A5007923055- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Genomics and Chromatin Dynamics
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Ferroptosis and cancer prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Gallbladder and Bile Duct Disorders
- Metastasis and carcinoma case studies
- Renal cell carcinoma treatment
- Gastrointestinal disorders and treatments
- Hepatitis C virus research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Knee injuries and reconstruction techniques
- Orthopedic Surgery and Rehabilitation
- Appendicitis Diagnosis and Management
- Gastrointestinal Tumor Research and Treatment
- Cancer-related gene regulation
Wenzhou Medical University
2014-2025
Wenzhou City People's Hospital
2018-2024
Soochow University
2017-2022
Yueyang Hospital
2022
Shanghai University of Traditional Chinese Medicine
2022
Wannan Medical College
2021
University of California, San Diego
2015-2019
Howard Hughes Medical Institute
2015-2018
Eastern Hepatobiliary Surgery Hospital
2018
Second Military Medical University
2018
Tumors are usually refractory to anti-cancer therapeutics under hypoxic conditions. However, the underlying molecular mechanism remains be elucidated. Our study intended identify hypoxia inducible lncRNAs and their biological function in gastric cancer (GC). Differentially expressed were determined by microarray analysis between GC cells exposed (1% O2) normoxia (21% for 24 h. The expression level of CBSLR was manipulated several cell lines perform analyses both vitro vivo. We identified a...
Abstract Gastric cancer ( GC ) remains a threat to public health with high incidence and mortality worldwide. Increasing evidence demonstrates that long non‐coding RNAs (lncRNAs) play critical regulatory roles in biology, including . Previous profiling study showed lnc RNA linc00261 was aberrantly expressed However, the role of progression precise molecular mechanism remain unknown. In this study, we report significantly down‐regulated tissues expression level negatively correlated advanced...
Ferroptosis, a unique form of nonapoptotic-regulated cell death caused by overwhelming lipid peroxidation, represents an emerging tumor suppression mechanism. Growing evidence has demonstrated that metabolism plays important role in the regulation ferroptosis. Specifically, association between methionine and ferroptosis remains undefined.We performed vitro vivo experiments to evaluate influence on sensitivity. Pharmacological genetic blockade cycle was utilized relevant molecular analyses...
Background Research indicates that the ratio of fasting blood glucose (FBG) to serum high-density lipoprotein cholesterol (HDL-C) (GHR) can accurately predict many diseases. Nevertheless, relationship between GHR and risk gallbladder stones remains unclear. This study investigates possible incidence stones. Methods research used information gathered from National Health Nutrition Examination Survey (NHANES) March 2017 2020. A calculation was made determine by dividing level HDL-C level....
The activation of tumor-associated macrophages (TAMs) facilitates the progression gastric cancer (GC). Cell metabolism reprogramming has been shown to play a vital role in polarization TAMs. However, methionine function TAMs remains be explored.Monocytes/macrophages were isolated from peripheral blood, tumor tissues or normal healthy donors patients with GC. was evaluated both vivo analyses and vitro experiments. Pharmacological inhibition cycle modulation key metabolic genes employed, where...
Long noncoding RNAs (lncRNAs) have been demonstrated to play a role in carcinogenesis, but their mechanisms of function remain elusive. We explored the oncogenic GCAWKR gastric cancer (GC) using human tissues and cell lines. The situ hybridization analysis was utilized determine levels samples from 42 GC patients real-time qPCR 123 patients. were modulated lines, relevant biological molecular analyses performed. Levels upregulated compared with normal associated tumor size, lymph node...
The complement system acts as an integral part of the innate immune response, which primarily to remove pathogens and injured cells. Emerging evidence has shown activation regulatory function complements in tumor microenvironment (TME). We revealed expression levels various human cancers their role prognosis infiltration.The differential was explored via Tumor Immune Estimation Resource (TIMER) site Oncomine database. To investigate whether these differentially expressed have correlation...
Standards in treatment of acute cholecystitis (AC) the elderly and high-risk patients has not been established. Our study evaluated efficacy safety B-mode ultrasound-guided percutaneous transhepatic gallbladder drainage (PTGD) combination with laparoscopic cholecystectomy (LC) for patients.Our enrolled 35 AC patients, hospitalized between January 2010 April 2014 at Wenzhou People's Hospital. The underwent PTGD LC (PTGD + group). As controls, a separate group who alone (LC group) during same...
Multiport robots are now widely used for total gastrectomy gastric cancer, while there is almost a void of research on whether single-port (SP) can be gastrectomy. Here, we report case 75-year-old female patient who was diagnosed with cardia adenocarcinoma by gastroscopy and underwent assisted the SHURUI SP robot. We successfully accomplished D2 lymph node dissection using novel robotic platform. The discharged from hospital no complications during or after surgery. Pathologic diagnosis...
Background The systemic inflammation score (SIS), as calculated from preoperative serum albumin level and lymphocyte‐to‐monocyte ratio, has been demonstrated to be a prognostic marker in cancer. present study intended investigate the role of SIS gastric cancer patients after curative gastrectomy comparison with other markers. Methods Preoperative was retrospectively who underwent between 2007 2011 Fudan University Shanghai Cancer Center. accuracy each compared utilizing time‐dependent...