A5102024874- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- RNA modifications and cancer
- Circular RNAs in diseases
- CAR-T cell therapy research
- Psoriasis: Treatment and Pathogenesis
- Angiogenesis and VEGF in Cancer
- Liver physiology and pathology
- interferon and immune responses
- Extracellular vesicles in disease
- Endometriosis Research and Treatment
- Epigenetics and DNA Methylation
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Traditional Chinese Medicine Analysis
- Cervical Cancer and HPV Research
- Organ Transplantation Techniques and Outcomes
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- RNA Interference and Gene Delivery
- IL-33, ST2, and ILC Pathways
- Pelvic and Acetabular Injuries
Sichuan University
2015-2024
State Key Laboratory of Biotherapy
2011-2024
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2024
Chengdu University of Traditional Chinese Medicine
2020-2023
Detection Limit (United States)
2022
West China Second University Hospital of Sichuan University
2013-2021
West China Hospital of Sichuan University
2017-2021
Liaoning Cancer Hospital & Institute
2018-2020
China Medical University
2018-2020
Johns Hopkins Medicine
2015-2019
IL-35 downregulates Th17 cell development and suppresses certain types of autoimmune inflammation such as collagen-induced arthritis experimental uveitis. Psoriasis is thought to be initiated by abnormal interactions between cutaneous keratinocytes systemic immune cells. However, the role in psoriasis remains unclear. In this study, we assessed three well-known models: a human keratinocyte line (HaCaT), keratin 14 (K14)-vascular endothelial growth factor A (VEGF-A)-transgenic (Tg) mouse...
Abstract Interleukin‐35 ( IL ‐35), a member of the ‐12 family, functions as new anti‐inflammatory factor involved in arthritis, psoriasis, inflammatory bowel disease IBD ) and other immune diseases. Although ‐35 can significantly prevent development inflammation many diseases, there have been no early studies accounting for role recombinant protein psoriasis. In this study, we assessed therapeutic potential three well‐known mouse models: dextransulfate sodium DSS )‐induced colitis model,...
Paclitaxel (PTX) has shown pleiotropic immunologic effects on the tumor microenvironment, and nanomicelle emerged as a promising strategy for PTX delivery. However, detailed mechanisms remain to be fully elucidated. Meanwhile, immunogenic cell death (ICD) is an effective approach activate immune system. This study investigated ICD effect of how affected immune-activation ability PTX. Methods: The were identified via expression markers vaccine experiment. Tumor size overall survival in...
MicroRNAs are endogenous, non-coding RNAs of approximately 20-22 nucleotides that regulate genes expression by binding to the 3' untranslated region (UTR) targets mRNAs and play critical roles in cancer pathways.Malignant glioma is most common highly lethal central nervous system tumor for which little effective treatment available over several decades.The purpose this study was explore therapeutic potential plasmid-based microRNA-7 (miR-7) gliomas vivo.Enhancing miR-7 levels vitro could...
Abstract Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation. A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance, such as program death-1 (PD-1/PD-L1) pathway in the tumor environment. However, determinants of response anti-PD-1 monoclonal antibodies (mAbs) treatment remain incompletely understood. In murine models, PD-1 blockade alone fails induce effective...
Background/Aims: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is an ideal anti-tumor drug because it exhibits selective cytotoxicity against cancer cells. However, certain cells are resistant to TRAIL, and the potential mechanisms still unclear. The aim of this study was reduce resistance colorectal (CRC) TRAIL. Methods: Quantitative real-time PCR analysis performed detect expression microRNA-128 (miR-128) in tissues from patients with CRC cell lines. MTT assays were used...
Abstract Background Inflammatory bowel diseases (IBD) are chronic relapsing–remitting inflammatory of the gastrointestinal tract that typically categorized into two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). Although MSCs therapy has achieved encouraging outcomes in IBD therapy, objective responses limited colon fibrosis stenosis owing to complicated microenvironment CD heterogeneity quality. Here, we chose IFN-γ kynurenic acid (KYNA) overcome low response human...
In cervical cancer, one of the most common malignant tumors in women worldwide, miR-126 has been reported to exhibit decreased expression. However, its role cancer cell proliferation and drug sensitivity remained relatively unexplored. Here, we compared expression tissues (n = 20) with that normal tissue using quantitative RT-PCR. The viability Siha cells was further measured by MTT assay after transfection mimic (Siha-miR-126 mimic) or microRNA negative control (Siha-miR NC) treatment...
