A5100630086- TGF-β signaling in diseases
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Immune Response and Inflammation
- Aquaculture Nutrition and Growth
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Chemokine receptors and signaling
- Electrocatalysts for Energy Conversion
- RNA modifications and cancer
- Natural Language Processing Techniques
- Topic Modeling
- Cell death mechanisms and regulation
- Click Chemistry and Applications
- Electrochemical Analysis and Applications
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Advanced battery technologies research
- Cancer Immunotherapy and Biomarkers
- Medicinal Plant Pharmacodynamics Research
- Inflammasome and immune disorders
- Synthesis and biological activity
- Gene expression and cancer classification
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
Gansu Agricultural University
2022-2025
Liaoning Cancer Hospital & Institute
2024-2025
China Medical University
2024-2025
Hunan Normal University
2013-2025
Yunnan Institute of Tropical Crops
2025
Shanghai Jiao Tong University
2016-2025
Dalian University of Technology
2025
Central China Normal University
2021-2025
Bristol-Myers Squibb (United States)
2015-2024
Henan University of Science and Technology
2024
Earth-abundant layered tungsten disulfide (WS2 ) is a well-known electrocatalyst for acidic hydrogen evolution, but it becomes rather sluggish alkaline or oxygen evolution due to the low-density edge sites, poor conductivity, and unfavorable water dissociation behavior. Here, an interfacial engineering strategy construct efficient bifunctional by in situ growing N-doped WS2 nanoparticles on highly conductive cobalt nitride (N-WS2 /Co3 N) concurrent reaction (HER) urea oxidation (UOR)...
Background The therapeutic efficacy of neoadjuvant immunotherapy combined with chemotherapy (Io+Chemo) is superior than alone (Chemo). However, the mechanism Io+Chemo superiority remains to be further elucidated. Methods study included 128 patients resectable stage II-III gastric cancer, in which 63 were given Io+Chemo, and 65 Chemo alone. Patients treated 2-4 cycles PD-(L)1 inhibitor (Pembrolizumab, Sintililimab or Nivolumab) S-1 oxaliplatin (SOX) capecitabine (XELOX) before surgical...
Transforming growth factor beta (TGFβ), which is implicated in metastasis to various organs breast cancer, a potential target for new antitumor drugs.To identify specific inhibitors of TGFβ receptor 1 (TGFβR1) cancer metastasis, virtual library more than 400000 different compounds was screened by molecular docking modeling and confirmed with Smad-binding element luciferase TGFβR1 kinase assays. Affymetrix GeneChip expression analysis mRNA levels real-time polymerase chain reaction were...
Affinity selection screening of macrocycle libraries derived from DNA-programmed chemistry identified XIAP BIR2 and BIR3 domain inhibitors that displace bound pro-apoptotic caspases. X-ray cocrystal structures key compounds with suggested potency-enhancing structural modifications. Optimization dimeric macrocycles similar affinity for both domains were potent agents in cancer cell lines efficacious shrinking tumors a mouse xenograft model.
In recent years, the first generation of β-secretase (BACE1) inhibitors advanced into clinical development for treatment Alzheimer's disease (AD). However, alignment drug-like properties and selectivity remains a major challenge. Herein, we describe discovery novel class potent, low clearance, CNS penetrant BACE1 represented by thioamidine 5. Further profiling suggested that high fraction metabolism (>95%) was due to CYP2D6, increasing potential risk victim-based drug-drug interactions (DDI)...
Ray-finned fishes (Actinopterygii) represent more than 50 % of extant vertebrates and are great evolutionary, ecologic economic significance, but they relatively underrepresented in 'omics studies. Increased availability transcriptome data for these species will allow researchers to better understand changes gene expression, carry out functional analyses. An international project known as the "Transcriptomes 1,000 Fishes" (Fish-T1K) has been established generate RNA-seq sequences diverse...
To explore the pharmacokinetic properties of icariin (ICA) and icariside II (ICA II) following intragastric intravenous administration in rats, a rapid sensitive method by using ultra-performance liquid chromatography–tandem mass spectroscopy (UPLC-MS/MS) was developed validated for simultaneous quantification ICA rat plasma. The performed multiple reaction monitoring transitions m/z 677.1/531.1 ICA, 515.1/369.1 463.1/301.1 diosmetin-7-O-β-d-glucopyranoside (IS). assay showed linearity over...
The mechanism of Fe(2+)-initiated lipid peroxidation in a liposomal system was studied. It found that second addition ferrous ions within the latent period lengthened time lag before started. apparent depended on total dose Fe(2+) whenever added, which indicates has dual function: to initiate one hand and suppress species responsible for initiation other. When pre-existing peroxides (LOOH) were removed by incorporating triphenylphosphine into liposomes, could no longer acceleration oxidation...
TGFBR1*6A is a common hypomorphic variant of transforming growth factor beta receptor 1 (TGFBR1). associated with an increased cancer risk, but the association this polymorphism osteosarcoma remains unknown. We have measured frequency variants in cases and controls.Our case-control study based on 168 patients age- gender-matched controls. Blood samples were obtained determined by PCR amplification DNA sequencing. The odds ratio (OR) 95% confidence interval (95% CI) for calculated...
