A5069691973- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phagocytosis and Immune Regulation
- Nanoplatforms for cancer theranostics
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Folate and B Vitamins Research
- Cancer-related gene regulation
- SARS-CoV-2 and COVID-19 Research
- Psychedelics and Drug Studies
- Fungal Biology and Applications
- RNA Research and Splicing
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Biological and pharmacological studies of plants
- COVID-19 Clinical Research Studies
- Cancer Mechanisms and Therapy
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- GABA and Rice Research
- Chemical synthesis and alkaloids
Sun Yat-sen University
2024
Sun Yat-sen University Cancer Center
2024
Beijing Institute of Education
2021
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
2021
Chinese Academy of Sciences
2013
Abstract Neutrophil extracellular traps (NET), formed by the release of decondensed chromatin and granules, have been shown to promote tumor progression metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone NET formation, highlighting need for a more comprehensive understanding mechanisms action NETs liver cancer. Here, we showed that DNA (NET-DNA) binds transmembrane coiled-coil domains 6 (TMCO6) on CD8+ T cells impair antitumor immunity thereby HCC...
Background Lycoris aurea, also called Golden Magic Lily, is an ornamentally and medicinally important species of the Amaryllidaceae family. To date, sequencing its whole genome unavailable as a non-model organism. Transcriptomic information scarce for this species. In study, we performed de novo transcriptome to produce first comprehensive expressed sequence tag (EST) dataset L. aurea using high-throughput technology. Methodology Principal Findings Total RNA was isolated from leaves with...
Abstract Hepatocellular carcinoma (HCC) has a pathogenesis that remains elusive with restricted therapeutic strategies and efficacy. This study aimed to investigate the role of SMG5, crucial component in nonsense-mediated mRNA decay (NMD) degrades containing premature termination codon, HCC resistance. We demonstrated an elevated expression SMG5 scrutinized its potential as target. Our findings revealed knockdown not only inhibited migration, invasion, proliferation cells but also influenced...
<div>Abstract<p>Hepatocellular carcinoma (HCC) has a pathogenesis that remains elusive with restricted therapeutic strategies and efficacy. This study aimed to investigate the role of <i>SMG5</i>, crucial component in nonsense-mediated mRNA decay (NMD) degrades containing premature termination codon, HCC resistance. We demonstrated an elevated expression <i>SMG5</i> scrutinized its potential as target. Our findings revealed knockdown not only inhibited...
<div>Abstract<p>Neutrophil extracellular traps (NET), formed by the release of decondensed chromatin and granules, have been shown to promote tumor progression metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone NET formation, highlighting need for a more comprehensive understanding mechanisms action NETs liver cancer. Here, we showed that DNA (NET-DNA) binds transmembrane coiled-coil domains 6 (TMCO6) on CD8<sup>+</sup> T cells impair...
<div>Abstract<p>Neutrophil extracellular traps (NET), formed by the release of decondensed chromatin and granules, have been shown to promote tumor progression metastasis. Tumor-associated neutrophils in hepatocellular carcinoma (HCC) are prone NET formation, highlighting need for a more comprehensive understanding mechanisms action NETs liver cancer. Here, we showed that DNA (NET-DNA) binds transmembrane coiled-coil domains 6 (TMCO6) on CD8<sup>+</sup> T cells impair...
<p>The effects of tumor-derived TGF-β1 on NET formation.</p>
<p>The representative dotplots used for gating strategies of flow staining CD8+ T cells in in-vivo experiments.</p>
<p>Association of NET expression with clinicopathological features in patients HCC.</p>
<p>Association of NET expression with clinicopathological features in patients HCC.</p>
<p>Pancancer analysis for the expression and prognosis value of TMCO6 in multiple cancer types.</p>
<p>The effects of tumor-derived TGF-β1 on NET formation.</p>
<p>Receiver operating characteristic curves analysis for NETs in HCC.</p>
<p>The representative dotplots used for gating strategies of flow staining NK, CD4+, CD8+ IFN-γ+, and granzyme B+ cells in in-vivo experiments.</p>
<p>Methods for Neutrophil isolation and culture, CD8+ T-cell Tumor-infiltrating lymphocyte isolation, Cell membrane protein NET-DNA purification biotin-labeling so on.</p>
<p>The expression and prognosis value of NETs in HB.</p>
<p>The expression of TMCO6 in HCC tissues and its role cell behaviors.</p>
<p>The expression of TMCO6 in HCC tissues and its role cell behaviors.</p>
<p>The expression of TMCO6 and its relationship with CD8+ T cell-immunity in HB.</p>
<p>TGF-β1-signaling inhibition or TMCO6 deficiency combined with anti-PD-1 abolishes NET-driven HCC progression in vivo.</p>
<p>NET-DNA regulates CD8+ T cell-immunity via TMCO6.</p>
<p>The prognostic value of TMCO6 in HB and its role cell behaviors.</p>
<p>Methods for Neutrophil isolation and culture, CD8+ T-cell Tumor-infiltrating lymphocyte isolation, Cell membrane protein NET-DNA purification biotin-labeling so on.</p>