A5024275078- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Textile materials and evaluations
- Brain Metastases and Treatment
- Prostate Cancer Treatment and Research
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Metabolomics and Mass Spectrometry Studies
- Cancer therapeutics and mechanisms
- Material Properties and Processing
- Advanced Fiber Optic Sensors
- Intracranial Aneurysms: Treatment and Complications
- Advances in Oncology and Radiotherapy
- Angiogenesis and VEGF in Cancer
- Medical Imaging Techniques and Applications
- Chemotherapy-induced organ toxicity mitigation
- Lattice Boltzmann Simulation Studies
- Muscle activation and electromyography studies
- Mechanical Behavior of Composites
- Neutropenia and Cancer Infections
- Inflammatory Biomarkers in Disease Prognosis
- Generative Adversarial Networks and Image Synthesis
- Transcranial Magnetic Stimulation Studies
Essity (Sweden)
2021-2023
Chalmers University of Technology
2016-2023
Umeå University
2006-2020
Mid Sweden University
2018-2019
We employed stereotactic microdialysis to sample extracellular fluid intracranially from glioblastoma patients, before and during the first five days of conventional radiotherapy treatment. Microdialysis catheters were implanted in contrast enhancing tumor as well brain adjacent (BAT). Reference samples collected subcutaneously patients' abdomen. The analyzed by gas chromatography-time-of-flight mass spectrometry (GC-TOF MS), acquired data was processed hierarchical multivariate curve...
The knowledge of response to radiation in the immuno-microenvironment high grade gliomas is sparse. In vitro results have indicated an inflammatory myeloid cells after irradiation. Therefore, microdialysis was used verify whether this operative tumor tissue and brain adjacent (BAT) clinical radiotherapy patients with glioma. Stereotactic biopsies implantation catheters BAT were performed eleven high-grade given daily fractions 2–3.4 Gy. Microdialysis samples collected before during first...
Abstract OBJECTIVE Arteriovenous malformations (AVMs) are congenital vascular lesions that associated with high morbidity and mortality if left untreated. There several options for treatment, including radiotherapy. Safe effective single-fraction radiotherapy patients large AVMs has been considered difficult. METHODS Between December 1986 June 2001, 36 cerebral were treated hypofractionated conformal stereotactic at Umeå University Hospital. Twenty-nine have followed angiographically to date...
The use of magnetic resonance (MR) imaging as a part preparation for radiotherapy is increasing. For delineation the prostate several publications have shown decreased variability using MR compared to computed tomography (CT). purpose present work was investigate intra- and inter-physician seminal vesicles, influence different sequence settings used clinically at five centers participating in study. series from centers, each providing patients, were used. Two physicians center delineated...
High-grade gliomas are associated with poor prognosis. Tumour heterogeneity and invasiveness create challenges for effective treatment use of systemically administrated drugs. Furthermore, lack functional predictive response-assays based on drug efficacy complicates evaluation early responses.We used microdialysis to deliver cisplatin into the tumour monitor levels metabolic compounds present in non-malignant brain tissue adjacent tumour, before during treatment. In parallel, we collected...
Glioblastomas progress rapidly making response evaluation using MRI insufficient since treatment effects are not detectable until months after initiation of treatment. Thus, there is a strong need for supplementary biomarkers that could provide reliable and early assessment efficacy. Analysis alterations in the metabolome may be source identification new biomarker patterns harboring predictive information. Ideally, should found within an easily accessible compartment such as blood. Using...
We explore computational high-throughput screening as a design strategy for heterogeneous, isotropic fiber materials. Fluid permeability, key property in the of soft porous materials, is systematically studied using multi-scale lattice Boltzmann framework. After characterizing microscopic permeability function solid volume fraction microstructure, we perform excess 35 000 macrostructures consisting continuous bulk interrupted by spherical/elliptical domains with either lower or higher (hence...
Many products incorporate into their design fibrous material with particular levels of permeability as a way to control the retention and flow liquid. The production experimental testing these materials can be expensive time consuming, particularly if it needs optimised desired level absorbency. We consider parametric virtual fiber model replacement for real facilitate studying relationship between structure properties in cheaper more convenient manner. 3D image data sets sample are obtained...
Telemedicine as a tool for sharing competence in paediatric radiotherapy : implementation and initial experiences from Swedish project.
This paper concerns uniaxial compression of anisotropic fibre network, as typically seen in the end use nonwoven and textile assemblies. The constitutive relationship deformation mechanism have been investigated by using a bead-model to represent complex structures constituent fibres networks. stress shows power-law dependency on density with threshold for both experimental numerical Unlike widely studied tri-axial initially isotropic it was found that contact interaction between fibres,...
How to tell patients they have cinecr is; in important question cancer eure. The provokes distress physicians, and a railure relating the diagnosis may arrest patients' process of coping with anxiety reduce their subjective well-being. This contribution theory communicating about is empirically based on an earlier study which malignant brain tumors were interviewed theoretically contemporary object-relational psychoanalysis. authors propose that beneficial physician-patient encounter can be...
Hypofractionated radiotherapy has been used for the treatment of AVMs and brain metastases. Hypofractionation necessitates use a relocatable stereotactic frame that to be applied on several occasions. The needs have high degree reproducibility, patient positioning is crucial achieve accuracy treatment. In this study we have, by radiological means, evaluated reproducibility isocenter in consecutive sessions using Fixster frame. Deviations X, Y Z-axis were measured 10 patients treated with...
Background and purpose. The variability in target delineation for similar cases between centres treating paediatric adolescent patients, the apparent differences interpretation of radiotherapy guidelines treatment protocols encouraged us to perform a dummy-run study as part our quality assurance work. aim was identify quantify segmentation volumes organs at risk (OARs) analyse plans dose distributions. Materials methods. Four patient were selected: Wilm's tumour, Hodgkin's disease,...