A5026549258- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Immune Cell Function and Interaction
- Platelet Disorders and Treatments
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Inflammation biomarkers and pathways
- Kawasaki Disease and Coronary Complications
- Diabetes and associated disorders
- Renal Diseases and Glomerulopathies
- Systemic Sclerosis and Related Diseases
- Otitis Media and Relapsing Polychondritis
- Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Inflammatory Myopathies and Dermatomyositis
- Viral Infections and Immunology Research
- Family and Disability Support Research
- T-cell and B-cell Immunology
- Infective Endocarditis Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Spondyloarthritis Studies and Treatments
- Connective Tissue Growth Factor Research
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
Shanghai Jiao Tong University
2015-2025
Ruijin Hospital
2017-2025
Renji Hospital
2006-2024
NIHR Manchester Biomedical Research Centre
2023
University of Manchester
2023
Manchester Academic Health Science Centre
2023
Hebei Normal University
2022-2023
Beijing International Studies University
2022
Shandong University of Traditional Chinese Medicine
2012-2014
Changhai Hospital
2008
Adult-onset Still's disease (AOSD) is a systemic inflammatory characterized by neutrophilia and NLRP3 inflammasome macrophage activation. We investigated the role of neutrophil extracellular traps (NETs) in pathogenesis AOSD, explored effect NETs on activating proinflammatory macrophages. The sera 73 AOSD patients 40 healthy controls were used to detect level cell-free DNA NET-DNA complexes. NET formation ex vivo was analyzed using immunofluorescence flow plates. activation THP-1 cells...
Abstract Background: The aim of the study was to determine prevalence and clinical associations antiphosphatidylserine/prothrombin antibodies (aPS/PT) with thrombosis pregnancy loss in Chinese patients antiphospholipid syndrome (APS) seronegative APS (SNAPS). Methods: One hundred eighty six (67 primary, 119 secondary), 48 SNAPS, 176 disease controls (79 systemic lupus erythematosus [SLE], 29 Sjogren’s [SS], 30 ankylosing spondylitis [AS], 38 rheumatoid arthritis [RA]) 90 healthy donors were...
Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of remains largely unknown. Here we show in animal model that administration leads to hepatic excessive neutrophil leukocyte infiltration extracellular trap (NET) formation liver tissue. Ferritin-induced NET depends on expression peptidylarginine deiminase 4 elastase reactive oxygen species production....
Abstract Background Despite expansion in the 2006 Sydney antiphospholipid syndrome (APS) classification criteria to include IgG/IgM anti-β2-glycoprotein (aβ2GPI) antibodies addition anti-cardiolipin (aCL) and lupus anticoagulant (LAC), some individuals with clinical features of APS remain seronegative (seronegative or SNAPS) are at risk recurrent thrombosis pregnancy morbidities. Our aim was assess value “non-criteria” aPL detect these SNAPS patients. Methods One hundred ninety-two patients,...
Abstract Aberrant coagulation and thrombosis are associated with severe COVID-19 post-SARS-CoV-2 infection, yet the underlying mechanism remains obscure. Here we show that serum levels of SARS-CoV-2 envelope (E) protein disorders patients, intravenous administration E is able to potentiate in mice. Through pull-down mass spectrometry, find CD36, a transmembrane glycoprotein, directly binds mediates hyperactivation human mouse platelets through p38 MAPK-NF-κB signaling pathway. Conversely,...
T-614 is a novel oral antirheumatic agent for the treatment of rheumatoid arthritis. Whether it has immunomodulatory or disease-modifying properties and its mechanism action are largely undetermined. Rats with collagen-induced arthritis (CIA) were treated (5 20 mg/kg) daily. Animals receiving methotrexate (1 mg/kg every 3 days) nonsteroidal anti-inflammatory nimesulide (10 per day) used as controls. A combination therapy group was both T-614(10 days). Hind paw swelling evaluated radiographic...
Abstract Objective To assess the efficacy and safety of T‐614 versus methotrexate (MTX) in patients with active rheumatoid arthritis (RA). Methods In this multicenter, double‐blind trial, 489 randomly received either 25 mg/day for first 4 weeks 50 subsequent 20 (group 1, n = 163), 24 2, or MTX 10 mg/week 15 (n 163). Clinical laboratory parameters were analyzed at baseline 4, 10, 17, weeks. Results After treatment, American College Rheumatology 20% improvement criteria response rate group 2...
Systemic lupus erythematosus (SLE) is characterized by the uncontrolled production of inflammatory cytokines, among which type I interferon (IFN) recognized as a crucial pathogenic factor. The expression microRNA-146a (miR-146a) reduced in white blood cells SLE patients and accounts for their overactivated responses. However, mechanism reduction miR-146a still not fully understood. This study was undertaken to test whether key cytokine, IFN, responsible dysregulation SLE.Gene protein...
