A5011471035- Immune Cell Function and Interaction
- Salivary Gland Disorders and Functions
- Systemic Lupus Erythematosus Research
- Advanced Glycation End Products research
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Systemic Sclerosis and Related Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Diabetes and associated disorders
- Rheumatoid Arthritis Research and Therapies
- IgG4-Related and Inflammatory Diseases
- Eosinophilic Disorders and Syndromes
- Platelet Disorders and Treatments
- Sphingolipid Metabolism and Signaling
- Salivary Gland Tumors Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Autoimmune and Inflammatory Disorders Research
- Inflammasome and immune disorders
- Lymphatic System and Diseases
- Blood disorders and treatments
- Eosinophilic Esophagitis
- NF-κB Signaling Pathways
- Cellular Mechanics and Interactions
Huazhong University of Science and Technology
2014-2025
Tongji Hospital
2018-2025
Ministry of Education of the People's Republic of China
2014
Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune functions play vital role in ACS development; however, whether epigenetic modulation contributes to the regulation blood immune cells this disease has not been investigated.We conducted an epigenome-wide analysis with circulating identify differentially methylated genes ACS.We examined genome-wide methylation whole 102 patients and 101 controls using HumanMethylation450 array, externally replicated significant...
Chronic rejection that leads to diffuse narrowing and occlusion of graft vessels is the most important cause morbidity mortality following cardiac transplantation. The role underlying mechanism high-mobility group box 1 (HMGB1), as an established inflammatory mediator in acute rejection, remains poorly understood chronic rejection. Here, we assessed effects mechanisms HMGB1 on using single MHC Class II-mismatched mouse transplantation model. It was found increased accompanying with...
Objective:To investigate the role of IL-2 in balance Th17 and Tregs elucidate underlying mechanisms enhanced differentiation primary Sjögren's Syndrome (pSS) patients. Methods:This study involved 31 pSS patients, 7 Sicca patients healthy subjects. Treg cells were determined by flow cytometry immunohistochemistry. IL-6 levels assessed ELISA qPCR. p-STAT5 p-STAT3 salivary glands (SG) evaluated The binding STAT5 STAT3 to Il17a gene locus was measured chromatin-immunoprecipitation. Results:We...
Rheumatoid arthritis (RA) and osteoarthritis (OA) are common rheumatic disorders that primarily involve joints. The inflammation of the synovium can be observed in both two diseases. Synovial fibroblasts (SFs) play an important role inflammatory process synovium. functional states synovial heterogeneous, detailed transition their is still unclear. By using transcriptomic data SFs at a single-cell level, we found similar for RA OA. We also identified potential regulatory effects WNT signaling...
Great advancements have been made in understanding the pathogenesis of SS, but there remain unmet needs for effective and targeted treatments. Glandular extraglandular dysfunction SS is associated with autoimmune lymphocytic infiltration that invades epithelial structures affected organs. Regulatory T (Treg) cells are a subset CD4+ lymphocytes maintain self-tolerance during physiological conditions. Besides inhibiting excessive inflammation response by targeting various immune cell subsets...
Abstract The molecular mechanisms of primary Sjögren’s syndrome (pSS) are poorly understood. In this study, we explored the role IL-33/ST2 axis in development pSS. mouse model experimental syndrome, found that saliva flow rate at weeks 4 and 30 was preserved IL-33−/− ST2−/− mice, compared with wild-type mice. At week induction, histological score, anti-nuclear Ab levels, numbers Th1 B cells draining lymph nodes salivary gland were lower whereas Th17 regulatory T not changed. Primary...
NK cells participate in the development of human multiple sclerosis (MS) and mouse experimental autoimmune encephalomyelitis (EAE), but roles different cell subsets disease onset remain poorly understood. In this study, murine were divided into CD27 high low/− subsets. The subset was decreased increased lymphoid organs during pre-onset stage EAE. Compared with counterpart naïve mice, showed lower expression Ly49D, Ly49H NKG2D, less production IFN-γ, whereas similar above mentioned surface...
Cardiac allograft vasculopathy (CAV) charactered with aberrant remodeling and fibrosis usually leads to the loss of graft after heart transplantation. Our previous work has reported that extracellular high-mobility group box 1 (HMGB1) participated in CAV progression via promoting inflammatory cells infiltration immune damage. The aim this study was investigate involvement HMGB1 pathogenesis CAV/fibrosis potential mechanisms using a chronic cardiac rejection model mice. We found high levels...
Sphingomyelin synthase 1 (SMS1) has been reported to participate in hepatitis and atherosclerosis. However, its role autoimmune response is not clear. This study investigates the possible involvement of SMS1 B-cell activation lupus-like autoimmunity.SMS1 knockout animal model SLE patient samples were utilized. associated signal transduction detected by flow cytometry, confocal analysis western blotting. The expression B cells was measured real-time qPCR.SMS1 deficiency suppressed culture,...
This study aimed to preliminarily address the levels of decorin (DCN, a critical component extracellular matrix) and its potential roles in primary Sjögren's syndrome (pSS).DCN were determined salivary glands experimental SS (ESS) mice pSS patients by RNA sequencing, bioinformatics analysis, or immunohistochemical staining. Its correlation with interested genes co-localization putative receptor was studied patients. In addition, on gland epithelium macrophages tested exogenous administration...
Abstract Objectives To explore clinical features of autoimmune inflammatory rheumatic disease (AIRD) patients with Pneumocystis jirovecii pneumonia (PJP) and identify potential risk factors prognostic factors. Methods AIRD who had respiratory symptoms underwent P. detection were identified from the database in our department November 2018 to October 2020. These categorized into PJP non-PJP groups according diagnostic criteria PJP. Univariate multivariate analyses conducted. Results A total...
Evidences have suggested that Sjogren's syndrome (SS) is associated with viral infection. The aim of this study was to investigate the involvement respiratory poly(I:C) in pathogenesis SS and potential mechanisms using a SS-like NOD/ShiLtJ (NOD) mouse model. 5-week female NOD mice were intratracheally administered every other day for 5 times mimic Pilocarpine induced saliva secretion determined 8 days. Submandibular glands (SMG) lungs harvested detection pathological changes. We found...