A5047816707- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Folate and B Vitamins Research
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Glutathione Transferases and Polymorphisms
- Solidification and crystal growth phenomena
- Cancer Mechanisms and Therapy
- CAR-T cell therapy research
- RNA Interference and Gene Delivery
- Viral-associated cancers and disorders
- RNA and protein synthesis mechanisms
- Metallurgical Processes and Thermodynamics
- Aluminum Alloy Microstructure Properties
- Phagocytosis and Immune Regulation
- Estrogen and related hormone effects
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Circular RNAs in diseases
- Bladder and Urothelial Cancer Treatments
Zhuhai People's Hospital
2024-2025
Sun Yat-sen University
2018-2025
Jinan University
2024-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2025
Qingdao University
2024
Yuhuangding Hospital
2024
Sun Yat-sen University Cancer Center
2021-2024
State Key Laboratory of Oncology in South China
2021
Background Platinum resistance is a major challenge in the clinical treatment of advanced ovarian cancer (OC). Accumulating evidence shows that tumor-promotive M2 macrophage linked to limiting chemotherapy efficacy multiple malignancies including OC. Circular RNAs (circRNAs) are novel class non-coding which function as critical regulator biological process cancer. However, their impact on polarization and chemoresistance OC remain unclear. Methods Platinum-resistant circRNAs were screened...
Abstract Background CD133 is considered a marker for cancer stem cells (CSCs) in several types of tumours, including hepatocellular carcinoma (HCC). Chimeric antigen receptor-specific T (CAR-T) targeting CD133-positive CSCs have emerged as tool the clinical treatment HCC, but immunogenicity, high cost clinical-grade recombinant viral vectors and potential insertional mutagenesis limit their application. Methods CD133-specific CAR-T secreting PD-1 blocking scFv (CD133 s cells) were...
Most patients with hepatocellular carcinoma (HCC) are in the middle or advanced stage at time of diagnosis, and therapeutic effect is limited. Therefore, this study aimed to verify whether deoxythymidylate kinase (DTYMK) increased HCC was an effective target HCC. The findings revealed that DTYMK level significantly correlated poor prognosis However, nothing else known, except could catalyze phosphorylation deoxythymidine monophosphate (dTMP) form diphosphate (dTDP). A number experiments were...
Bladder cancer (BC) is the ninth most common lethal malignancy worldwide. Great efforts have been devoted to clarify pathogenesis of BC, but underlying molecular mechanisms remain unclear. To screen for genes associated with progression and carcinogenesis three datasets were obtained from Gene Expression Omnibus. A total 37 tumor 16 non‑cancerous samples analyzed identify differentially expressed (DEGs). Subsequently, 141 identified, including 55 upregulated 86 downregulated genes. The...
Triple-negative breast cancer (TNBC) is associated with a worse prognosis and higher mortality than other cancers, intensive effort has been made to develop therapies targeting TNBC. TNBC shows expression levels of programmed cell death ligand 1 (PD-L1) types, which leads decrease in the killing effects CD8+ T cells tumor microenvironment. Inhibitors apoptosis proteins (IAPs) could prevent through suppressing caspase activity. Here, Birinapant, an antagonist IAPs, was found promote...
Abstract Hepatocellular carcinoma (HCC) has a pathogenesis that remains elusive with restricted therapeutic strategies and efficacy. This study aimed to investigate the role of SMG5, crucial component in nonsense-mediated mRNA decay (NMD) degrades containing premature termination codon, HCC resistance. We demonstrated an elevated expression SMG5 scrutinized its potential as target. Our findings revealed knockdown not only inhibited migration, invasion, proliferation cells but also influenced...
<div>Abstract<p>Hepatocellular carcinoma (HCC) has a pathogenesis that remains elusive with restricted therapeutic strategies and efficacy. This study aimed to investigate the role of <i>SMG5</i>, crucial component in nonsense-mediated mRNA decay (NMD) degrades containing premature termination codon, HCC resistance. We demonstrated an elevated expression <i>SMG5</i> scrutinized its potential as target. Our findings revealed knockdown not only inhibited...
Vasculogenic mimicry (VM) induced by Epstein-Barr virus (EBV) infection plays an important role in resistance to anti-vascular endothelial growth factor (VEGF) therapy EBV-associated epithelial cancers; however, the interaction between VM and immune microenvironment has not been systematically investigated.
<p>Supplementary Figure 1. Chemical structure of NMDl14</p>
<div>Abstract<p>Hepatocellular carcinoma (HCC) has a pathogenesis that remains elusive with restricted therapeutic strategies and efficacy. This study aimed to investigate the role of <i>SMG5</i>, crucial component in nonsense-mediated mRNA decay (NMD) degrades containing premature termination codon, HCC resistance. We demonstrated an elevated expression <i>SMG5</i> scrutinized its potential as target. Our findings revealed knockdown not only inhibited...
<p>Supplementary Figure 1. Chemical structure of NMDl14</p>