Dysfunction of the endothelium is regarded as an important factor in pathogenesis vascular disease diabetes mellitus (DM). Unfortunately, prevention progression complications DM remains pessimistic. Ferulic acid and astragaloside IV, isolated from traditional Chinese medicine Angelica sinensis Radix astragali respectively, exhibit potential cardio-protective anti-hyperglycemic properties. In present study, we investigated protective effects underlying mechanism ferulic IV against endothelial...
Anti-β2GP1 (β2-glycoprotein 1) antibodies are the primary pathogenic antibody to promote thrombosis in antiphospholipid syndrome (APS), yet underlying mechanism remains obscure. We aimed explore intracellular pathway that mediated platelet activation. Platelets were isolated from patients with APS and subjected RNA sequencing. Platelet aggregation, release of granules, spreading, clot retraction detected evaluate purified anti-β2GP1 total IgG healthy donors stimulate platelets with/without...
Previous studies have revealed that several micro-organisms, especially DNA viruses, been associated with adult-onset Still's disease (AOSD). However, there are no on the relationship between presence of viral infections in AOSD patients occurrence and reactivation. In present study, we aimed to investigate antibodies against virus, virus load nucleic acid sensors patients. Anti-viral were measured by enzyme-linked immunosorbent assay (ELISA) plasma samples from 100 70 healthy controls...
Abstract CCN1, an extracellular protein also known as cysteine-rich 61 (Cyr61), is a novel pro-inflammatory factor involved in the pathogenesis of rheumatoid arthritis. As inflammatory disease, psoriasis characterized by keratinocyte activation-induced epidermal hyperplasia and cytokine-mediated inflammation. We demonstrated our previous study that CCN1 promoted activation psoriasis. However, role regulating inflammation still unknown. Here, we showed increased cytokine IL-1β production...
The burden of obesity and associated cardiometabolic diseases have been considered as an important risk factor for lupus patients. Therefore, the links between autoimmunity were questioned, involvement in rise autoimmune conditions was strongly suggested. Hydroxychloroquine is known one most fascinating synthetic antimalarial drugs, presently among commonly employed medicines clinical treatment rheumatic diseases. has suggested to beneficial effects on lipids insulin sensitivity, which may...
The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still’s (AOSD) an autoinflammatory characterized by life-threatening complications. Systemic hyperinflammation and cytokine storm play critical role in the pathogenesis both COVID-19 AOSD. We aimed to compare similarities differences focusing on ferritin levels between severe active A literature search was performed using databases PubMed, EMBASE, Web Science collect including IL-1β,...
Adult-onset Still's disease (AOSD) is a rare but clinically well-known auto-inflammatory disorder. Cytokine storm, the hallmark of AOSD, mediated by neutrophil hyperactivation and enhanced extracellular trap (NET) formation. Type I interferons (IFNs), having primary role in initiation proinflammation responses, can induce subsequent inflammatory cytokine production. However, type IFNs AOSD unclear. Indeed, high levels IFN-α IFN-β expression are presented patients. In this investigation,...
Adult-onset Still's disease (AOSD) is a systemic autoinflammatory characterized by innate immune system activation, with high risk for macrophage activation syndrome (MAS). MAS development associated monocyte/macrophage and cytokine storm. Monocytes consist of three different subsets, classical monocytes (CMs, CD14
To evaluate the effectiveness of 2023 ACR/EULAR criteria for antiphospholipid syndrome (APS) in a Chinese cohort, and compare them with Sapporo revised criteria.
Interleukin (IL)-37 has been known to play an immunosuppressive role in various inflammatory disorders, but whether it participates the regulation of pathogenesis adult-onset Still’s disease (AOSD) not investigated. In this study, we examined serum IL-37 levels and their clinical association with AOSD, explored anti-inflammatory effects on peripheral blood mononuclear cells (PBMCs) from patients AOSD. Blood samples were collected 62 AOSD 50 healthy control subjects (HC). The determined using...
Systemic Lupus Erythematosus (SLE) is a complex and heterogeneous autoimmune disease mediated by quantities of autoantibodies in which anti-double-stranded DNA (anti-dsDNA) antibodies are important. Besides, glycosylation one the most commonly post-translational modifications antibodies. The association anti-dsDNA SLE activity still unknown.We enrolled 101 consecutive treatment-naïve patients with positive from Department Rheumatology Immunology at Ruijin Hospital, Shanghai, between 2017...
Importance Anti–double-stranded DNA (dsDNA) antibody has been reported to have a close relationship with systemic lupus erythematosus (SLE) flares and participates in the pathogenesis of nephritis (LN) as well causing damage other organs. However, whether early use mycophenolate mofetil (MMF) could prevent SLE is not clear. Objective To assess efficacy safety MMF plus prednisone hydroxychloroquine sulfate compared alone patients SLE. Design, Setting, Participants This investigator-initiated,...