A5010808794- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Oral health in cancer treatment
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Colorectal and Anal Carcinomas
- Salivary Gland Tumors Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Nutrition and Health in Aging
- Head and Neck Surgical Oncology
- Advanced Radiotherapy Techniques
- Cancer survivorship and care
- Bacteriophages and microbial interactions
- NF-κB Signaling Pathways
- Cell death mechanisms and regulation
- Nuclear Structure and Function
- Diagnosis and Treatment of Venous Diseases
- Laser Applications in Dentistry and Medicine
- Mitochondrial Function and Pathology
- Digital Imaging in Medicine
Linköping University
2015-2025
Region Östergötland
2019-2024
Industrial Development Center (Sweden)
2024
Oncology Specialists of Charlotte
2023
Örebro University Hospital
2021
Stanford University
2014-2017
Linköping University Hospital
2007-2017
Helsinki University Hospital
2016
University of Helsinki
2016
Finnish Cancer Registry
2016
Head and Neck Squamous Cell Carcinoma (HNSCC) tumors are often resistant to therapies. Therefore searching for predictive markers new targets treatment in clinically relevant vitro tumor models is essential. Five HNSCC-derived cell lines were used assess the effect of 3D culturing compared 2D monolayers terms proliferation, response anti-cancer therapy as well expression EMT CSC genes. The viability proliferation capacity HNSCC cells induction apoptosis spheroids after was assessed by MTT...
// Oihana Murillo-Sauca 1,5,6 , Man Ki Chung June Ho Shin Christina Karamboulas 7 Shirley Kwok 4 Young Jung Richard Oakley 1,5 James R. Tysome Lovisa O. Farnebo Michael J. Kaplan Davud Sirjani Vasu Divi F. Christopher Holsinger Chafeek Tomeh Anthony Nichols 8 Quynh T. Le 2,5 A. Dimitrios Colevas 3,5 S. Kong 4,5 Ravindra Uppaluri 9 Lewis Jr. 9,10 Laurie E. Ailles and John B. Sunwoo 1 Division of Head Neck Surgery, Department Otolaryngology, Stanford University School Medicine, Stanford, CA 2...
We previously identified WRAP53 as an antisense transcript that regulates the p53 tumor suppressor. The gene also encodes a protein essential for Cajal body formation and involved in cellular trafficking of survival motor neuron complex, telomerase enzyme small body-specific RNAs to bodies. Here, we show is overexpressed variety cancer cell lines different origin overexpression promotes transformation. Knockdown triggers massive apoptosis through mitochondrial pathway, demonstrated by...
Head and neck squamous cell carcinoma (HNSCC) is a malignancy that associated with severe mortality despite advances in therapy. Today's standard treatment most commonly includes radiotherapy, often combined chemotherapy or surgery. There are so far no established biomarkers to predict response radiation, thus the aim of this study was investigate series markers could potentially identify HNSCC patients who would benefit from radiotherapy. The selected markers, both proteins (epidermal...
Chemoresistant cancer cells express high levels of aldehyde dehydrogenases (ALDHs), particularly in head and neck squamous cell carcinoma (HNSCC). The ALDH family enzymes detoxify both exogenous endogenous aldehydes. Since many chemotherapeutic agents, such as cisplatin, result the generation cytotoxic aldehydes oxidative stress, we hypothesized that expressing may be more chemoresistant due to their increased detoxifying capacity inhibitors ALDHs sensitize them these drugs. Here, show...
// Lovisa Farnebo 1, 3 , Arash Shahangian Yunqin Lee June Ho Shin Ferenc A. Scheeren 2, John B. Sunwoo 1 Division of Head and Neck Surgery, Department Otolaryngology, Stanford University School Medicine, Stanford, CA, USA 2 The Netherlands Cancer Institute, Amsterdam, Institute the for Stem Cell Biology Regenerative University, Correspondence to: Sunwoo, e-mail: sunwoo@stanford.edu Keywords: head neck cancer, inflammation, tumorigenesis Received: December 12, 2014 Accepted: February 16, 2015...
Cancers of the head and neck have a high mortality rate, roughly 10% patients die within six months diagnosis. To our knowledge little has been written about this group. We wished to identify risk factors for early death, predict monitor at better and, if possible, avoid unjustified major treatment.This population-based nationwide study from Swedish Head Neck Cancer Register (SweHNCR) included data 2008-2015 9733 potential death. A total 925 (9.5%) died months. For every year older became,...
Abstract Background A significant proportion of patients with head and neck squamous cell carcinoma (HNSCC) are malnourished at diagnosis. In this study, we investigated how pretreatment body mass index (BMI) fat‐free (FFMI) correlate early death, whether these measurements useful markers prognosis for risk stratification cancer patients. Methods Patients ( n = 404) newly diagnosed, curable HNSCC WHO performance status 0–2 were prospectively included met a study representative before...
