A5061061871- Immune Cell Function and Interaction
- Circular RNAs in diseases
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Eosinophilic Esophagitis
- RNA Interference and Gene Delivery
- Macrophage Migration Inhibitory Factor
- MicroRNA in disease regulation
- Mast cells and histamine
- Chemokine receptors and signaling
- Dermatological and Skeletal Disorders
- Inflammasome and immune disorders
Huazhong University of Science and Technology
2010-2019
Central Hospital of Wuhan
2018-2019
Crohn's disease (CD) is characterized by the activation of Th1 and Th17 cells deficiency regulatory T (Tregs), leading to intestine tissue injury destruction. As a novel cytokine interleukin (IL)-1 family, role underlying mechanisms IL-33 in CD remain poorly understood. Here, we assess effects on trinitrobenzene sulfonic acid (TNBS)-induced experimental colitis that mimics human CD. We found levels were increased TNBS-treated mice, whereas recombinant (rIL-33) administration substantially...
Liver ischemia–reperfusion (I/R) injury is a multifactorial process that affects graft function after liver transplantation. Inflammatory cytokines, such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and IL-18, have been shown to play key roles in the pathophysiology of I/R injury. Studies indicated NALP3 (NACHT domain, leucine-rich repeat [LRR] pyrin domain [PYD]-containing protein-3) inflammasome pivotal processing releasing IL-1β IL-18. The aim this study was test whether...
The induction of immune tolerance is still a formidable challenge in organ transplantation. Dendritic cells (DCs) play an important role orchestrating responses by either mediating protective or inducing antigen specific tolerance. Previous studies demonstrated that the fms-like tyrosine kinase 3 receptor (Flt3) and its ligand (Flt3L) essential regulation DC commitment development. Here, we report synergic effect between Flt3L low-dose rapamycin (Rapa) protection allograft rejction. It was...
Dendritic cells (DCs) are key components of the immune system, serving as antigen‐presenting to activate adaptive immunity. Whereas mature DCs promote responses, immature induce or maintain immunological tolerance by downregulating T‐cell responses. Therefore, potent antigen (Ag)‐presenting in system. MicroRNAs noncoding RNAs that posttranscriptionally regulate mRNA binding 3′‐untranslated region (UTR) these molecules, modulating their expression. Many recent studies have suggested a...