A5070670767- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Inflammatory Myopathies and Dermatomyositis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Mesenchymal stem cell research
- Systemic Sclerosis and Related Diseases
- Immune Cell Function and Interaction
- Salivary Gland Disorders and Functions
- Eosinophilic Disorders and Syndromes
- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- Inflammatory mediators and NSAID effects
- Telomeres, Telomerase, and Senescence
- Reproductive System and Pregnancy
- Hepatitis C virus research
- MicroRNA in disease regulation
- dental development and anomalies
- Inflammasome and immune disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Oral and Maxillofacial Pathology
- Ubiquitin and proteasome pathways
- Immunotherapy and Immune Responses
- Osteoarthritis Treatment and Mechanisms
First Affiliated Hospital Zhejiang University
2012-2025
Shandong First Medical University
2025
Tongren Hospital
2024
Shanghai Jiao Tong University
2024
Zhejiang University
2015-2024
Seoul National University
2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2024
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2024
Shanghai University of Traditional Chinese Medicine
2024
Shanxi Agricultural University
2024
Berberine (BBR), an alkaloid isolated from
The putative tumor suppressor microRNA let-7c is extensively associated with the biological properties of cancer cells. However, potential involvement in differentiation mesenchymal stem cells has not been fully explored. In this study, we investigated influence hsa-let-7c (let-7c) on proliferation and human dental pulp-derived (DPMSCs) treated insulin-like growth factor 1 (IGF-1) via flow cytometry, CCK-8 assays, alizarin red staining, real-time RT-PCR, western blotting. general,...
PD-1+CXCR5-CD4+T peripheral helper (Tph) cells, a recently identified T cell subset, are proven to promote B responses and antibody production in rheumatoid arthritis, but their role the pathogenesis of SLE is unknown. We explored Tph lupus disease development.This cohort study included 68 patients with 41 age- sex-matched healthy individuals. The frequency cells was analysed blood by flow cytometry. Inducible T-cell costimulator, CD38, MHC-II, IL-21, CXCR3 CCR6 expression were measured...
Background Polymyalgia rheumatica (PMR) is a common inflammatory disease in elderly persons whose mechanism of pathogenesis has not been elucidated. Glucocorticoids are the main first-line treatments but result numerous side effects. Therefore, there need to explore pathogenetic factors and identify possible glucocorticoid-sparing agents. We aimed study features assess efficacy safety Janus tyrosine kinase (JAK)-inhibitor tofacitinib patients with PMR. Methods findings recruited...
Introduction Population expansion and economic development increased global greenhouse gas emissions, leading to serious environmental degradation. China, the world's largest developing country promoter of “Belt Road Initiative” (BRI), accounts for 28.8% world"s total energy carbon emissions. How reduce consumption achieve “double carbon” target (i.e., peaking neutrality) promote implementation Green BRI is still a challenge that China needs face. Methods We evaluated China's emissions using...
Abstract Foxp3+ regulatory T cells (Treg) playing a crucial role in the maintenance of immune tolerance and prevention autoimmune diseases consist thymus-derived naturally occurring CD4+Foxp3+ Treg (nTreg) those that can be induced ex vivo with TGF-β (iTreg). Although both subsets share similar phenotypes functional characteristics, they also have potential biologic differences on their biology. The iTreg regulating B remains unclear so far. suppression assays activation, proliferation, Abs...
Objectives Combination therapy with mycophenolate mofetil, tacrolimus and steroids are effective in achieving complete remission lupus nephritis (LN). uniquely downregulated caspase-1 compared monotherapies, which can cleave gasdermin D (GSDMD) was recently identified as the pyroptosis executioner. We therefore investigated whether combination enabled suppression of caspase-1/GSDMD-mediated LN. Methods Expression activation GSDMD were detected kidney specimens human mouse LN using...
Abstract Doxorubicin (DOX) is a popular and potent anticancer drug, but its cardiotoxicity limits clinical application. Shikonin has wide range of biological functions, including antioxidant anti-inflammatory effects. The aim this study was to investigate the effects shikonin on DOX-induced cardiac injury identify underlying mechanisms. Mice receiving showed reduced response enhanced function after DOX administration. significantly attenuated oxidative damage, inflammation accumulation...
Tong-Xie-Yao-Fang (TXYF) has been widely used for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) in traditional Chinese medicine. However, its mechanism action IBS-D remains to be fully understood. Recent reports have shown that Clostridium species gut can induce 5-HT production colon, which then contributes IBS-D. Due wide use TXYF clinical and close relationship between microbiota IBS-D, we hypothesize treats by modulating regulating colonic levels. In this study,...
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune disease and supposed to have both genetic environmental backgrounds. Plenty of studies demonstrated the roles long non-coding RNAs (lncRNAs) in initiation development RA. Numerous lncRNAs been found be dysregulated RA correlated with activity RA, which indicates potential diagnostic lncRNAs. In addition working as biomarkers for participate many specific pathological processes including inflammation, aberrant proliferation,...
Apremilast is a novel phosphodiesterase 4 (PDE4) inhibitor suppressing immune and inflammatory responses. We assessed the anti-inflammatory effects of in type II collagen (CII)-induced arthritis (CIA) mouse model. To determine whether can ameliorate onset this model, was given orally at day 14 after CII immunization. Bone erosion measured by histological micro-computed tomographic analysis. Anti-mouse antibody levels were enzyme-linked immunosorbent assay, Th17, Th1 cells, CD4+Foxp3+...
We examined the United States National Health and Nutrition Examination Survey (NHANES) database to determine factors associated with rheumatoid arthritis (RA) in adults 20 55 years of age.NHANES data collected between 2007 2014, excluding 2011-2012 period, were used. Subjects divided into those without RA. Demographic, clinical, lifestyle compared groups.After applying inclusion/exclusion criteria, 8,789 persons included study (8,483 RA, 306 RA). Multivariable analysis indicated that...
Abstract MicroRNA let‐7 family acts as the key regulator of differentiation mesenchymal stem cells (MSCs). However, influence let‐7b on biological characteristics from apical papilla (SCAPs) is still controversial. In this study, expression hsa‐let‐7b was obviously downregulated during osteogenic SCAPs. SCAPs were then infected with or inhibitor lentiviruses. The proliferation ability determined by CCK‐8 and flow cytometry. odonto/osteogenic capacity analyzed alkaline phosphatase (ALP)...
The aim of this work is to investigate the clinical and radiological characteristics elderly rheumatoid arthritis compare outcomes between two subgroups, elderly- young-onset (EORA YORA, respectively). We conducted a retrospective case-control study on patients in our medical center. EORA was defined as patient whose onset age above 60. A total 142 were admitted, with 79 63 YORA group. Inflammatory parameters including C-reactive protein, D-dimer, serum ferritin, platelet count levels all...