Claes Mercke

ORCID: 0009-0008-2299-492X
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Research Areas
  • Head and Neck Cancer Studies
  • Advanced Radiotherapy Techniques
  • Lung Cancer Treatments and Mutations
  • Lung Cancer Diagnosis and Treatment
  • Heme Oxygenase-1 and Carbon Monoxide
  • Head and Neck Surgical Oncology
  • Effects of Radiation Exposure
  • Neonatal Health and Biochemistry
  • Ear and Head Tumors
  • Oral health in cancer treatment
  • Lung Cancer Research Studies
  • Salivary Gland Tumors Diagnosis and Treatment
  • Cancer Diagnosis and Treatment
  • Cancer survivorship and care
  • Prostate Cancer Treatment and Research
  • Medical Imaging Techniques and Applications
  • Esophageal Cancer Research and Treatment
  • Radiopharmaceutical Chemistry and Applications
  • Neuroendocrine Tumor Research Advances
  • Prostate Cancer Diagnosis and Treatment
  • Brain Metastases and Treatment
  • Lymphoma Diagnosis and Treatment
  • Cervical Cancer and HPV Research
  • Sarcoma Diagnosis and Treatment
  • Nutrition and Health in Aging

Karolinska University Hospital
2009-2024

Karolinska Institutet
2009-2024

Linköping University
2018

Stockholm University
2018

University of Oradea
2018

Sahlgrenska University Hospital
1998-2009

University of Gothenburg
1990-2004

Lund University
1980-2003

Linköping University Hospital
1996

Background The quality of life (QL) cancer patients has attracted an increasing interest in recent years. Patients with head and neck often have troublesome symptoms due to the disease treatment side effects, which will impact on patient's QL. aim this study was evaluate possibility studying QL relation well-known clinical parameters. Methods Patient's evaluated according European Organization for Research Treatment Cancer Quality Life Core Questionnaire (EORTC QLQ-C30) combined a...

10.1002/(sici)1097-0347(199809)20:6<540::aid-hed9>3.0.co;2-j article EN Head & Neck 1998-09-01

Abstract This study was designed to prospectively monitor the quality of life laryngeal cancer patients, compare patients with small tumors that large tumors, and test any difference in treated conventional versus hyperfractioned accelerated radiation therapy. Patients having had a laryngectomy within year were also analyzed separately. The European Organization for Research Treatment Cancer (EORTC) Quality Life Core Questionnaire (QLQ‐C30), EORTC Head Neck Module (H&amp;N‐37), Hospital...

10.1097/00005537-199805000-00023 article EN The Laryngoscope 1998-05-01

AbstractThe endogenous production of carbon monoxide (V˘O) was found to increase by 68 (range 16–150) per cent over baseline level after caloric restriction (380 kcal/36 h) in 8 healthy adults. Total serum bilirubin increased 50 (0–150) cent. No changes were seen total body heme, haptoglobin, or iron. Even though two cases with chronic unconjugated hyperbilirubinemia showed a more marked restriction, their V˙O within the range adults.Key Words: Bilirubincarbon monoxidefastingheme metabolism

10.3109/00365517209080280 article EN Scandinavian Journal of Clinical and Laboratory Investigation 1972-01-01

Background and purpose The of this study was to address the lack published data on use brachytherapy in pediatric rhabdomyosarcoma by describing current practice as starting point develop consensus guidelines. Materials methods An international expert panel treatment comprising 24 (pediatric) radiation oncologists, brachytherapists surgeons met for a Brachytherapy Workshop hosted European paediatric Soft tissue Sarcoma Study Group (EpSSG). panel's clinical experience, results previously...

10.1016/j.radonc.2024.110273 article EN cc-by Radiotherapy and Oncology 2024-04-07

Re-irradiation in head and neck cancer is challenging, cumulative dose constraints dose/volume data are scarce. In this study, we present for patients re-irradiated explore the correlations of to organs at risk severe side effects. We analyzed 54 between 2011 2017. Organs were delineated collected from treatment plans all included patients. Receiver–operator characteristics (ROC) analysis assessed association parameters toxicity. The ROC-curve a logistic model carotid blowout vs. maximum...

10.3390/cancers13133173 article EN Cancers 2021-06-25

In order to assess the value of radiotherapy in treatment pleural mesotheliomas, we studied tumour response and survival after hemithorax irradiation alone (RT), or combined with doxorubicin cyclophosphamide chemotherapy (RTCT). Forty seven patients mesotheliomas received diseased at 8 MV (megavolt) photons a total dose 40 Gy, administered 20 daily fractions 2 Gy for 5 days week. One month RT, aged &lt; = 70 yrs good performance status were offered supplementary (CT) 30 mg.m-2 body surface...

10.1183/09031936.96.09122565 article EN European Respiratory Journal 1996-12-01

We aimed to identify clinical significance of latent membrane protein 1 (LMP1), Ki-67, cyclin-B1, and epidermal growth factor receptor (EGFR), in nonendemic nasopharyngeal carcinoma (NPC).The relation between expression the markers 45 NPC specimens clinicopathological survival variables was statistically analyzed.LMP1 present 33% tumors, its presence associated with advanced nodal disease stages. Overexpression defined as labeling index > or = median value for 15% =50% EGFR, it displayed...

10.1002/hed.21002 article EN Head & Neck 2009-01-08

Methods. Twelve patients with advanced epithelial nonadenocarcinoma of the paranasal sinuses and nasal fossa were treated three cycles cisplatin (100 mg/ m2, day 1) 5-fluorouracil (1000 mg/m2/24 hours on days 1-5 by continuous infusion), followed preoperative external radiation therapy 48 Gy limited surgery, clearing fossa. Results. After chemotherapy, 11 12 free previous symptoms disease. Clinical response rates different, however, an overall rate approximately 70% no complete responses....

10.1002/1097-0142(19921201)70:11<2615::aid-cncr2820701108>3.0.co;2-g article EN Cancer 1992-12-01

During the 19-year period from 1970 to 1988, 289 cases of squamous cell carcinoma oral tongue were diagnosed in Western Sweden. In 230 these, treatment regimens and results analysed an attempt define prognostic factors for local control survival. Tumour stages were: T1 26%, T2 32%, T3 30% T4 13%. Nodal disease was seen 32% patients. Sixty per cent patients had surgery, 74% external with or without combination interstitial irradiation; received chemotherapy. The rate at five years 59% (T1...

10.3109/02841869309092450 article EN Acta Oncologica 1993-01-01

A retrospective study has been made of 302 patients with vocal cord carcinoma stage I and II treated between 1963 1983, emphasizing treatment failure patterns. the primary modalities were radiotherapy for 266 surgery 36 patients. minimum follow-up was 4 years. After there 63 local recurrences 7 neck lymph node recurrences, all appearing outside target volume. actuarial loco-regional recurrence-free rates at 5 years 78% Tl, 76% T2a (normal mobility) 60% T2b (imparied tumors. regional 99, 100...

10.3109/02841869109092386 article EN Acta Oncologica 1991-01-01

Abstract Total heme catabolism has been studied through measurement of the endogenous production carbon monoxide (V̇CO) in 8 patients with hemolysis, 7 hypoproliferative anemia, 10 refractory anemia and hypercellular bone marrow splenomegaly, 6 whom had myeloid metaplasia. Simultaneously, circulating red cell hemoglobin (Vheme‐c) was measured labelling cells 51 Cr, V̇CO/V̇heme‐c ratio calculated for each patient. From a control group it that this should vary around 1.5. Since no isotope...

10.1111/j.0954-6820.1975.tb04898.x article EN Acta Medica Scandinavica 1975-01-12
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