This study aimed to analyze the impact of microRNA-499 (miR-499) on inflammatory damage endothelial cells during coronary artery disease (CAD) via targeting PDCD4 through NF-kB/ TNF-α signaling pathway.A total 216 CAD patients (CAD group) and 90 healthy people (normal were enrolled in our study. Endothelial collected assigned into normal, OX-LDL, negative control (NC), miR-499 inhibitor, mimic, siRNA, inhibitor + siRNA groups. The qRT-PCR western blotting performed detect mRNA protein...
Abstract The basic leucine zipper ATF-like transcription factor 2 (BATF2) has been implicated in inflammatory responses and anti-tumour effects. Little, however, is known regarding its extracellular role maintaining a non-supportive cancer microenvironment. Here, we show that BATF2 inhibits glioma growth myeloid-derived suppressor cells (MDSCs) recruitment. Interestingly, vesicles (EVs) from BATF2-overexpressing cell lines (BATF2-EVs) inhibited MDSCs chemotaxis vitro. Moreover, intracellular...
Abstract Cancer and impaired tissue wound healing with ageing are closely related to the quality of life elderly population. Given increased incidence cancer population trend globally, it is very important explore how impairs spontaneous cancer. In a murine model DSS-induced acute colitis AOM/DSS-induced colitis-associated (CAC), we found significantly decreases intestinal simultaneous CAC initiation, although does not affect AOM-induced, sporadic non-inflammatory CRC. Mechanistically,...
Abstract Background Although the whole tumor cell vaccine can provide best source of immunizing antigens, there is still a limitation that most tumors are not naturally immunogenic. Tumor cells genetically modified to secrete immune activating cytokines have been proved be more IL-18 could augment proliferation T and cytotoxicity NK cells. GM-CSF stimulate dendritic cells, macrophages enhance presentation antigens. In our study, we used mouse combined with modify Lewis lung cancer LL/2, then...
Background: Andrographolide (Andro) is an active compound extracted from Andrographis, which has protective anti-inflammatory effects. But, its pathological role in coronary heart disease (CHD) unclear, the aim of this study to investigate therapeutic effect Andro CHD and explore potential mechanism. Methods: Here, we established a mouse model CHD, rats were randomly divided into 5 groups (n=10): sham, (50 mg/kg), + (10 mg/kg). HE staining was employed evaluate changes myocardial injury...
Long non-coding RNAs (lncRNAs) have potential applications in clinical diagnosis and targeted cancer therapies. However, the expression profile of lncRNAs colorectal (CRC) initiation is still unclear. In this study, profiles mRNAs were determined by microarray at specific tumour stages an AOM/DSS-induced primary colon model. The temporal was analysed K-means clustering. Additionally, weighted correlation network analysis (WGCNA) gene ontology performed to construct co-expression networks...
Therapeutic antibodies targeting vascular endothelial growth factor (VEGF) have become a critical regimen for tumor therapy, but the efficacy of monotherapy is usually limited by drug resistance and multiple angiogenic mechanisms. Complement proteins are becoming potential candidates cancer-targeted therapy based on their role in promoting cancer progression angiogenesis. However, antitumor abilities simultaneous VEGF complement blockade were unknown. We generated humanized soluble VEGFR-Fc...
Vascular endothelial growth factor receptor (VEGFR) or vascular (VEGF) inhibitors have shown only modest clinical activity for most tumor types when used as single agents.However, present evidence indicates that these antiangiogenic drugs can cause transient "normalization" of the vasculature, thereby improving delivery systemic chemotherapy.We examined temporal changes in function response to novel VEGFR2 inhibitor, SKLB1002.Established tumor-bearing animals were evaluated at serial time...
Abstract Background Liver fibrosis (LF) is a common pathological process characterized by the activation of hepatic stellate cells (HSCs) and accumulation extracellular matrix. Severe LF causes cirrhosis even liver failure, major cause morbidity mortality worldwide. Transplantation human placental mesenchymal stem (hPMSCs) has been considered as an alternative therapy. However, underlying mechanisms appropriate time window for hPMSC transplantation are not well understood. Methods We...