A5101790009- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Natural Compounds
- Cancer, Lipids, and Metabolism
- Liver Diseases and Immunity
- Drug Transport and Resistance Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Climate Change and Health Impacts
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer therapeutics and mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Air Quality and Health Impacts
- Reproductive tract infections research
- Cancer, Hypoxia, and Metabolism
- Plant-based Medicinal Research
- Heavy Metal Exposure and Toxicity
- Pluripotent Stem Cells Research
- Cassava research and cyanide
- Medicinal Plants and Bioactive Compounds
Shuguang Hospital
2016-2025
Shanghai University of Traditional Chinese Medicine
2016-2025
Jilin University
2025
China Medical University
2023-2025
Chengdu University of Traditional Chinese Medicine
2021-2025
Hunan Provincial People's Hospital
2025
Hunan Normal University
2025
State Key Laboratory of Respiratory Disease
2025
Guangzhou Medical University
2025
Ministry of Education of the People's Republic of China
2018-2025
Hepatocyte ferroptosis promotes the pathogenesis and progression of liver fibrosis. Salvianolic acid B (Sal B) exerts antifibrotic effects. However, pharmacological mechanism target has not yet been fully elucidated. In this study, fibrosis was induced by CCl4 in wild-type mice hepatocyte-specific extracellular matrix protein 1 (Ecm1)-deficient mice, which were separately treated with Sal B, ferrostatin-1, sorafenib or cilengitide. Erastin- CCl4-induced hepatocyte models without Ecm1 gene...
Two new Securinega alkaloids, virosaines A (1) and B (2), were isolated from the twigs leaves of Flueggea virosa. The structures absolute configurations elucidated by means NMR, X-ray diffraction, CD analyses. Compounds 1 2 represent first examples alkaloids bearing a 7-oxa-1-azabicyclo[3.2.1]octane ring system, whose plausible biogenetic pathways also proposed.
Abstract This study aims to systematically determine the activities and expressions of cytochrome P450s (CYP) in hepatocellular carcinoma (HCC) patients support their optimal use personalized treatment HCC. Activities seven major drug-metabolizing CYP enzymes (CYP1A2, 2A6, 2C8, 2C9, 2D6, 2E1, 3A4) were determined tumors pericarcinomatous tissues harvested from 26 with hepatitis B virus-positive HCC using probe substrates. Protein mRNA levels these CYPs also measured isotope label-free...
Although hepatic progenitor cells (HPCs) are known to contribute cholestatic liver fibrosis (CLF), how Notch signaling modulates the differentiation of HPCs cholangiocytes in CLF is unknown. Thus, using a rat model that induced by bile duct ligation, we inhibited with DAPT. In vivo, CK19, OV6, Sox9, and EpCAM expression was increased significantly. after DAPT treatment reduced blocked cholangiocyte proliferation CLF. vitro, WB-F344 cell line sodium butyrate resulted mRNA protein EpCAM, but...
How to achieve stable co-delivery of multiple phytochemicals is a common problem. This study focuses on the development, optimization and characterization Huanglian-HouPo extract nanoemulsion (HLHPEN), with components co-delivery, enhance anti-ulcerative colitis (UC) effects. The formulation HLHPEN was optimized by pseudo-ternary phase diagram combined Box-Behnken design. physicochemical properties were characterized, its anti-UC activity evaluated in DSS-induced UC mice model. Based...
Although Periplaneta americana L. and its modern preparation, Kangfuxin liquid, have been extensively applied for ulcerative diseases in gastrointestinal tract (e.g., gastric ulcer (GU) colitis, the effective components potential mechanisms) remain unclear. In accordance with accumulating research evidences, relieving/exacerbating of GU is noticeably correlated to focal tissue programmed cell death. Herein, gastro-protective effects extract (PAE) fraction were assessed vitro vivo, involving...
Abstract Background The limited therapeutic outcomes of atherosclerosis (AS) have allowed, traditional Chinese medicine has been well established as an alternative approach in ameliorating AS and associated clinical syndromes. Clinically, Tongsaimai tablet (TSMT), a commercial patent approved by CFDA, shows obvious effect on treatment. However, its effective mechanism quality control still need thorough urgent exploration. Methods mice were orally administered with TSMT their serum was...
Abstract Background The frequently occurred chemotherapy-induced diarrhea (CID) caused by irinotecan (CPT-11) administration has been the most representative side-effects of CPT-11, resulting in chemotherapy suspension or failure. Our previous studies indicated that Gegen Qinlian formula exhibited a significant alleviation effect on CPT-11-induced diarrhea. However, referencing to Japanese Kampo medicine, TCM standard decoction would supply gap between ancient preparation application and...
Myocardial infarction represents a coronary artery ailment with the highest incidence and fatality rates among cardiovascular conditions. However, effective pharmacological interventions remain elusive. This study seeks to elucidate molecular mechanisms underlying effects of Ligusticum wallichii on myocardial through network pharmacology experimental validation. Initially, potential targets wallichii's active ingredients infarction-related were retrieved from databases. Subsequently, core...