A5041762312- Plant Stress Responses and Tolerance
- Plant Molecular Biology Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- GABA and Rice Research
- Plant nutrient uptake and metabolism
- Photosynthetic Processes and Mechanisms
- Fractal and DNA sequence analysis
- Seed Germination and Physiology
- Machine Learning in Bioinformatics
- Plant Gene Expression Analysis
- Plant tissue culture and regeneration
- Rice Cultivation and Yield Improvement
- RNA and protein synthesis mechanisms
- Plant responses to water stress
- Circular RNAs in diseases
- Aluminum toxicity and tolerance in plants and animals
- Heavy metals in environment
- Computational Drug Discovery Methods
- Food composition and properties
- Plant Reproductive Biology
- Postharvest Quality and Shelf Life Management
- Plant Surface Properties and Treatments
- CRISPR and Genetic Engineering
- Horticultural and Viticultural Research
Hunan Agricultural University
2013-2025
University of Illinois Urbana-Champaign
2025
Yueyang Changling Equipment Research Institute (China)
2025
Affiliated Hospital of Qingdao University
2024
Sichuan Agricultural University
2022-2024
Shijiazhuang University
2024
Qingdao University
2024
China National Hybrid Rice R&D Central Hunan Hybrid Rice Reserch Center
2016-2023
State Key Laboratory of Hybrid Rice
2016-2023
Institute of Crop Sciences
2023
Rice grain with excessive cadmium (Cd) is a major source of dietary Cd intake and serious threat to health for people who consume rice as staple food. The development elite cultivars consistently low content challenging conventional breeding approaches, new strategies urgently need be developed. Here, we report the indica lines accumulation no transgenes by knocking out metal transporter gene OsNramp5 using CRISPR/Cas9 system. Hydroponic culture showed that concentrations in shoots roots...
Quickly and precisely gain genetically enhanced breeding elites with value-adding performance traits is desired by the crop breeders all time. The present of gene editing technologies, especially CRISPR/Cas9 system capacities efficiency, versatility multiplexing provides a reasonable expectation towards goals. For exploiting possible application to accelerate speed process at technology, in this study, Agrobacterium tumefaciens-mediated transformation method was used for obtaining tomato ALC...
Rice at reproductive stage is more sensitive to environmental changes, and little known about the mechanism of heat response in rice panicle. Here, using microarray, we provided a time course gene expression profile panicle anther developmental 8 after 40°C treatment for 0 min, 20 60 2 h, 4 h. The identified differentially expressed genes were mainly involved transcriptional regulation, transport, cellular homeostasis, stress response. predominant transcription factor families responsive...
OsNRAMP5 is a transporter responsible for cadmium (Cd) and manganese (Mn) uptake root-to-shoot translocation of Mn in rice plants. Knockout regarded as an effective approach to minimize Cd accumulation rice. It vital evaluate the effects knocking out on accumulation, well tolerance plants response varying environmental concentrations, uncover underlying mechanism, which until now, has remained largely unexplored. This study showed that knockout decreased uptake, but simultaneously...
Abstract Gestational diabetes mellitus (GDM) is known as different degree glucose intolerance that initially identified during pregnancy. MicroRNAs (miRs) may be a potential candidate for treatment of GDM. Herein, we suggested miR‐351 could an inhibitor in the progression GDM via phosphoinositide 3‐kinase/protein kinase B (PI3K/AKT) pathway. Microarray analysis was used to identify differentially expressed genes and predict miRs regulating flotillin 2 (FLOT2). Target relationship between...
Rheumatoid arthritis (RA) is a chronic systemic auto- immune disease characterized by joint synovitis. Recent evidence suggests that rheumatoid synovial fibroblasts (RASFs) promote destruction. In this study, we investigated the role of microRNA-26b (miR-26b) in cell proliferation and inflammatory cytokine secretion using patient-derived fibroblast-like synoviocyte (RAFLS) to understand pathways influencing arthritis.RAFLS were cultured vitro transfected with miR-26b mimics (experimental...
Pancreatic cancer is one of the most deadly cancers with a poor prognosis. Although microRNAs are involving in carcinogenesis and development pancreatic cancer, little information known regarding role miR-663b cancer. In this study, expression cells was down-regulated by hypermethylation its putative promoter region, overexpression repressed cell proliferation, invasion migration, induced apoptosis cells. Bioinformatics analysis, luciferase report assay rescue experiments showed that...
Cuticular wax covers aerial organs of plants and functions as the outermost barrier against non-stomatal water loss. We reported here functional characterization Glossy1(GL1)-homologous gene OsGL1-3 in rice using overexpression RNAi transgenic plants. was ubiquitously expressed at different level except root its expression up-regulated under ABA PEG treatments. The transient OsGL1-3–GFP fusion protein indicated that is mainly localized plasma membrane. Compared to wild type, exhibited...
Salt stress has the most severe impact on plant growth and development, including seed germination. However, little is known about mechanism of NR (nitrate reductase)-associated nitric oxide (NO) regulates salt tolerance during germination in rice. Herein, we shown that inhibition by was significantly impaired sodium nitroferricyanide (SNP), a NO donor. Then triple mutant, nr1/nr2/nr3, generated. Results mutants were delayed much more sensitive to than WT plant, which can be rescued...
Heat shock transcription factors (HSF) are divided into classes A, B and C. Class A generally recognized as transcriptional activators, while functional characterization of class C heat have not been fully developed in most plant species. We isolated characterized a novel HSF factor gene, TrHSFB2a (a HSF) from the drought stress-sensitive forage crop species, white clover (Trifolium repens). was highly homologous to MtHSFB2b, CarHSFB2a, AtHSFB2b AtHSFB2a. The expression strongly induced by...
Background: There is mounting evidence that microRNAs play an important role in nasopharyngeal carcinoma, which widely prevalent South China and the most metastatic cancer among head neck cancers. Recently, it has been shown miR-494 involved progression prognosis of carcinoma. However, little known about function mechanism miR-494-3p In present study, we aimed to investigate effects on migration invasion carcinoma further explore underlying mechanisms these processes. Methods: The expression...
Low-temperature germination (LTG) is an important agronomic trait for direct-seeding cultivation of rice (Oryza sativa). Both OsMYB30 and OsTPP1 regulate the cold stress response in rice, but function regulating LTG underlying molecular mechanism remains unknown. Employing transcriptomics functional studies revealed a sugar signaling pathway that regulates seed to low temperature (LT). Expression was induced by LT during germination, overexpressing either or delayed increased sensitivity...
Abstract Soil salinity is a destructive environmental factor that inhibits plant growth and crop yield. Applying nitrogen fertilizer practical method to enhance salt tolerance. However, the underlying mechanisms remain largely unknown. Here, we demonstrated NO3−-enhanced tolerance in rice (Oryza sativa L.) seedlings mediated by nitrate reductase (NR)-dependent nitric oxide (NO) production. Seedlings grown condition (N) exhibited much greater compared those ammonium (AN) (A) conditions,...
Detecting Coenzyme A (CoA) in cells is vital for understanding its role metabolism. DNA aptamers, though widely used monitoring many other molecules, have not been effective CoA...