A5063572528- Mechanisms of cancer metastasis
- Polymer Nanocomposite Synthesis and Irradiation
- Chromatin Remodeling and Cancer
- Autism Spectrum Disorder Research
- Peptidase Inhibition and Analysis
- Rice Cultivation and Yield Improvement
- Genetics and Neurodevelopmental Disorders
- Signaling Pathways in Disease
- Soil Carbon and Nitrogen Dynamics
- Metalloenzymes and iron-sulfur proteins
- RNA modifications and cancer
- Silicone and Siloxane Chemistry
- Agriculture, Soil, Plant Science
- Adenosine and Purinergic Signaling
- Macrophage Migration Inhibitory Factor
- Cancer Mechanisms and Therapy
- Flame retardant materials and properties
- GABA and Rice Research
- Environmental and Agricultural Sciences
- Soil and Water Nutrient Dynamics
- Polymer Foaming and Composites
- Cancer, Hypoxia, and Metabolism
- Carbon dioxide utilization in catalysis
- Constructed Wetlands for Wastewater Treatment
- Tribology and Wear Analysis
Songjiang District Central Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Jiangsu Academy of Agricultural Sciences
2010-2024
Ministry of Agriculture and Rural Affairs
2019-2024
Lanzhou University
2024
Jiangsu University of Technology
2024
Center for Excellence in Brain Science and Intelligence Technology
2016-2023
Chinese Academy of Sciences
1994-2023
Shanghai Institutes for Biological Sciences
2014-2022
Shaoxing University
2022
Abstract Climate warming affects soil carbon (C) dynamics, with possible serious consequences for C stocks and atmospheric CO 2 concentrations. However, the mechanisms underlying changes in storage are not well understood, hampering long‐term predictions of climate C‐feedbacks. The activity extracellular enzymes ligninase cellulase can be used to track predominant sources microbes thus provide mechanistic insights into loss pathways. Here we show, using meta‐analysis, that reductions...
Hierarchical nanocomposites of aligned polyaniline nanorods on reduced graphene oxide nanosheets are synthesized in an <italic>in situ</italic> polymerization process.
ARID1A is a key mammalian SWI/SNF complex subunit that mutated in 5% to 11% of lung cancers. Although recent studies have elucidated the mechanism underlying dysregulation switch/sucrose non-fermentable (SWI/SNF) complexes cancers, significance loss and its implications cancers remain poorly defined. This study investigates how affects initiation progression cancer. In genetically engineered mouse models bearing mutant Kras deficient Trp53 allele (KP), (KPA) promoted tumorigenesis. Analysis...
Abstract The response rate of pancreatic cancer to chemotherapy or immunotherapy is low. Although minimally invasive irreversible electroporation (IRE) ablation a promising option for irresectable cancers, the immunosuppressive tumour microenvironment that characterizes this type enables recurrence. Thus, strengthening endogenous adaptive antitumour immunity critical improving outcome therapy and post-ablation immune therapy. Here we present hydrogel microsphere vaccine amplifies anti-cancer...
Mitochondria are critical cellular energy resources and central to the life of neuron. Mitophagy selectively clears damaged or dysfunctional mitochondria through autophagic machinery maintain mitochondrial quality control homeostasis. Mature neurons postmitotic consume substantial energy, thus require highly efficient mitophagy pathways turn over mitochondria. Recent evidence indicates that is pivotal pathogenesis neurological diseases. However, more work needed study pathway components as...
Analysis of cell-free DNA (cfDNA) is promising for broad applications in clinical settings, but with significant bias towards late-stage cancers. Although recent studies have discussed the diverse and degraded nature cfDNA molecules, little known about its impact on practice analysis.We developed single-strand library preparation hybrid-capture-based sequencing (SLHC-seq) to analysis fragments. Next we used SLHC-seq perform profiling 112 pancreatic cancer patients, results were compared 13...
Abstract Metabolic reprogramming by oncogenic signaling is a hallmark of cancer. Hyperactivation Wnt/β-catenin has been reported in hepatocellular carcinoma (HCC). However, the mechanisms inducing hyperactivation and strategies for targeting this pathway are incompletely understood. In study, we find nucleoside diphosphate kinase 7 (NME7) to be positive regulator signaling. Upregulation NME7 positively correlated with clinical features HCC. Knockdown inhibited HCC growth vitro vivo, whereas...
Bifunctional Fe 2 O 3 could activate H and N 4 ·H to reduce nitrobenzene, in which the –NO group was involved hydrogenation process.
Abstract The increase of fossil‐fuel burning and nitrogen (N) fertilizer consumption continues to elevate global N deposition, leading significant increases soil NH 4 + NO 3 − concentrations, thus 2 O emissions. This is especially important for natural, unmanaged soils which are considered as areas that sensitive input. However, uncertainties exist regarding the interactions emissions with concentrations in response input different climatic regions, well their underlying potential...
Base editing stands at the forefront of genetic engineering, heralding precise modifications with broad implications. While CRISPR-based DNA and RNA base systems capitalize on sgRNA-guided specificity diverse deaminase functionalities, pursuit efficient C-to-U has been hampered by inherent constraints cytidine deaminases. Here, we report an platform refining deaminases, termed professional APOBECs (ProAPOBECs), through systematic enhancements AI-driven protein engineering. ProAPOBECs...