A5003322119- Immune Response and Inflammation
- Influenza Virus Research Studies
- Poxvirus research and outbreaks
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Virology and Viral Diseases
- NF-κB Signaling Pathways
- Virus-based gene therapy research
- Transgenic Plants and Applications
- Immune cells in cancer
- interferon and immune responses
The University of Queensland
2017-2025
Innate immunity relies on Toll-like receptors (TLRs) to detect pathogen-associated molecular patterns. The TIR (Toll/interleukin-1 receptor) domain-containing TLR adaptors TRIF (TIR adaptor-inducing interferon-β) and TRAM (TRIF-related adaptor molecule) are essential for MyD88-independent signaling. However, the structural basis of domain-based signaling remains unclear. Here, we present cryo-EM structures filaments formed by domains at resolutions 3.3 Å 5.6 Å, respectively. Both reveal...
Toll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged contributes to a range of inflammatory conditions. Structural information on the TLR cytoplasmic TIR (Toll/interleukin-1 receptor) domains and downstream adaptor proteins can help us develop inhibitors targeting this pathway. The small molecule o-vanillin has previously been reported as an inhibitor TLR2 signalling. To study its mechanism action, we tested binding domain MAL/TIRAP...
Vaccinia virus A46 is an anti-inflammatory and non-anti-apoptotic, two-domain member of the poxviral Bcl-2-like protein family that inhibits cellular innate immune response at level TIR domain-containing TLR adaptor proteins MAL, MyD88, TRAM TRIF. The mechanism interaction with its targets has remained unclear. domains MAL MyD88 have been shown to signal by forming filamentous assemblies. We show a clear concentration-dependent destruction both these assemblies means negative-stain electron...
Toll-like receptors (TLRs) detect pathogens and endogenous danger, initiating immune responses that lead to the production of proinflammatory cytokines.At same time, TLR-mediated inflammation is associated with a number pathological states, including infectious, autoimmune, inflammatory, cardiovascular cancer-related disorders.This dual role pathways has attracted widespread interest from pharmaceutical industries.Cytoplasmic signalling by TLRs starts their TIR (Toll/interleukin-1 receptor)...