A5030083006- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Phagocytosis and Immune Regulation
- Fungal Biology and Applications
- Nanoplatforms for cancer theranostics
- Medicinal plant effects and applications
- Genetics, Aging, and Longevity in Model Organisms
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Complementary and Alternative Medicine Studies
- Advanced Glycation End Products research
- Medicinal Plants and Bioactive Compounds
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Animal Nutrition and Physiology
- Vascular Tumors and Angiosarcomas
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Endoplasmic Reticulum Stress and Disease
- Alcohol Consumption and Health Effects
- Immune Cell Function and Interaction
- Natural Antidiabetic Agents Studies
- Cardiac tumors and thrombi
- Lung Cancer Research Studies
- Sesquiterpenes and Asteraceae Studies
- Peroxisome Proliferator-Activated Receptors
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Stanford University
2017
Stanford Cancer Institute
2014
Cancer Prevention Institute of California
2014
Abstract Neutrophil extracellular traps (NET), formed by the release of decondensed chromatin and granules, have been shown to promote tumor progression metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone NET formation, highlighting need for a more comprehensive understanding mechanisms action NETs liver cancer. Here, we showed that DNA (NET-DNA) binds transmembrane coiled-coil domains 6 (TMCO6) on CD8+ T cells impair antitumor immunity thereby HCC...
Chemoresistant cancer cells express high levels of aldehyde dehydrogenases (ALDHs), particularly in head and neck squamous cell carcinoma (HNSCC). The ALDH family enzymes detoxify both exogenous endogenous aldehydes. Since many chemotherapeutic agents, such as cisplatin, result the generation cytotoxic aldehydes oxidative stress, we hypothesized that expressing may be more chemoresistant due to their increased detoxifying capacity inhibitors ALDHs sensitize them these drugs. Here, show...
The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes oxidative stress, chemoresistant cancer cells express high levels of ALDH enzymes, we hypothesized that different expression within may show chemosensitivity. ALDH2 has the lowest Km for acetaldehyde among isozymes acetaldehydes in addition to other reactive aldehydes, 4-hydroxy-nonenal, malondialdehyde...
Vasculogenic mimicry (VM) induced by Epstein-Barr virus (EBV) infection plays an important role in resistance to anti-vascular endothelial growth factor (VEGF) therapy EBV-associated epithelial cancers; however, the interaction between VM and immune microenvironment has not been systematically investigated.
Cordyceps sinensis Cs‐5, a mycelia fermentation product of (Cs), has shown its health benefits in modulating immune functions and enhancing sexual functions. This study was to examine the effects Cs‐5 on improving memory learning abilities mouse model with impairment. ICR male mice (2 months) were randomized into 3 groups basis pre‐study swimming latency water maze test, received at dose 0.5 or 1.5 g/kg, vehicle for 60 days. The intraperitoneal injection Scopolamine Hydrobromide 5mg/kg...
Ganoderma lucidum (Reishi) is traditionally used as a medicinal herb in China for immune enhancement, cancer prevention and adjuvant therapy. We reported that ReishiMax (RM) with enrichment of Reishi triterpenes polysaccharides extends the lifespan mice (FASEB J 2012, 26:373.2). further studied molecular mechanisms RM’s anti‐aging effect aged mice. Aging‐induced changes gene pathway expressions (GE) were tested via microarray on liver, spleen, muscle neocortex from young (5 mo), old (25 mo)...
<div>Abstract<p>Neutrophil extracellular traps (NET), formed by the release of decondensed chromatin and granules, have been shown to promote tumor progression metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone NET formation, highlighting need for a more comprehensive understanding mechanisms action NETs liver cancer. Here, we showed that DNA (NET-DNA) binds transmembrane coiled-coil domains 6 (TMCO6) on CD8<sup>+</sup> T cells impair...
<div>Abstract<p>Neutrophil extracellular traps (NET), formed by the release of decondensed chromatin and granules, have been shown to promote tumor progression metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone NET formation, highlighting need for a more comprehensive understanding mechanisms action NETs liver cancer. Here, we showed that DNA (NET-DNA) binds transmembrane coiled-coil domains 6 (TMCO6) on CD8<sup>+</sup> T cells impair...
<p>The effects of tumor-derived TGF-β1 on NET formation.</p>
<p>The representative dotplots used for gating strategies of flow staining CD8+ T cells in in-vivo experiments.</p>
<p>Association of NET expression with clinicopathological features in patients HCC.</p>
<p>Association of NET expression with clinicopathological features in patients HCC.</p>
<p>Pancancer analysis for the expression and prognosis value of TMCO6 in multiple cancer types.</p>
<p>The effects of tumor-derived TGF-β1 on NET formation.</p>
<p>Receiver operating characteristic curves analysis for NETs in HCC.</p>
<p>The representative dotplots used for gating strategies of flow staining NK, CD4+, CD8+ IFN-γ+, and granzyme B+ cells in in-vivo experiments.</p>
<p>Methods for Neutrophil isolation and culture, CD8+ T-cell Tumor-infiltrating lymphocyte isolation, Cell membrane protein NET-DNA purification biotin-labeling so on.</p>
<p>The expression and prognosis value of NETs in HB.</p>
<p>The expression of TMCO6 in HCC tissues and its role cell behaviors.</p>
<p>The expression of TMCO6 in HCC tissues and its role cell behaviors.</p>
<p>The expression of TMCO6 and its relationship with CD8+ T cell-immunity in HB.</p>
<p>TGF-β1-signaling inhibition or TMCO6 deficiency combined with anti-PD-1 abolishes NET-driven HCC progression in vivo.</p>
<p>NET-DNA regulates CD8+ T cell-immunity via TMCO6.</p>
<p>The prognostic value of TMCO6 in HB and its role cell behaviors.</p>