A5101932980- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Dermatology and Skin Diseases
- Spondyloarthritis Studies and Treatments
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Alzheimer's disease research and treatments
- Cancer Cells and Metastasis
- Nutritional Studies and Diet
- Pleural and Pulmonary Diseases
- Psoriasis: Treatment and Pathogenesis
- Drug-Induced Hepatotoxicity and Protection
- Systemic Lupus Erythematosus Research
- Advanced Battery Technologies Research
- Asthma and respiratory diseases
- Genetic Syndromes and Imprinting
- High Altitude and Hypoxia
- Organ Transplantation Techniques and Outcomes
- Ion Transport and Channel Regulation
- Cancer Genomics and Diagnostics
- Biofuel production and bioconversion
- Gout, Hyperuricemia, Uric Acid
- Diet, Metabolism, and Disease
- Medical Imaging and Pathology Studies
- Inflammasome and immune disorders
Qilu University of Technology
2024
Chongqing University
2024
Shandong Academy of Sciences
2024
Fudan University
2011-2023
Huashan Hospital
2011-2023
Second Military Medical University
2016-2021
Changhai Hospital
2016-2021
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Institute of Hematology & Blood Diseases Hospital
2019
Dalian Medical University
2018
Abstract Background This phase 3 trial is the first to evaluate efficacy and safety of treatment with systemic TNF ‐α inhibitor, adalimumab, for Chinese patients moderate‐to‐severe plaque psoriasis. Methods In 12‐week, double‐blind, placebo‐controlled Period A, were randomized 4 : 1 receive adalimumab 40 mg every‐other‐week (following a single 80 dose), or placebo every‐other‐week. subsequent open‐label, B, all received starting at week 13, following single, blinded dose 12 matching (for...
Hyperuricemia is an important risk factor for vascular inflammation, yet the potential mechanisms of uric acid (UA) in endothelial cells are not well understood. UA has been found to stimulate renin-angiotensin system (RAS) activation human umbilical vein (HUVECs). (Pro)renin receptor ((P)RR) widely expressed and able induce RAS activation. Whether UA-induced cell inflammation via up-regulating (P)RR remained unknown. Primary HUVECs were cultured treated with UA, under condition or AT1...
Background Dupilumab is an antibody against interleukin-4 receptor α, used in the treatment of atopic dermatitis (AD). Objectives To evaluate efficacy and safety dupilumab adult Chinese patients with moderate-to-severe AD. Methods In this randomized, double-blind, placebo-controlled, parallel-group, phase III study, conducted between December 2018 February 2020, AD received (300 mg) or placebo once every 2 weeks for 16 weeks, were followed up 12 weeks. The primary endpoint was proportion...
Abstract Background A moderate intake of unsaturated fatty acids (UFA) is associated positively with improved insulin resistance. The aim this study was to investigate the relationship between dietary acids/total fats (UFA/TF) and Methods 15,560 participants were selected from National Health Nutrition Examination Survey (NHANES) database enrolled March 2017 2020, excluded those under 20 years age, pregnant, or missing data for key research items. Finally, 7,630 included in study. R software...
Background: With the wide application of lung cancer screening, detection rate multiple pulmonary nodules (MPNs) has increased annually. However, optimal therapeutic strategy for MPNs not achieved a consensus. This study aims to report novel hybrid technique treatment MPNs. Methods: A total 8 patients received CT-guided microwave ablation combined with video-assisted thoracic surgery from March 2020 2023. Three-dimensional reconstruction was conducted distinguish precise localization,...
To elucidate the role of Fuzheng Huayu Capsule, a herbal formula, in prevention esophageal variceal bleeding cirrhotic patients, multicenter randomized and placebo-controlled trial was carried out. One hundred forty-six patients with varices were enrolled to compare probability upper gastrointestinal survival between Capsule group controlled for duration 2 years. The results demonstrated that FZHYC could effectively reduce risk improve rates varices, especially combination capsule...
To evaluate the efficacy of Fuzhenghuayu capsule for prevention oesophageal variceal bleeding in patients with liver cirrhosis.A multicentre randomized placebo-controlled trial was conducted. A total 181 cirrhosis were enrolled study and randomly assigned to different groups according level bleeding. Patients light varices received or a placebo. medium heavy either alone, plus propranolol, propranolol history For all patients, treatment lasted 2 years. The primary end point secondary points...
Abstract Ferulic acid (FA) and p -coumaric ( -CA) are hydroxycinnamic inhibitors that mainly produced during the pretreatment of lignocellulose. To date, inhibitory mechanism compounds on Saccharomyces cerevisiae has not been fully elucidated. In this study, liquid chromatography-mass spectrometry (LC–MS) scanning electron microscopy (SEM) were used to investigate changes in S. cells treated with FA -CA. experiment, control group was denoted as CK, FA-treated F, -CA-treated P. One hundred...
BACKGROUND The frequent suboptimal efficacy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) to culture pancreatic cancer (PC) organoids (PCOs) poses a major challenge in the advancement personalized medicine for advanced PC. AIM To explore how obtain appropriate puncture tissues from EUS-FNB and optimize strategy efficiently constructing PCOs, providing an efficient tool medicine. METHODS Patients who underwent diagnosis PC tissue were prospectively enrolled. We refined...
The clinical, biochemical and mutation spectra of Chinese patients with Type III Bartter syndrome (type BS), a rare autosomal recessive disorder, were investigated. A total five unrelated aged 8 months to 24 years diagnosed type BS via analysis markers, including chloride, potassium calcium, genetic sequencing. levels insulin‑like growth factor‑1 (IGF‑1) evaluated ELISA study cultured amniocytes was conducted for prenatal diagnosis. child admitted polydipsia, polyuria, myasthenia...
<h3>Background</h3> For ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA) patients, tumor necrosis factor (TNF) inhibitors are recommended when disease activity persists despite non-steroidal anti-inflammatory drugs. <h3>Objectives</h3> To evaluate the efficacy safety of TNF in patients with AS nr-axSpA. <h3>Methods</h3> Searching PubMed, Embase, Cochrane Library, CNKI WanFang databases, we included all double-blind randomized controlled trials (RCTs) that...
Objective To establish a mouse model of chronic intermittent hypoxia (IH) and observe the changes expressions TRX, HIF-1 TNF-α in thoracic aorta after intervention hTRX.Methods 24 adult kunming mice were grouped 3:control group, IH group hTRX+IH group.Long-term test (totally 12 weeks) was proceeded homemade cabin. After finished, boracic taken detected by Western blot analysis immunohistochemistry. The results compared among 3 groups. Results expression levels significantly higher than those...
Alzheimer's Disease (AD) is a neurodegenerative disease that has an insidious onset and slow progression. Despite the vast amount of work done on AD, its pathogenesis still unclear, resulting in lack specific treatments. This deficit currently large focus for both Traditional Chinese Medicine (TCM) as well Western medical research. Although clear mechanism AD missing, current “Aβ cascade” theory core component thinking regarding . One school thought holds β-amyloid (Aβ) aggregation key...