A5061248522- Immune Cell Function and Interaction
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Advanced Glycation End Products research
- RNA Interference and Gene Delivery
- IL-33, ST2, and ILC Pathways
- Reproductive System and Pregnancy
- Diabetes and associated disorders
- Cytokine Signaling Pathways and Interactions
- Pancreatic function and diabetes
- Monoclonal and Polyclonal Antibodies Research
- NF-κB Signaling Pathways
- Eosinophilic Esophagitis
- Neuroinflammation and Neurodegeneration Mechanisms
- Virus-based gene therapy research
- interferon and immune responses
- Immune cells in cancer
- Macrophage Migration Inhibitory Factor
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pharmacological Effects of Natural Compounds
- Cell Adhesion Molecules Research
- Adenosine and Purinergic Signaling
- Xenotransplantation and immune response
- Cytomegalovirus and herpesvirus research
Huazhong University of Science and Technology
2014-2024
Ministry of Education of the People's Republic of China
2012-2018
Saudi Center for Organ Transplantation
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
Beth Israel Deaconess Medical Center
2014
Harvard University
2014
Tongji Hospital
2003-2013
Union Hospital
2013
Kanazawa Medical University
2013
Wuhan University
2012
Macrophages perform key functions in tissue homeostasis that are influenced by the local environment. Within tumor microenvironment, tumor-associated macrophages can be altered to acquire properties enhance growth. Here, we found lactate, a metabolite high concentration within anaerobic environment, activated mTORC1 subsequently suppressed TFEB-mediated expression of macrophage-specific vacuolar ATPase subunit ATP6V0d2. Atp6v0d2-/- mice were more susceptible growth, with enhanced...
Crohn's disease (CD) is characterized by the activation of Th1 and Th17 cells deficiency regulatory T (Tregs), leading to intestine tissue injury destruction. As a novel cytokine interleukin (IL)-1 family, role underlying mechanisms IL-33 in CD remain poorly understood. Here, we assess effects on trinitrobenzene sulfonic acid (TNBS)-induced experimental colitis that mimics human CD. We found levels were increased TNBS-treated mice, whereas recombinant (rIL-33) administration substantially...
Macroautophagy/autophagy is a conserved ubiquitous pathway that performs diverse roles in health and disease. Although many key, widely expressed proteins regulate autophagosome formation followed by lysosomal fusion have been identified, the possibilities of cell-specific elements contribute to autophagy machinery not explored. Here we show macrophage-specific isoform vacuolar ATPase protein ATP6V0D2/subunit d2 dispensable for lysosome acidification, but promotes completion via promotion...
Liver ischemia–reperfusion (I/R) injury is a multifactorial process that affects graft function after liver transplantation. Inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and IL-18, have been shown to play key roles in the pathophysiology of I/R injury. Studies indicated NALP3 (NACHT domain, leucine-rich repeat [LRR] pyrin domain [PYD]-containing protein-3) inflammasome pivotal processing releasing IL-1β IL-18. The aim this study was test whether...
OBJECTIVE—The implication of innate immunity in type 1 diabetes development has long been proposed. High-mobility group box (HMGB1), an evolutionarily conserved chromosomal protein, was recently recognized to be a potent inflammatory mediator when released extracellularly. We sought test the hypothesis that HMGB1 acts as immune implicated pathogenesis. RESEARCH DESIGN AND METHODS—Eight- and 12-week-old NOD mice were treated with neutralizing antibody once week until 25 weeks age monitored...
Graft quality, comprised of ischaemia-reperfusion injury (IRI) and surgical manipulation, is one the major factors influencing transplant rejection. High-mobility group box 1 (HMGB1), a known activator innate immunity, has been associated with tissue-generated immunological 'danger' signals; however, its role in renal IRI not clear.Renal was induced by clamping left pedicle for 60 min uninephrectomized BALB/c mice. Rabbit anti-mouse HMGB1 antibody given intraperitoneally 24 h 30 before...
Abstract As an H+-gated subgroup of the degenerin/epithelial Na+ channel family, acid-sensing ion channels (ASICs) were reported to be involved in various physiological and pathological processes neurons. However, little is known about role ASICs function dendritic cells (DCs). In this study, we investigated expression mouse bone marrow-derived DCs their possible DCs. We found that ASIC1, ASIC2, ASIC3 are expressed at mRNA protein levels, extracellular acid can evoke ASIC-like currents also...
Abstract Background High mobility group protein box 1 (HMGB1) is a DNA binding located in nucleus. It released into extracellular fluid where it acts as novel proinflammatory cytokine which interacts with Toll like receptor 4 (TLR4) to activate nuclear factor-κB (NF-κB). This sequence of events involved tumor growth and progression. However, the effects HMGB1, TLR4 NF-κB on epidermal tumors remain unclear. Methods Human specimens were obtained from 96 patients. Immunohistochemistry was used...
In Th (T helper) 1/Th2 balance in response to signals given during donor antigen presentation, induction of allograft prolongation is more often related Th2-type than with Th1-type immunity. Here, we examined the effect interleukin (IL)-33, a novel member IL-1 family, on cardiac survival mice.Mice heterotopic transplants were performed sequential recipient sacrifice at anticipated time points examine immunoregulatory action IL-33 mice.In vitro Th1-polarized CD4 T cells did not express ST2L;...
The inflammatory mediator high-mobility group box 1 (HMGB1) plays a critical role in the pathogenesis of human multiple sclerosis (MS) and mouse experimental autoimmune encephalomyelitis (EAE). Glycyrrhizin (GL), glycoconjugated triterpene extracted from licorice root, has ability to inhibit functions HMGB1; however, GL's function against EAE not been thoroughly characterized date. To determine benefit GL as modulator neuroinflammation, we used an vivo study examine effect on along with...
Given the importance of Jak2 in cell signaling, a critical role for immune cells especially dendritic (DCs) has long been proposed. The exact function DCs, however, remained poorly understood as deficiency leads to embryonic lethality. Here we established adult Cre(+/+)Jak2(fl/fl) mice by tamoxifen induction. Loss significantly impaired DC development manifested reduced BMDC yield, smaller spleen size and percentage DCs total splenocytes. was also crucial capacity mediate innate response....
Chronic rejection that leads to diffuse narrowing and occlusion of graft vessels is the most important cause morbidity mortality following cardiac transplantation. The role underlying mechanism high-mobility group box 1 (HMGB1), as an established inflammatory mediator in acute rejection, remains poorly understood chronic rejection. Here, we assessed effects mechanisms HMGB1 on using single MHC Class II-mismatched mouse transplantation model. It was found increased accompanying with...