A5100322896- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Sperm and Testicular Function
- RNA modifications and cancer
- Nuclear Structure and Function
- Reproductive Biology and Fertility
- Ovarian function and disorders
- Renal and related cancers
- CRISPR and Genetic Engineering
- DNA Repair Mechanisms
- Pluripotent Stem Cells Research
- Neuroscience and Neuropharmacology Research
- Axon Guidance and Neuronal Signaling
- Genomics and Chromatin Dynamics
- Microbial Community Ecology and Physiology
- Acute Myeloid Leukemia Research
- Photosynthetic Processes and Mechanisms
- Endometriosis Research and Treatment
- Cryospheric studies and observations
- Connective Tissue Growth Factor Research
- Ovarian cancer diagnosis and treatment
- Cytokine Signaling Pathways and Interactions
- Climate change and permafrost
- RNA Research and Splicing
- Genomics and Phylogenetic Studies
Chinese Academy of Sciences
2014-2025
Nanjing Hydraulic Research Institute
2025
University of Chinese Academy of Sciences
2012-2025
Sichuan University
2012-2025
Institute of Genetics and Developmental Biology
2021-2025
Center for Agricultural Resources Research
2025
Hebei Normal University
2025
West China Second University Hospital of Sichuan University
2025
Xiamen University
2024
Dalian Institute of Chemical Physics
2016-2024
BackgroundCCN family, comprising six members (Cyr61, CTGF, Nov, WISP-1, WISP-2, WISP-3), is involved in the stimulation of cell proliferation, migration, adhesion, angiogenesis, and tumorigenesis. Several studies have shown that expression Cyr61, WISP-1 affects tumorigenic potential lung cancer cells vitro. However, correlation CCN family proteins clinical features remains unknown.Methodology Principal FindingsIn present work, we quantified mRNA levels samples from 60 primary cancers their...
Connective tissue growth factor (CTGF or CCN2), a member of the CCN family, is involved in diverse biological processes such as cell adhesion, proliferation, and angiogenesis. In this study, we show that overexpression CTGF occurred significant proportion esophageal squamous carcinoma (ESCC) samples were high tumor grade metastatic. Forced expression Eca109 ESCC cells accelerated their culture significantly increased formation nude mice, whereas RNA interference-mediated knockdown inhibited...
Ferritin-like molecules are unique to cellular iron homeostasis because they can store at concentrations much higher than those dictated by the solubility of Fe(3+). Very little is known about protein interactions that deliver for storage or promote mobilization stored from ferritin-like molecules. Here, we report X-ray crystal structure Pseudomonas aeruginosa bacterioferritin (Pa-BfrB) in complex with bacterioferritin-associated ferredoxin (Pa-Bfd) 2.0 Å resolution. As first example a...
Recognition of methylated histone tail lysine residues by tudor domains plays important roles in epigenetic control gene expression and DNA damage response. Previous studies revealed the binding methyllysine a cage aromatic residues, but molecular mechanism which sequence specificity for surrounding is achieved remains poorly understood. In crystal structure trimethylated H3 4 (H3K4) peptide bound to tudor-like Spindlin1 presented here, an atypical mode recognition pocket observed....
Cloning of macaque monkeys by somatic cell nucleus transfer (SCNT) allows the generation with uniform genetic backgrounds that are useful for development non-human primate models human diseases. Here, we report feasibility this approach SCNT fibroblasts from a monkey (Macaca fascicularis), in which core circadian transcription factor BMAL1 was knocked out clustered regularly interspaced short palindromic repeat/Cas9 gene editing (see accompanying paper). Out 325 embryos transferred into 65...
Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic diseases among women reproductive age. Inflammation may be involved in pathogenesis PCOS, but its exact relationship with PCOS remains unclear. Herein, we investigate causal association between systemic inflammatory regulators risk through a two-sample Mendelian randomization (MR) approach based on latest largest genome-wide study (GWAS) 41 8293 Finnish participants GWAS meta-analysis consisting 10,074 cases...
Protein methylation is receiving more and attention for its important regulating role in diverse biological processes including epigenetic regulation of gene transcription, RNA processing, DNA damage repair, signal transduction. Global analysis protein at the proteome level requires enrichment methylated peptides with various forms; unfortunately, immunoaffinity purification method can only enrich a subset them due to lacking pan specific antibody. