A5100390870- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Research and Splicing
- Systemic Lupus Erythematosus Research
- Endometrial and Cervical Cancer Treatments
- Lipid metabolism and disorders
- Invertebrate Immune Response Mechanisms
- Railway Engineering and Dynamics
- Railway Systems and Energy Efficiency
- Electrical Contact Performance and Analysis
- Autophagy in Disease and Therapy
- Extracellular vesicles in disease
- Pregnancy and preeclampsia studies
- Immune Response and Inflammation
- Technology Adoption and User Behaviour
- Cholesterol and Lipid Metabolism
- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Adversarial Robustness in Machine Learning
- Sensorless Control of Electric Motors
- Ferroptosis and cancer prognosis
- Protein Hydrolysis and Bioactive Peptides
- RNA regulation and disease
Gansu Agricultural University
2022-2025
Nanjing Drum Tower Hospital
2022-2025
South China Normal University
2022-2025
Shandong Provincial Hospital
2024
Shandong University
2024
Nanjing University
2024
Qilu Hospital of Shandong University
2023
Northwest Women's and Children's Hospital
2023
Xi'an Jiaotong University
2023
Hebei University
2023
Acute myocardial infarction (AMI) is one of the leading causes death in world. However, specific diagnostic biomarkers have not been fully determined, and candidate regulatory targets for AMI identified to date. Long noncoding RNAs (lncRNAs) are a class RNA molecules that diverse functions during embryonic development, normal life, disease higher organisms. research on role lncRNAs cardiovascular diseases, particularly AMI, still its infancy. HOX antisense intergenic (HOTAIR), 2.2 kb lncRNA,...
Astrocyte-microglial interaction plays a crucial role in brain injury-associated neuroinflammation. Our previous data illustrated that astrocytes secrete microRNA, leading to anti-inflammatory effects on microglia. Long non-coding RNAs participate neuroinflammation regulation after traumatic injury. However, the effect of microglial phenotype via long and underlying molecular mechanisms remain elusive. We used RNA sequencing murine found exosomal 4933431K23Rik attenuated injury-induced...
Osteoarthritis (OA) is the most common degenerative joint disease, and its main pathological mechanism articular cartilage degeneration. The purpose of this study was to investigate role mitophagy in pathogenesis chondrocyte ferroptosis OA. expressions related proteins (GPX4, FTH1, COX2) ubiquitin-dependent (PARKIN, PINK1) intact injured areas OA were analyzed. Nitro oxide JP4-039, a mitochondrial targeting antioxidant, has bifunctional mitochondria. Then we evaluated potential protective...
Abstract Long non‐coding RNAs (lncRNAs) have shown critical roles in multiple cancers via competitively binding common microRNAs. miR‐214 has been proved to play tumour suppressive various cancers, including cervical cancer. In this study, we identified that lncRNA LINC01535 physically binds miR‐214, relieves the repressive of on its target EZH2, and therefore up‐regulates EZH2 protein expression. Intriguingly, also found directly represses expression . Thus, form double negative regulatory...
Hepatocellular carcinoma (HCC) is one of the major malignancies and second most common cause cancer-related death worldwide. Sorafenib, an approved first-line systematic treatment agent for HCC, capable to effectively improve survival patients with advanced HCC. The long-noncoding RNA (lncRNA) differentiation antagonizing non-protein coding (DANCR) has been reported exert oncogenic functions in several kinds human cancers. However, role lncRNA DANCR sorafenib resistance HCC remains...
Background: There is mounting evidence that microRNAs play an important role in nasopharyngeal carcinoma, which widely prevalent South China and the most metastatic cancer among head neck cancers. Recently, it has been shown miR-494 involved progression prognosis of carcinoma. However, little known about function mechanism miR-494-3p In present study, we aimed to investigate effects on migration invasion carcinoma further explore underlying mechanisms these processes. Methods: The expression...
The abnormal expression of noncoding RNAs has attracted increasing interest in the field hepatocellular carcinoma progression. However, underlying molecular mechanisms mediated by these processes are unclear. Here, we obtained profiles long RNAs, microRNAs, and mRNAs from Gene Expression Omnibus database identified hepatocarcinogenesis-specific differentially expressed transcripts. Next, significant Ontology pathway terms that transcripts involved in. Using functional analysis target...