We have designed and developed novel selective TLR7 agonists that exhibited potent receptor activity in a cell-based reporter assay.
Small molecule toll-like receptor (TLR) 7 agonists have gathered considerable interest as promising therapeutic agents for applications in cancer immunotherapy. Herein, we describe the development and optimization of a series novel TLR7 through systematic structure–activity relationship studies focusing on modification phenylpiperidine side chain. Additional refinement ADME properties culminated discovery compound 14, which displayed nanomolar reporter assay activity favorable drug-like...
Background Although prognostic models based on pyroptosis-related genes (PRGs) have been constructed in bladder cancer (BLCA), the comprehensive impact of these tumor microenvironment (TME) and immunotherapeutic response has yet to be investigated. Methods Based expression profiles 52 PRGs, we utilized unsupervised clustering algorithm identify PRGs subtypes ssGSEA quantify immune cells hallmark pathways. Moreover, screened feature distinct validated associations with infiltrations tissue...
The utility of antibody therapeutics is hampered by potential cross-reactivity with healthy tissue. Over the past decade, significant advances have been made in design activatable antibodies, which increase, or create altogether, therapeutic window a parent antibody. Of these, prodrugs (pro-antibodies) are masked antibodies that advanced most for use. They designed to reveal active, only when encountering proteases upregulated microenvironment targeted disease tissue, thereby minimizing...
The composition and content of glucosinolates were investigated in the edible parts (petioles, peel flesh) tuber mustard, bamboo shoots mustard baby by high-performance liquid chromatography to reveal association between different cooking methods their glucosinolate profiles. Eight identified from including three aliphatic glucosinolates, four indole one aromatic glucosinolate. Only six eight detected mustard. results show that distribution varied widely among tissues species. highest...
The present non-precious hydrogen-evolving electrocatalysts deliver high catalytic activity either in acidic or basic media but very few simultaneously exhibit superb efficiency and stability for hydrogen evolution reaction (HER) a wide pH range, especially pyrite-phase materials (e.g., CoS2, NiSe2), probably due to their kinetic energy barriers of initial water dissociation process. Herein, we report phase transition engineering porous NiSe2 into NiP1.86Se0.14 by heavy phosphorus doping,...
Eotetranychus sexmaculatus has long been recognized as an important spider mite pest of rubber trees. Recently, increasing damage from Oligonychus biharensis elevated its importance a key pest. These two species share highly overlapping ecological niches, with outbreaks strongly associated high temperatures and drought stresses. However, little is known regarding the potential competition between these role temperature in shaping interactions. This study investigates development reproduction...
This study aimed to identify risk factors influencing long-term treatment outcomes in patients with complex perianal fistulizing Crohn's disease (pfCD) following fistula-tract laser closure (FiLaC™). A retrospective analysis was conducted on data from pfCD who underwent FiLaC™ January 2019 December 2020, including demographics, pharmacological regimens, and preoperative MRI assessments. Follow-up monitored fistula such as healing, remission, failure, recurrence. Among 49 followed for an...
(1) Background: Bovine mastitis is a lactational disease caused by infection and milk stagnation in the mammary glands. Danggui buxue decoction (DBD), traditional remedy for blood tonification, anti-inflammation, antioxidation, has not been used previously to treat mastitis. (2) Methods: In this study, an Escherichia coli model was established infecting lactating Kunming mice with clinically isolated bovine mastitis-derived E. coli. Based on this, effects of DBD inflammation oxidative stress...
Abstract Supported metal electrocatalysts with appropriate metal‐support interactions (MSIs) show great potential for heterogeneous catalysis, however, precisely tuning the at an atomic level remains a significant challenge. In this work, single‐atom Co‐N 4 sites are introduced to tailor interfaces between PtIr alloy clusters and carbonaceous substrates, thereby establishing highly active stable catalysts toward hydrogen oxidation reaction (HOR) in alkaline electrolytes realizing atomically...
Ru-based catalysts manifest unparalleled hydrogen evolution reaction (HER) performance, but the hydrolysis of Ru species and accumulation corresponding intermediates greatly limit HER activity stability. Herein, nanoparticle assemblies modified with single Mo atoms supported on N-incorporated graphene (referred to as MoRu-NG) are compounded via hydrothermal chemical vapor deposition (CVD) methods. The incorporation into lattices modifies local atomic milieu around centers, significantly...
The ELR+CXC chemokines are multifunctional mediators that mainly responsible for the recruitment of leucocytes to sites inflammation and infection. Because their high sequence identity with mammalian IL-8, fish IL-8-like CXCs have been named as piscine 'IL-8' included in ELR+ subgroup, even though there is no reliable functional or evolutionary evidence support this classification. In investigation, a homologue from black seabream (Acanthopagrus schlegeli), called BS CXC, has cloned...
Caldicellulosiruptor bescii is the most thermophilic cellulolytic species of organisms known to date. In our previous study, GH10 xylanase CbXyn10B from C. displayed outstanding hydrolytic activity toward various xylans at high temperatures. To understand structural basis for this protein's catalysis and thermostability, we solved crystal structures its complexes with xylooligosaccharides. These models were used guide comparison mesophilic counterpart PbXyn10B. A distinctive feature that...