A5103044083- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Inflammation biomarkers and pathways
- Inflammasome and immune disorders
- Otitis Media and Relapsing Polychondritis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Kawasaki Disease and Coronary Complications
- Systemic Lupus Erythematosus Research
- Microbial Metabolites in Food Biotechnology
- Family and Disability Support Research
- Cytomegalovirus and herpesvirus research
- Materials Engineering and Processing
- Coal Combustion and Slurry Processing
- Magnesium in Health and Disease
- Parkinson's Disease Mechanisms and Treatments
- Immunodeficiency and Autoimmune Disorders
- Educational Technology and Assessment
- Educational Technology and Pedagogy
- Catalysis for Biomass Conversion
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Blood Coagulation and Thrombosis Mechanisms
- Peripheral Neuropathies and Disorders
- Therapeutic Uses of Natural Elements
- Polysaccharides Composition and Applications
Ruijin Hospital
2020-2025
Shanghai Jiao Tong University
2019-2025
Guangxi University
2025
Shandong University
2024
Auckland University of Technology
2024
Wannan Medical College
2023-2024
Sun Yat-sen University
2023
Taizhou First People's Hospital
2023
Shanghai Chest Hospital
2021
Hyperferritinemic syndrome, an overwhelming inflammatory condition, is characterized by high ferritin levels, systemic inflammation and multi-organ dysfunction, but the pathogenic role of remains largely unknown. Here we show in animal model that administration leads to hepatic excessive neutrophil leukocyte infiltration extracellular trap (NET) formation liver tissue. Ferritin-induced NET depends on expression peptidylarginine deiminase 4 elastase reactive oxygen species production....
Aberrant activity of bone resorbing osteoclasts plays a key role in the development osteoporosis and cancer metastasis. The identification novel specific targets will be helpful for new therapeutic strategies metastasis lung cancer. Herein, we examined microRNAs tumor cell-derived exosomes to investigate communication between environment cells. TCGA database analysis showed that level miR-17-5p increased non-small cell tissues compared with non-tumor tissues. To function inducing...
The catastrophic outbreak of coronavirus disease 2019 (COVID-19) is currently a public emergency. Adult-onset Still’s (AOSD) an autoinflammatory characterized by life-threatening complications. Systemic hyperinflammation and cytokine storm play critical role in the pathogenesis both COVID-19 AOSD. We aimed to compare similarities differences focusing on ferritin levels between severe active A literature search was performed using databases PubMed, EMBASE, Web Science collect including IL-1β,...
Adult-onset Still's disease (AOSD) is a rare but clinically well-known auto-inflammatory disorder. Cytokine storm, the hallmark of AOSD, mediated by neutrophil hyperactivation and enhanced extracellular trap (NET) formation. Type I interferons (IFNs), having primary role in initiation proinflammation responses, can induce subsequent inflammatory cytokine production. However, type IFNs AOSD unclear. Indeed, high levels IFN-α IFN-β expression are presented patients. In this investigation,...
Adult-onset Still's disease (AOSD) is a systemic autoinflammatory characterized by innate immune system activation, with high risk for macrophage activation syndrome (MAS). MAS development associated monocyte/macrophage and cytokine storm. Monocytes consist of three different subsets, classical monocytes (CMs, CD14
Abstract Background Population-based studies have shown that adequate magnesium intake is associated with a lower risk of stroke and all-cause mortality. Whether important for reducing mortality after remains unclear. Methods We analyzed data from 917 patients self-reported history the National Health Nutrition Examination Survey (NHANES) 2007–2018. The total was calculated by summing dietary supplements, then adjusting energy according to nutrient density method. Mortality status determined...
Adult-onset Still's disease (AOSD) is an autoinflammatory with multisystem involvement. Early identification of patients severe complications and those refractory to glucocorticoid crucial improve therapeutic strategy. Exaggerated neutrophil activation enhanced formation extracellular traps (NETs) in AOSD were found be closely associated etiopathogenesis. In this study, we aim investigate, our knowledge for the first clinical value circulating NETs by machine learning distinguish organ...
<title>Abstract</title> Antiphospholipid syndrome (APS) serves as a prototypical disease model for investigating immune tolerance breakdown in systemic autoimmunity of B cell. Single-cell RNA and V(D)J repertoire sequencing on paired bone marrow peripheral blood from untreated primary APS patients enabled an integral “central-to-periphery” cell blueprint at single-cell resolution, wherein we observed substantial increase subsets across nearly all developmental stages. Notably, interferon...
As a carbon-neutral and renewable raw material, cellulose can be transformed into biomass fuels to reduce the dependence on fossil carbon dioxide emissions. In view of harsh reaction conditions, low selectivity product, easy deactivation catalyst, this study studied use photothermal catalytic technology convert bio-oil rich in levulinic acid. It was discovered that synergistic effect between heating photocatalysis is present degradation. Different metals were loaded nanotubes doped with...
In order to reduce energy consumption of weak black liquor concentration and the emission sulfur oxide carbon dioxide, coal water slurry (BLCWS) prepared aiming consume directly is studied in this paper. The study found that BLCWS with 66.5% solid content based on low oxygen ratio presents good fluidity static stability. under condition content, 10 min grinding time, 1% additive amount achieved best forming performance. water-liberating rates are as 0.75% after standing for 25 days. apparent...
