national cross-sectional...
It is well established that macrophage infiltration involved in concanavalin A (conA)-induced liver injury. However, the role of macrophages conA-induced renal injury remains unknown. The aims this study were to investigate and determine whether paeoniflorin (PF) could inhibit into kidney. BALB/C mice pre-treated with or without PF 2 h (h) before conA injection. At 8 after con injection, all sacrificed; kidney histology studied. CD68 expression was detected by immunohistochemical real-time...
Hepatic stellate cell (HSC) activation is activated mainly by endotoxin and transforming growth factor (TGF-β1) in chronic liver injury, consequently, can be important therapeutic targets. Xia-yu-xue decoction (XYXD), a classical recipe used China to treat fibrosis, has been revealed inhibit hepatic fibrosis animal models, the mechanism of action XYXD remains elusive. In present study, we evaluated whether reduced pro-fibrogenic pathways induced lipopolysaccharide (LPS) TGF-β1 HSCs.The vivo...
The neutrophil-to-lymphocyte ratio (NLR) has been reported as a prognostic marker of hepatocellular carcinoma (HCC); however, the relationship between NLR and risk HCC occurrence yet to be systematically elucidated. We aimed investigate association in patients with hepatitis B-caused cirrhosis (HBC) undergoing antiviral therapy.A total 1599 HBC receiving entecavir or tenofovir at three tertiary hospitals June 2014 November 2017 were included. Cox proportional hazards regression was used...
To elucidate the role of Fuzheng Huayu Capsule, a herbal formula, in prevention esophageal variceal bleeding cirrhotic patients, multicenter randomized and placebo-controlled trial was carried out. One hundred forty-six patients with varices were enrolled to compare probability upper gastrointestinal survival between Capsule group controlled for duration 2 years. The results demonstrated that FZHYC could effectively reduce risk improve rates varices, especially combination capsule...
Traditional Chinese medicine (TCM) syndrome is an important basis for TCM diagnosis and treatment. As Child-Pugh classification as well compensation decompensation phase in liver cirrhosis, it also underlying clinical classification. In this paper, we investigated the correlation between single nucleotide polymorphisms (SNPs) of Interleukin-10 (IL-10) syndromes patients with hepatitis B cirrhosis (HBC). Samples were obtained from 343 HBC China. Three SNPs IL-10 (−592A/C, −819C/T, −1082A/G)...
Prognostic significance of family with sequence similarity 83, member D (FAM83D) in hepatocellular carcinoma (HCC) patients has not been well-investigated using Gene Expression Omnibus (GEO) series and TCGA database, we compared FAM83D expression levels between tumor adjacent tissues, correlated tumors outcomes clinico-pathological features HCC patients. Validated GSE33006, GSE45436, GSE84402 TCGA, was significantly overexpressed tissues than that (all P<0.01). up-regulation associated worse...
Intestine-derived endotoxin is thought to play a role in the development of liver fibrosis. However, pathological change intestine during fibrosis still poorly understood. Here, we investigated effects Xia-yu-xue decoction (XYXD) on intestinal inflammation, apoptosis, and tight junction integrity carbon tetrachloride (CCl4)-induced fibrosis.Murine was developed by CCI4 treatment three times per week over 6-week period. The CCl4-treated mice were divided into two groups: CCl4-water group...
Aims The biochemical response after ursodeoxycholic acid (UDCA) treatment contributes toward predicting the prognosis for primary biliary cholangitis (PBC) patients. This study aimed to establish a score model that can be used response. Patients and methods A total of 218 patients in derivation group 66 verification were enrolled. Response endpoints based on Barcelona criteria combined with Paris I criteria. We determined independent factors by univariate multivariate analyses. Then, we...
To evaluate the efficacy of Fuzhenghuayu capsule for prevention oesophageal variceal bleeding in patients with liver cirrhosis.A multicentre randomized placebo-controlled trial was conducted. A total 181 cirrhosis were enrolled study and randomly assigned to different groups according level bleeding. Patients light varices received or a placebo. medium heavy either alone, plus propranolol, propranolol history For all patients, treatment lasted 2 years. The primary end point secondary points...
Objectives: The purpose of this study was to compare macrovascular invasion (MVI)-free survival (MFS) at the three-year follow-up in patients with hepatocellular carcinoma (HCC) who underwent hepatic resection (HR), transcatheter arterial chemoembolization (TACE), or TACE combined radiofrequency ablation (TACE-RFA). Materials and Methods: We retrospectively analyzed medical records 828 were diagnosed Barcelona Clinic Liver Cancer (BCLC) stage A B HCC. Of these patients, 116 HR, 395 TACE-RFA,...
Aim. To investigate the correlation of Fuzheng-Huayu tablet (FZHY) efficacy on chronic hepatitis B caused cirrhosis (HBC) and single nucleotide polymorphisms (SNPs) CYP1A2. Methods. After 111 cases HBC with 69 excess, 21 deficiency-excess, deficiency ZHENGs (ZHENG, also called traditional Chinese medicine syndrome) were treated by FZHY for 6 months, clinical symptoms, Child-Pugh score, ZHENG score observed. Three SNPs in CYP1A2 gene detected analyzed using SNaPshot assay. Results. In between...
Renal pathological changes in cirrhotic rat have not been extensively reported. The aim of this study was to investigate whether Xiayuxue decoction (XYXD) could attenuate renal injury induced by bile duct ligation (BDL), with special focus on the mechanisms promoting macrophage apoptosis. rats were treated BDL for 5 weeks and administered 0.36 g/kg XYXD intragastrically from day 1 initiating BDL. tissue monitored hematoxylin-eosin Sirius red staining. Macrophage infiltration proinflammatory...
The aim was to evaluate the efficacy and safety of Yanggan Jian (YGJ) in HBV-infected patients with decompensated cirrhosis.This randomized, double-blind controlled trial enrolled 160 HBV-related cirrhosis who were already receiving or about start antiviral therapy. Patients randomly assigned receive YGJ placebo for 24 weeks, followed-up 36 weeks. primary outcome proportion a ≥2 point reduction Child-Turcotte-Pugh (CTP) score from baseline at week 24. Secondary outcomes CTP class score,...
We assessed the potential of glial cell line-derived neurotrophic factor (GDNF) as a useful biomarker to predict cirrhosis in chronic hepatitis B (CHB) patients.A total 735 patients from two medical centers (385 CHB and 350 healthy controls) were included determine association serum tissue GDNF levels with biopsy-proven cirrhosis. The diagnostic accuracy (sGDNF) was estimated compared other indices cirrhosis.We showed significantly higher sGDNF fibrosis (28.4 pg/ml vs. 11.6 without) (33.8...