A5056878004- Advanced Radiotherapy Techniques
- Head and Neck Cancer Studies
- Radiation Therapy and Dosimetry
- Prostate Cancer Diagnosis and Treatment
- Advances in Oncology and Radiotherapy
- Medical Imaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Radiomics and Machine Learning in Medical Imaging
- Oral health in cancer treatment
- Lung Cancer Treatments and Mutations
- Prostate Cancer Treatment and Research
- Colorectal and Anal Carcinomas
- Radiation Dose and Imaging
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Advanced MRI Techniques and Applications
- Cancer Genomics and Diagnostics
- Radiation Detection and Scintillator Technologies
- Dysphagia Assessment and Management
- Nutrition and Health in Aging
- Urologic and reproductive health conditions
- Radiation Effects and Dosimetry
- Esophageal Cancer Research and Treatment
- MRI in cancer diagnosis
Umeå University
2015-2024
Mayo Clinic Hospital
2023
University Hospital of Umeå
2007-2022
Institut Gustave Roussy
2021
Inserm
2021
Université Paris-Saclay
2021
Karolinska Institutet
1986-2021
Groupe d'Oncologie Radiothérapie Tête et Cou
2021
Centre de Radiothérapie Bayard
2017
Capio Lundby Sjukhus
2006
We performed an open-label randomized controlled phase III study comparing treatment outcome and toxicity between radiotherapy (RT) with concomitant cisplatin versus cetuximab in patients locoregionally advanced head neck squamous cell carcinoma (HNSCC; stage III-IV according to the Union for International Cancer Control TNM classification, 7th edition).Eligible were randomly assigned 1:1 receive either intravenous 400 mg/m2 1 week before start of RT followed by 250 mg/m2/wk, or weekly 40...
Weight loss is common among patients with squamous cell carcinoma of the head and neck (SCCHN) mainly due to tumor treatment related factors. The aim present study was evaluate weight in SCCHN undergoing two different radiotherapy (RT) schedules.Nutritional data were analyzed from ARTSCAN study, a controlled randomized prospective Swedish multicenter conducted comparing conventional fractionation (2.0 Gy per day, total 68 during 7 weeks) accelerated (1.1 + 2.0 4.5 weeks). Seven hundred fifty...
PurposeTo validate the dosimetric accuracy and clinical robustness of a commercially available software for magnetic resonance (MR) to synthetic computed tomography (sCT) conversion, in an MR imaging–only workflow 170 prostate cancer patients.Methods MaterialsThe 4 participating centers had MriPlanner (Spectronic Medical), atlas-based sCT generation software, installed as cloud-based service. A T2-weighted sequence, covering body contour, was added protocol. The images were sent from scanner...
We describe a public dataset with MR and CT images of patients performed in the same position both multiobserver expert consensus delineations relevant organs male pelvic region. The purpose was to provide means for training validation segmentation algorithms methods convert like data, i.e., so called synthetic (sCT).T1- T2-weighted as well data were collected 19 at three different departments. Five experts delineated nine each patient based on images. An automatic method used fuse...
The aim of this treatment planning comparison study was to explore different spinal irradiation techniques with respect the risk late side-effects, particularly radiation-induced cancer. radiotherapy compared were conventional photon therapy, intensity modulated x-ray therapy (IMXT), electron intensity/energy (IMET) and proton (IMPT).
A group of Swedish radiation oncologists and hospital physicists have estimated the number patients in Sweden suitable for proton beam therapy a facility where one principal aims is to facilitate randomized other studies which advantage protons can be shown magnitude differences compared with optimally administered conventional treatment, also including intensity-modulated (IMRT) brachytherapy, shown. The estimations been based on current statistics tumour incidence Sweden, potentially...
Trismus, a well-known sequelae after treatment of head and neck cancer, decreases patient's oral function quality life. The main objectives this study were to: 1) investigate the long-term prevalence radiation-induced trismus in patients treated for cancer according to two different fractionation schedules; 2) model dose–response relationship trismus.Material methods. Patients recruited from Swedish ARTSCAN trial, prospective randomised multicentre comparing conventional accelerated...
Background. In squamous cell carcinoma of the head and neck (SCCHN), overexpression p53 protein has been found in 34-80% tumors studied. No data are available regarding expression versus tumor proliferation prognosis for this type. Methods. levels were studied by immunohistochemical staining 33 primary SCCHN using 3 antibodies (D07, PAb 1801, CM1) that react with different epitopes protein. The cellular was compared vivo incorporation thymidine analog iododeoxyuridine (IdUrd) proliferating...
A programme of increased physical activity and self treatment based on the forced expiration technique was introduced to 14 adolescent patients with cystic fibrosis, diagnosed since infancy or early childhood, who had gastrointestinal pulmonary symptoms. Twelve fulfilled one year unchanged clinical conditions, function tests, chest x ray films. There a significant improvement in oxygen pressure correlated period activity. Other blood gas variables, including pH, standard bicarbonate, base...
Radiotherapy of head and neck malignancies is accompanied by oral discomforts, such as epithelitis, pain functional impairment. This can lead to chronic sequalae with subjective distress loss taste xerostomia pronounced decrease in quality life. Thus, the need reduce mucosal damage following radiotherapy obvious. Therefore, we investigated possible ability sucralfate, an aluminium hydroxide complex sulphated sucrose used treatment gastric ulcer, preventing discomfort patients treated...
The use of magnetic resonance (MR) imaging as a part preparation for radiotherapy is increasing. For delineation the prostate several publications have shown decreased variability using MR compared to computed tomography (CT). purpose present work was investigate intra- and inter-physician seminal vesicles, influence different sequence settings used clinically at five centers participating in study. series from centers, each providing patients, were used. Two physicians center delineated...
Weight loss is a common problem in patients with Squamous Cell Carcinoma of the Head and Neck (SCCHN) treated radiotherapy (RT). The aims present study were to determine if volume (TV), as measure radiation dose burden, can predict weight oropharyngeal cancer analyze body mass index (BMI) same patient group relation 5-year overall survival. ARTSCAN trial prospective, randomized, multicenter SCCHN. Nutritional data from analyzed retrospectively using univariate multivariate statistical...