Macrophage activation syndrome (MAS) is believed to be the result of inappropriate proliferation and mononuclear phagocytic system. Adult-onset Still's disease (AOSD) characterized by neutrophil a cytokine storm, which can lead its severe potentially life-threatening complication MAS. RNA sequencing revealed that neutrophils may play distinct enhanced role in innate immunity AOSD patients with MAS (AOSD-MAS). In CpG-induced secondary hemophagocytic lymphohistiocytosis (HLH) model, depletion...
Objective Adult‐onset Still’s disease (AOSD) is a severe autoinflammatory disease. Neutrophil activation with enhanced neutrophil extracellular trap (NET) formation involved in the pathogenesis of AOSD. Functional leukocyte immunoglobulin‐like receptor A3 (LIR‐A3; gene name LILRA3 ) has been reported to be associated many autoimmune diseases. We aimed investigate association susceptibility and Methods The deletion polymorphism its tagging single‐nucleotide rs103294 were genotyped 164...
Polygonatum cyrtonema Hua polysaccharides (PCP) have beneficial effects on lipid metabolism and oxidative stress. Here, PCP extraction was optimized using response surface methodology (RSM), the antioxidant lipid-lowering of its main component, PCP1, were evaluated in vitro. The maximum yield 11.05% at an temperature 72°C, liquid-to-solid ratio 21, time 96 min, two rounds. PCP1 purified by column chromatography showed significant scavenging activity against 1,1-diphenyl-2-picrylhydrazyl...
Macrophage activation syndrome (MAS) is a potentially fatal consequence of adult-onset Still's disease (AOSD), driven by cytokine storm. Efficient early diagnosis AOSD-associated MAS requires sensitive and specific biomarker. In this study, we demonstrated that pentraxin 3 (PTX3), an acute phase protein, was associated with AOSD activity served as biomarker for AOSD-MAS. PTX3 levels were significantly increased in patients compared to other autoimmune diseases healthy controls. Plasma showed...
Liver damage is a common manifestation and can be life-threatening in adult-onset Still's disease (AOSD), an autoinflammatory disease. The hallmark of AOSD activation neutrophils, whose infiltration liver suspected to promote tissue injury. Here we aimed identify candidate biomarker validate its association with AOSD.Transcriptome analysis neutrophils from treatment-naïve active patients healthy donors was performed. Lipocalin-2 (LCN2) expression assessed plasma biopsies AOSD. correlations...
Rheumatoid arthritis (RA), a chronic systemic autoimmune disease, is characterized by synovitis and progressive damage to the bone cartilage of joints, leading disability reduced quality life. This study was randomized clinical trial comparing outcomes between withdrawal dose reduction tofacitinib in patients with RA who achieved sustained disease control.
Objective: Adult-onset Still's disease (AOSD) is a systemic disorder commonly accompanied by liver involvement. This study aims to illustrate the detailed information of abnormalities in patients with AOSD and evaluate impact on prognosis. Methods: A total number 128 hospitalized patients, who met Yamaguchi criteria Department Rheumatology Immunology, Ruijin Hospital from July 2016 August 2019 were consecutively enrolled followed up. The demographic characteristics, clinical features,...
To describe the detailed characteristics and explore potential risk factors of relapses in patients with adult-onset Still's disease (AOSD).We enrolled AOSD admitted to Department Rheumatology Immunology, Ruijin Hospital from August 2016 September 2019. Kaplan-Meier curves log rank test were used estimate cumulative relapse probability persistent remission rate before first occurrence relapse. The multivariate Cox proportional hazard method was utilized identify associated AOSD.A total 122 a...
Abstract Objective To explore whether inactivated coronavirus disease 2019 vaccine influences the profile of prothrombotic autoantibodies and induces thrombotic events in primary APS patients. Methods We enrolled 39 patients who received two doses severe acute respiratory syndrome 2 (SARS-CoV-2) (BBIBPCorV, Sinopharm, Beijing, China) voluntarily this prospective cohort. Prothrombotic were determined before vaccination 4 weeks after second dose vaccination. Thrombotic disorders evaluated via...
Circulating tumor DNA (ctDNA), a fraction of cell-free (cfDNA) in the circulatory system, is released from cells and thus carries tumor-specific genetic signatures. Using blood-derived ctDNA to detect somatic mutations has shown great value guiding cancer targeted therapy. Isolation detection efficiencies are key factors affecting performance detection. To optimize standardize our clinical practice, this study, we analyzed isolation efficiency four commercial cfDNA purification kits: QIAamp...
Low DJ-1 protein level caused by gene mutation leads to autosomal recessive Parkinson's disease (PD) due impaired antioxidative activity. In sporadic PD patients, although mutations were rarely found, lower of was also reported. Dysregulation expression might contribute low level. Since promoter is the most important element initiate expression, whether polymorphisms in result dysregulation thus lead and cause worth exploring. region sequenced a Chinese cohort evaluate possible links between...