A5102923361- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Breast Cancer Treatment Studies
- Cancer Cells and Metastasis
- Medical Imaging Techniques and Applications
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Coronary Interventions and Diagnostics
- Immune cells in cancer
- Numerical methods for differential equations
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- HER2/EGFR in Cancer Research
- Estrogen and related hormone effects
- Breast Lesions and Carcinomas
- Colorectal Cancer Surgical Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Model Reduction and Neural Networks
- Receptor Mechanisms and Signaling
- Acute Myocardial Infarction Research
- Colorectal Cancer Screening and Detection
- Advanced MRI Techniques and Applications
- Neuroscience and Neuropharmacology Research
Linköping University
2014-2025
Karlstad Central Hospital
2013-2022
Linköping University Hospital
2007-2021
Region Jönköpings län
2018
Dassault Systèmes (France)
2011-2017
Ryhov Hospital Jönköping
2015-2016
Region Östergötland
2013-2014
Society of Thoracic Surgeons
2013
Lund University
2011
University Hospital
2009
The instantaneous wave-free ratio (iFR) is an index used to assess the severity of coronary-artery stenosis. has been tested against fractional flow reserve (FFR) in small trials, and two measures have found similar diagnostic accuracy. However, studies clinical outcomes associated with use iFR are lacking. We aimed evaluate whether noninferior FFR respect rate subsequent major adverse cardiac events.
For muscle-invasive bladder cancer (MIBC), no tissue biomarkers are available for clinical use to predict response neoadjuvant chemotherapy.To investigate how molecular subtypes impact pathological and survival in patients receiving preoperative cisplatin-based chemotherapy.Classification of a retrospective cohort 149 was performed by tumor transcriptomic profiling immunostaining. A treated with radical cystectomy alone public data sets were used comparison external validation.Complete the...
Cells of the monocyte/macrophage lineage are important for tumour cell migration, invasion and metastasis. Fusion between macrophages cancer cells in animal models vitro vivo causes hybrids with increased metastatic potential. Primary breast were characterized macrophage antigens to test if phenotypic resemblance is related early distant recurrence. Immunostaining CD163, MAC387 CD68 was performed a tissue micro array from 127 patients consequently followed up median 13 years....
The aim of this study was to investigate the clinical outcomes patients deferred from coronary revascularization on basis instantaneous wave-free ratio (iFR) or fractional flow reserve (FFR) measurements in stable angina pectoris (SAP) and acute syndromes (ACS). Assessment stenosis severity with pressure guidewires is recommended determine need for myocardial revascularization. safety deferral pooled per-protocol population (n = 4,486) DEFINE-FLAIR (Functional Lesion Intermediate Stenosis...
Expression of the macrophage antigen CD163 in breast cancer cells is recently shown to be related early distant recurrence and shortened survival. In this study, 163 patients with rectal cancer, included Swedish trial followed up for a median 71 months, were examined expression primary tumors. The expressed tumors 23% (n = 32) patients. pretreatment biopsies from 101 patients, 10 had CD163-positive cancers these earlier local (p < 0.044) reduced survival time 0.045) compared those...
Cell fusion is a natural process in normal development and tissue regeneration. Fusion between cancer cells macrophages generates metastatic hybrids with genetic phenotypic characteristics from both maternal cells. However, there are no clinical markers for detecting cell context. Macrophage-specific antigen CD163 expression tumor reported breast colorectal cancers proposed being caused by macrophages-cancer stroma. The purpose of this study to examine the as biological explanation...
The thalamus is a neuroanatomic structure that has reciprocal connections with several brain regions suggested to be involved in the pathophysiology of schizophrenia. Recent studies have reported structural as well functional abnormalities aim present exploratory study was examine D2/D3 dopamine receptors anterior cingulate and frontal temporal cortices by using high-affinity radioligand [11C]FLB 457 positron emission tomography (3D PET) explore data relation disease, age psychopathology....
Current positron emission tomography (PET) radioligands for detection of Abeta amyloid in Alzheimer's disease (AD) are not ideal quantification. To improve the signal to noise ratio we have developed radioligand [(11)C]AZD2184 and report here first clinical evaluation.Eight AD patients four younger control subjects underwent 93-min PET measurements with [(11)C]AZD2184. A approach using cerebellum as reference region was applied determine binding parameters.Brain uptake peaked within 1 min at...
OBJECTIVE: The authors' goal was to test the hypothesis of extrastriatal D2 receptor selectivity as mechanism action clozapine. METHOD: Positron emission tomography (PET) used examine well striatal dopamine occupancy in four patients treated with clozapine and three haloperidol. reference radioligand [11C]raclopride for determination striatum. [11C]FLB 457 chosen thalamus, temporal cortex, frontal cortex. RESULTS: In haloperidol high all examined brain regions. clozapine-treated relatively...
The role of the epithelial-mesenchymal transition (EMT) in cancer has been studied extensively vitro, but involvement EMT tumorigenesis vivo is largely unknown. We investigated potential microRNAs as clinical markers and analyzed participation EMT-associated microRNA-200–ZEB–E-cadherin pathway progression. Expression microRNA-200 family was quantified by real-time RT-PCR analysis fresh-frozen microdissected formalin-fixed paraffin-embedded primary colorectal tumors, normal colon mucosa,...
We studied patients treated with radical cystectomy for locally advanced bladder cancer to compare the results of both preoperative positron emission tomography/computed tomography (PET/CT) and conventional CT findings postoperative histopathological evaluation lymph nodes.Patients who had were candidates underwent PET/CT using 18-fluorodeoxyglucose (FDG) CT. The regarding node involvement independently evaluated by two experienced radiologists subsequently compared histopathology results,...
Among 706 male, dizygotic, smoking discordant twin pairs born in 1901 to 1925, 13 deaths occurred among nonsmokers or less exposed partners against 34 smokers more exposed. In 246 corresponding monozygotic the figures were 14 9. The excess mortality male dizygotic was not associated with any specific cause of death. Four cases lung cancer males only smokers. Accidents and suicides seemed be smoking, supporting hypotheses regarding differences personality typebetween nonsmokers. Only time...
Background: The aim of this study was to evaluate biomarkers and biological characteristics tumor biopsies from patients with head neck cancer (HNC) assess the risk early death. Furthermore, we analyzed whether any combination markers could be used for prognostication death within six months after diagnosis. Materials Methods: Patients diagnosed HNC, receiving curative treatment decision at a multidisciplinary board meeting, who died diagnosis were included in study. Nine identified matched...
Resistance towards endocrine therapy is a great concern in breast cancer treatment and may partly be explained by the activation of compensatory signaling pathways. The aim present study was to investigate if insulin-like growth factor-1 receptor (IGF1R) pathway activated or deregulated patients explore any markers were prognostic, with without adjuvant tamoxifen. This has been suggested cause estrogen independent cell thus contribute resistance (ER) positive cancer. protein expression...