A5039885432- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Neurofibromatosis and Schwannoma Cases
- Gastrointestinal Tumor Research and Treatment
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Sarcoma Diagnosis and Treatment
- Mechanisms of cancer metastasis
- Pancreatic and Hepatic Oncology Research
- Microtubule and mitosis dynamics
- Cancer Research and Treatments
- Chromatin Remodeling and Cancer
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
- Immune cells in cancer
- Cutaneous Melanoma Detection and Management
- RNA Research and Splicing
- Caveolin-1 and cellular processes
- Metastasis and carcinoma case studies
Liaoning Cancer Hospital & Institute
2019-2025
Dalian University of Technology
2022-2025
China Medical University
2019-2025
The lncRNA NEAT1 has been shown to promote the progression of several cancers, containing laryngeal squamous cell carcinoma (LSCC). However, precise mechanism by which it promotes LSCC remains unclear. In this study, we verified high expression in tissues and cells using RT-qPCR. Analysis clinical data exhibited that was associated with a history smoking, worse T stage, lymph node metastasis, later TNM stage patients LSCC. promotion effect on proliferation, migration, invasion, tumor growth...
In the present study, molecular subtypes were determined, programmed death-ligand 1 (PD-L1) and tumor-associated immune cells (TAICs) quantitatively detected, their effect on prognosis in uterine carcinosarcoma (UCS) was analyzed. The study included 65 UCS cases. Direct sequencing of POLE exonuclease domain immunohistochemistry mismatch repair (MMR) deficiency proteins p53 used to stratify subtypes. QuPath for quantitative immunohistochemical detection PD-L1 TAICs. chi square test determine...
To confirm whether the pathological response of lymph node metastasis (LNM) to neoadjuvant chemotherapy (NCT) can predict prognosis patients with gastric cancer (GC).
C14orf159, a new protein, has been identified recently. But its expression in tissues and clinicopathologic correlation is still unknown.We carried out immunohistochemistry staining 144 gastric cancer cases this study. Then Western blot was used to detect the of protein. MTT matrigel invasion assay were assess biological effects.The immunohistochemical results indicated that C14orf159 normal mucosa close tissue remarkably higher than stomach carcinoma samples (63.9% 34.7%, respectively,...
<title>Abstract</title> The molecular changes in soft tissue sarcomas are complex. It has numerous fusion partners, and different partner diseases exhibit histological morphologies biological behaviors. A 53-year-old female patient had sarcoma the left thigh. Imaging revealed a shadow intermuscular of medial thigh, suggestive malignancy. underwent thigh mass resection inguinal lymph node dissection. Pathological histology with epithelioid morphology metastasis. Immunohistochemistry showed...
Mucosal melanoma (MM) represents an uncommon form of melanoma. Primary gastrointestinal tract (GIT) is even rarer. A 70-year-old male visited the Liaoning Cancer Hospital and Institute, China, due to upper abdominal discomfort for past two months. His endoscopy revealed a prominent, 6-cm ulcerated neoplasm in gastroesophageal junction (GEJ). Lesion endoscopic biopsy showed diffusely distributed tumour cells. He underwent subtotal gastrectomy with lymph node dissection (LND). Postoperative...
Abstract Background To explore the potential therapeutic target to treat pancreatic cancers, Tspan1 was detected in human cancer tissue and ductal adenocarcinoma cells functional role of on proliferation explored mechanism investigated. Materials Methods PCC PDAC cell lines measured by qRT-PCR Western blot. knock-downed over-expressed via transfection with Tspan1-siRNA pLNCX-TSPAN1-cDNA, survival, cycle were MTT, Alamar blue Flow Cytometry assay. The mRNA protein expression assessed...
Objective To detect the expression of miR-346 in colon cancer cells and relationship with invasion metastasis, so as to provide experimental basis for predicting treating targets cancer. Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was used microRNA-346 cell lines (HCT116, COLO205, SW620) normal epithelial (NCM460). The up-regulated or down-regulated by mimic inhibitor transfected into HCT116 cells.The transfection efficiency detected qRT-PCR.The metastasis...