A5102748728- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Protein Tyrosine Phosphatases
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Galectins and Cancer Biology
- COVID-19 Clinical Research Studies
- Reproductive System and Pregnancy
- RNA modifications and cancer
- Endometriosis Research and Treatment
- Neonatal Respiratory Health Research
- Advanced Glycation End Products research
- Biomarkers in Disease Mechanisms
- Andrographolide Research and Applications
- Inflammatory mediators and NSAID effects
- Occupational and environmental lung diseases
- Viral Infectious Diseases and Gene Expression in Insects
- Ferroptosis and cancer prognosis
- Fibroblast Growth Factor Research
- Glycosylation and Glycoproteins Research
- Psoriasis: Treatment and Pathogenesis
- Immune cells in cancer
China Pharmaceutical University
2020-2025
Nanjing University
2020-2025
Nanjing Drum Tower Hospital
2024
Xuzhou Medical College
2024
First Affiliated Hospital of Zhengzhou University
2019-2024
Dalian Medical University
2015-2018
Second Affiliated Hospital of Dalian Medical University
2017-2018
Abstract Epithelial mesenchymal transition (EMT) is a key progression that promotes pulmonary fibrosis (PF). Numb, phosphotyrosine-binding domain (PTB) protein, implicated with EMT. Nuclear factor erythroid 2-related factor2 (Nrf2) and its downstream proteins heme oxygenase-1 (HO-1) NAD(P)H: quinone oxidoreductase 1 (NQO1) constitute an important pathway of antioxidant defense signal for protecting against PF. It remains elusive whether Nrf2 Numb have potential relationship in EMT-mediated...
Abstract IFNγ is conventionally recognized as an inflammatory cytokine that plays a central role in antitumor immunity. Although it has been used clinically to treat variety of malignancies, low levels the tumor microenvironment (TME) increase risk metastasis during immunotherapy. Accumulating evidence suggests can induce cancer progression, yet mechanisms underlying controversial development remain unclear. Here, we reveal dose-dependent effect inducing stemness accelerate progression...
Psoriasis is a chronic inflammatory skin disease, often accompanied by increased infiltration of immune cells, especially neutrophils. However, the detailed mechanism neutrophil function in psoriasis progression remains unclear. Here, we found that both Src homology-2 domain-containing protein tyrosine phosphatase-2 (SHP2) and neutrophils were highly correlated to developing single-cell ribonucleic acid (RNA) sequencing experiment verification. The deficiency SHP2 significantly alleviated...
Gallic acid (GA) is an organic compound with phenolic properties that occurs naturally and can be found in Guizhi Fuling capsules, showcasing a wide range of biological functionalities.
Epithelial-mesenchymal transition (EMT) is considered to be the key event in formation of pulmonary fibrosis (PF). High-mobility group box 1 (HMGB1) a novel mediator EMT. Nuclear factor erythroid 2-related 2 (Nrf2) critical transcription for protecting against PF. However, it unknown relationship between Nrf2 and HMGB1 EMT-mediated Bleomycin (BLM)-induced PF Nrf2-knockout (Nrf2-/- ) wild-type (WT) mice transforming growth β1 (TGF-β1)-induced EMT rat type II alveolar epithelial cell line...
Pneumonia is a common illness that continues to be the major killer of remaining significant source morbidity and mortality in patient population. Many microorganisms cause pneumonia, now concern turning importance new therapies for viral pneumonia. In current study, we report effect andrographolide sulfonate, water-soluble form (trade name: Xi-Yan-Ping Injection), on poly I: C-induced Andrographolide sulfonate was administrated through intraperitoneal injection mice with Recruitment airway...
Abstract Sterile inflammation occurs in various chronic diseases due to many nonmicrobe factors. Examples include endometrial hyperplasia (EH), endometriosis, cancer, and breast which are all sterile induced by estrogen imbalances. However, how estrogen‐induced regulates EH remains unclear. Here, a single‐cell RNA‐Seq is used show that SHP2 upregulation endothelial cells promotes their inflammatory activation subsequent transendothelial macrophage migration. Independent of the initial...
Therapies targeting programmed cell death protein 1 (PD-1) have gained great success in patients with multiple types of cancer. The regulatory mechanisms underlying PD-1 expression been extensively explored. However, the impact long noncoding RNAs on remains elusive. In this study, we identified Notch1/lncNDEPD1 axis, which plays a critical role human CD8+ T cells. RNA sequencing and quantitative reverse transcription PCR data showed that lncNDEPD1 was upregulated activated cells, especially...
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Abstract Psoriasis is a chronic inflammatory disease which infiltrated large number of neutrophils among skin lesions. Here, we investigated the contribution tyrosine phosphatase SHP2 in neutrophils, as well it’s pathogenesis psoriasis. We combined single-cell RNA sequencing with experimental verification to declare that could promote NETs formation through ERK5 pathway, and resulted infiltration immune cells, leads Our study provides evidence for role NETosis progression psoriasis, may be...
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Abstract
Background: Excessive deposition of extracellular matrix(ECM) is the common feature pulmonary fibrosis(PF). Epithelial-mesenchymal transition(EMT) an important mechanism in formation ECM PF. Emerging studies indicated that Forkhead box O 1(FOXO1), a transcription factor involved regulating EMT, plays vital role development fibrosis disease. Previous showed high mobility group 1(HMGB1) can aggravate EMT BLM-induced However, whether FOXO1 participates during PF with HMGB1 involving process has...
Background: Fibroblast to myofibroblast differentiation(FMD) is an important feature of pulmonary fibrosis(PF), which promotes collagen deposition and leads the destruction lung tissue structure. Recent studies suggested that autophagy involved in progression PF. However, it remains elusive whether can inhibit FMD during development In addition, AMPK-FOXO3a pathway induce many tissue, but no research has shown this participate pathogenesis
Background: Pulmonary fibrosis is characterized by the excessive accumulation of extracellular matrix synthesized from activated fibroblasts. X box binding protein 1(XBP-1) a transcription factor regulating various cellular functions, including unfold responses.While few studies aimed to investigate function unspliced XBP1 in fibroblast differentiation. Here we explore role uXBP1 differentiation during pulmonary fibrosis.