Background: The aim of this study was to evaluate biomarkers and biological characteristics tumor biopsies from patients with head neck cancer (HNC) assess the risk early death. Furthermore, we analyzed whether any combination markers could be used for prognostication death within six months after diagnosis. Materials Methods: Patients diagnosed HNC, receiving curative treatment decision at a multidisciplinary board meeting, who died diagnosis were included in study. Nine identified matched...
Purpose: Chronic rhinosinusitis (CRS) is related to asthma and chronic obstructive pulmonary disease (COPD). However, combined data on CRS, function, lower airway symptoms, cigarette smoking from the general population are lacking. The current study investigates relationships between CRS airflow limitation (CAL), symptoms COPD in a middle-aged of ever-smokers never-smokers. Patients Methods: All subjects Swedish CArdioPulmonary bioImage Study (SCAPIS) were included. Subjects underwent...
Background: Tendon-derived extracellular matrix (ECM) hydrogel has been shown to augment tendon healing in vivo. We hypothesized that reseeding of the gel with adipose-derived stem cells (ASCs) could further assist repopulation and combinations growth factors (GFs) would improve survival these after reseeding. Methods: A tendon-specific ECM solution was supplemented varying concentrations basic fibroblast factor (bFGF), insulin-like factor-1 (IGF-1), platelet-derived factor-BB (PDGF-BB)....
Background In general, survival outcomes for patients with Head and Neck Cancer (HNC) has improved over recent decades. However, mortality within six months after diagnosis curative remains at approximately 5%. The aim of this study was to identify risk factors early death among treatment, furthermore, analyze whether the changed years. Material method This real-world, population-based, nationwide from Swedish Register (SweHNCR) included all ≥18 years diagnosed HNC a treatment intent...
Radiotherapy is the main therapy for head and neck squamous cell carcinoma (HNSCC); however, treatment resistance local recurrence are significant problems, highlighting need predictive markers. In this study, we evaluated selected proteins, mutations, single nucleotide polymorphisms (SNPs) involved in apoptosis, proliferation, DNA repair alone or combined as markers radioresponse 42 HNSCC lines.The expression of epidermal growth factor receptor, survivin, Bax, Bcl-2, Bcl-X(L) ,...
The current treatment recommendation for T2-3N0M0 glottic squamous cell carcinoma (SCC) in the Nordic countries comprises of radiotherapy (RT) and chemoradiotherapy (CRT). Tumor radiosensitivity varies another option is primary surgical treatment, which underlines need predictive markers this patient population. aim present study was to investigate relation proteins WRAP53β, survivin p16INK4a RT/CRT response ultimate outcome patients with T2-T3N0 SCC. Protein expression determined using...
Conclusion: The management of Head and Neck Cancer Unknown Primary (HNCUP) patients varies both between centres within also the Nordic countries. This study contributes to a continuing discussion how improve accuracy diagnosis quality treatment HNCUP patients.Objectives: initiative for this was based on lack common guidelines diagnostic procedures in countries constituting region having rather homogeneous population.Method: A structured questionnaire sent all university hospitals five...
Abstract Background This exploratory, registry‐based, cross‐sectional study aimed to evaluate patients' health‐related quality of life (HRQOL) in a subsite oropharyngeal cancer: cancer the base tongue (CBT). Methods CBT patients, treated with curative intent, completed EORTC QLQ‐C30 and QLQ‐H&N35 questionnaires 15 months after diagnosis. The HRQOL patients was compared reference scores from general population that tonsillar carcinoma patients. Results 190 scored significantly worse than...
Abstract Background The health‐related quality of life (HRQOL) tonsillar carcinoma survivors was explored to investigate any HRQOL differences associated with tumor stage and treatment. survivors' also compared reference scores from the population. Methods In this exploratory cross‐sectional study patients were invited 15 months after their diagnosis asked answer two questionnaires (EORTC QLQ‐ C30, EORTC HN35), 405 participated. Results gender, males scoring better than females on a few...
The five Nordic countries with a population of 27M people form rather homogenous region in terms health care. management Head and Neck Cancer (HNC) is centralized to the 21 university hospitals these countries. Our aim was survey current status organization palliative care for patients HNC as field rapidly developing.
Background and purposeAn earlier prospective randomised multicentre study (ARTSCAN) in head neck cancer patients that compared conventionally fractionated radiotherapy (CF) with accelerated (AF) was inconclusive. In the subgroup of oral cavity squamous cell (OCSCC) a large absolute, but not statistically significant, difference local control seen favour AF. This more pronounced resectable tumours. The finding raised hypothesis AF could be beneficial for OCSCC patients. addition, longstanding...