A5025912180- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phagocytosis and Immune Regulation
- Cytokine Signaling Pathways and Interactions
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Advanced Glycation End Products research
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- interferon and immune responses
- Immune Response and Inflammation
- Lung Cancer Treatments and Mutations
- Cell Adhesion Molecules Research
- Mycobacterium research and diagnosis
- Cancer, Hypoxia, and Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Ferroptosis and cancer prognosis
- Wnt/β-catenin signaling in development and cancer
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Medical and Biological Ozone Research
Henan Cancer Hospital
2024
Zhengzhou University
2024
First Affiliated Hospital of Zhengzhou University
2018-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2022
<h3>Background</h3> Chemotherapy combined with immunotherapy becomes the main trend in lung cancer intervention; however, how chemotherapy promotes immune function remains elusive. Therefore, we sought to determine function. <h3>Methods</h3> We determined 100 NSCLC patients expression of CD8, functional markers (IFN-γ, Granzyme B, and Perforin) specific chemokines by quantitative real-time reverse transcriptase-PCR. Functional experiments were carried out check whether docetaxel (DOC), a...
Abstract IFNγ is conventionally recognized as an inflammatory cytokine that plays a central role in antitumor immunity. Although it has been used clinically to treat variety of malignancies, low levels the tumor microenvironment (TME) increase risk metastasis during immunotherapy. Accumulating evidence suggests can induce cancer progression, yet mechanisms underlying controversial development remain unclear. Here, we reveal dose-dependent effect inducing stemness accelerate progression...
Abstract Neutrophil extracellular traps (NET), formed by the release of decondensed chromatin and granules, have been shown to promote tumor progression metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone NET formation, highlighting need for a more comprehensive understanding mechanisms action NETs liver cancer. Here, we showed that DNA (NET-DNA) binds transmembrane coiled-coil domains 6 (TMCO6) on CD8+ T cells impair antitumor immunity thereby HCC...
Abstract Background High probability of metastasis limited the long-term survival patients with hepatocellular carcinoma (HCC). Our previous study revealed that Galectin-3 was closely associated poor prognosis in HCC patients. Methods The effects on tumour were investigated vitro and vivo, underlying biological molecular mechanisms involved this process evaluated. Results showed a close correlation vascular invasion large-scale from multiple sets. significantly diverse metastasis-related...
The abnormal expression of noncoding RNAs has attracted increasing interest in the field hepatocellular carcinoma progression. However, underlying molecular mechanisms mediated by these processes are unclear. Here, we obtained profiles long RNAs, microRNAs, and mRNAs from Gene Expression Omnibus database identified hepatocarcinogenesis-specific differentially expressed transcripts. Next, significant Ontology pathway terms that transcripts involved in. Using functional analysis target...
Abstract High-mobility group protein B1 (HMGB1) is a danger signaling molecule that has been found to trigger an effective antitumor immune response. However, the mechanisms underlying its effects are not fully understood. Here, we HMGB1 release induced by chemotherapy in patients with non–small cell lung cancer was negatively correlated PD-1 expression on CD8+ T cells. In vitro analysis indicated treatment led significant decrease level of Further demonstrated reduced inducing...
Aflatoxin exposure increases the risk for hepatocellular carcinoma (HCC) in hepatitis B virus (HBV)-infected individuals, particularly males. We investigated sex-based differences HCC genome and antitumor immunity.Whole-genome, whole-exome, RNA sequencing were performed on 101 patient samples (47 males, 54 females) that resulted from HBV infection aflatoxin Qidong. Androgen expression of metabolism-related genes nonhomologous DNA end joining (NHEJ) factors examined HBV-positive cell lines,...
Therapies targeting programmed cell death protein 1 (PD-1) have gained great success in patients with multiple types of cancer. The regulatory mechanisms underlying PD-1 expression been extensively explored. However, the impact long noncoding RNAs on remains elusive. In this study, we identified Notch1/lncNDEPD1 axis, which plays a critical role human CD8+ T cells. RNA sequencing and quantitative reverse transcription PCR data showed that lncNDEPD1 was upregulated activated cells, especially...
Abstract Interferon-γ (IFN-γ) is conventionally recognized as an inflammatory cytokine that play a central role in antitumor immunity. Clinically, although has been used clinically to treat variety of malignancies, low-level IFN-γ the tumor microenvironment (TME) increases risk metastasis during immunotherapy. Accumulating evidence suggested can induce cancer progression. The mechanisms underlying controversial regulating development remain unclear. Herein, we firstly revealed dose-dependent...
<div>Abstract<p>Neutrophil extracellular traps (NET), formed by the release of decondensed chromatin and granules, have been shown to promote tumor progression metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone NET formation, highlighting need for a more comprehensive understanding mechanisms action NETs liver cancer. Here, we showed that DNA (NET-DNA) binds transmembrane coiled-coil domains 6 (TMCO6) on CD8<sup>+</sup> T cells impair...
<div>Abstract<p>Neutrophil extracellular traps (NET), formed by the release of decondensed chromatin and granules, have been shown to promote tumor progression metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone NET formation, highlighting need for a more comprehensive understanding mechanisms action NETs liver cancer. Here, we showed that DNA (NET-DNA) binds transmembrane coiled-coil domains 6 (TMCO6) on CD8<sup>+</sup> T cells impair...
<p>The effects of tumor-derived TGF-β1 on NET formation.</p>
<p>The representative dotplots used for gating strategies of flow staining CD8+ T cells in in-vivo experiments.</p>
<p>Association of NET expression with clinicopathological features in patients HCC.</p>
<p>Association of NET expression with clinicopathological features in patients HCC.</p>
<p>Pancancer analysis for the expression and prognosis value of TMCO6 in multiple cancer types.</p>
<p>The effects of tumor-derived TGF-β1 on NET formation.</p>
<p>Receiver operating characteristic curves analysis for NETs in HCC.</p>
<p>The representative dotplots used for gating strategies of flow staining NK, CD4+, CD8+ IFN-γ+, and granzyme B+ cells in in-vivo experiments.</p>
<p>Methods for Neutrophil isolation and culture, CD8+ T-cell Tumor-infiltrating lymphocyte isolation, Cell membrane protein NET-DNA purification biotin-labeling so on.</p>
<p>The expression and prognosis value of NETs in HB.</p>
<p>The expression of TMCO6 in HCC tissues and its role cell behaviors.</p>
<p>The expression of TMCO6 in HCC tissues and its role cell behaviors.</p>
<p>The expression of TMCO6 and its relationship with CD8+ T cell-immunity in HB.</p>