A5040364540- Biochemical effects in animals
- Enzyme Structure and Function
- Cancer Research and Treatments
- Cytomegalovirus and herpesvirus research
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Herbal Medicine Research Studies
- Viral Infections and Immunology Research
- Calcium signaling and nucleotide metabolism
- Liver Disease and Transplantation
- Bioactive natural compounds
- Immune cells in cancer
- Optical Coatings and Gratings
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Insect-Plant Interactions and Control
- Photonic and Optical Devices
- Immunotherapy and Immune Responses
- S100 Proteins and Annexins
- Pediatric health and respiratory diseases
- Liver physiology and pathology
- Glioma Diagnosis and Treatment
- CAR-T cell therapy research
- Fungal Plant Pathogen Control
- RNA Interference and Gene Delivery
The University of Queensland
2017-2024
QIMR Berghofer Medical Research Institute
2022-2024
NAD depletion as pathogen response One way that plants respond to infection is by sacrificing the infected cells. The nucleotide-binding leucine-rich repeat immune receptors responsible for this hypersensitive carry Toll/interleukin-1 receptor (TIR) domains. In two papers, Horsefield et al. and Wan report these TIR domains cleave metabolic cofactor nicotinamide adenine dinucleotide (NAD + ) part of their cell-death signaling in pathogens. Similar links mammalian TIR-containing proteins...
Adoptive T-cell therapy targeting antigens expressed in glioblastoma has emerged as a potential therapeutic strategy to prevent or delay recurrence and prolong overall survival this aggressive disease setting. Ephrin receptor A3 (EphA3), which is highly glioblastoma; particular, on the tumor vasculature brain cancer stem cells, an ideal target for immune-based therapies.
There is now convincing evidence that the successful development of an effective CMV vaccine will require improved formulation and adjuvant selection capable inducing both humoral cellular immune responses. Here, we have designed a novel bivalent subunit based on CMV-encoded oligomeric glycoprotein B (gB) polyepitope protein in combination with human compatible TLR9 agonist CpG1018. The includes multiple minimal HLA class I-restricted CD8 + T cell epitopes from different antigens CMV. This...
Abstract There is now convincing evidence that the successful development of an effective CMV vaccine will require improved formulation and adjuvant selection capable inducing both humoral cellular immune responses. Here, we have designed a novel bivalent subunit based on CMV-encoded oligomeric glycoprotein B (gB) polyepitope protein in combination with human compatible TLR9 agonist CpG1018. The includes multiple minimal HLA class I-restricted CD8 + T cell epitopes from different antigens...
Degeneration of axons eliminates unwanted or damaged nerves from an organism as part normal neuronal development and injury, but is also a common feature in neurodegenerative disease neuropathies.Recently, Toll-like receptor (TLR) adaptor protein, sterile-alpha armadillo motif-containing protein (SARM), has shown to promote axon degeneration after injury (Wallerian degeneration) cell death.The comprises three domains: two central tandem motifs (SAM) flanked by N-terminal repeat motif (ARM)...