Tetranychus urticae (Acari: Tetranychidae) is a widely distributed agricultural pest, and it possesses an exceptional capacity to withstand or adapt short-term heat stress. To investigate the molecular mechanisms underlying this tolerance, using both transcriptome whole-genome data, we identified six distinct POD genes in T. characterized their physicochemical properties structural features. Real-time quantitative PCR (RT-qPCR) was utilized analyze expression profiles of these under Our...
Pulmonary fibrosis is an excessive repair response to tissue damage, triggering hyperplasia of fibrotic connective tissues; however, there no effective treatment in a clinical setting. The purpose the present study was investigate roles long non‑coding RNA nuclear enriched abundant transcript 1 (NEAT1) and microRNA‑455‑3p (miR‑455‑3p) were investigated pulmonary fibrosis. In this study, mRNA expression levels NEAT1, miR‑455‑3p SMAD3 HPAEpiC alveolar BEAS‑2B bronchial epithelial cell lines...
MicroRNAs (miRNAs) are a class of small non-coding RNAs that have been shown to play important post-transcriptional regulatory roles in the growth and development skeletal muscle tissues. However, limited research into effect miRNAs on goats has reported. In this study, Liaoning cashmere (LC) Ziwuling black (ZB) with significant phenotype difference meat production performance were selected Longissimus dorsi tissue expression profile between two goat breeds was then compared using RNA...
BACKGROUND: Many studies have demonstrated that the long non-coding RNA (lncRNA), NEAT1_1, plays critical roles in various human tumor entities and is related to survival of patients with malignancies. However, role NEAT1_1 diffuse large B cell lymphoma (DLBCL) remains unclear. The ai m this study was investigate DLBCL. METHODS: expression evaluated paraffin-embedded tissues from 64 DLBCL 15 lymphnoditis using ISH method. correlations between levels clinical-pathological features patients'...
Studies of the gene and miRNA expression profiles associated with postnatal late growth, development, aging skeletal muscle are lacking in sika deer. To understand molecular mechanisms growth development deer muscle, we used de novo RNA sequencing (RNA-seq) microRNA (miRNA-seq) analyses to determine differentially expressed (DE) unigenes miRNAs from tissues at 1, 3, 5, 10 years A total 51,716 unigenes, 171 known miRNAs, 60 novel were identified based on four mRNA small libraries. 2,044 11...
Accumulating evidences have revealed the dysregulated expressions and critical roles of non-coding RNAs in various malignancies, including cervical cancer. Nevertheless, our knowledge about vast majority is still lacking. Here we identified long RNA (lncRNA) SPINT1-AS1 as a novel cancer-associated lncRNA. was increased cancer correlated with advanced stage poor prognosis. direct downstream target miR-214, well-known tumor suppressive microRNA (miRNA) Intriguingly, also found to repress...
Allergic rhinitis (AR) is a complex disorder with variable pathogenesis. Increasing evidence suggests that the LRRC8A involved in maintaining cellular stability, regulating immune cell activation and function, playing significant roles inflammation. However, involvement of AR inflammation its underlying mechanisms remain unclear. expression patients, confirmed by qRT-PCR Western blotting, was analyzed to investigate relationship clinical characteristics patients. In vitro, IL-13 stimulated...
<b><i>Introduction:</i></b> Follicular thyroid carcinoma (FTC) is more aggressive than the most common papillary (PTC). However, current research on FTC less PTC. Here, we investigated effects of long noncoding RNA (lncRNA) GAS5 and miR-221-3p in FTC. <b><i>Methods:</i></b> Quantitative real-time polymerase chain reaction (qRT-PCR) was employed to detect expression tissues cells. Cell proliferation assessed by CCK8 EdU assays. Flow cytometry...
Milk fat is the foremost nutrient of milk and a vital indicator in evaluating quality. Accumulating evidence suggests that microRNAs (miRNAs) are involved synthesis fat. The miR-200c closely related to lipid metabolism, but little known about its effect on MECs ewes. Herein, proliferation ovine mammary epithelial cells (MECs) target relationship with predicted gene were investigated. regulatory effects expression genes content triglycerides further analyzed. results revealed level was...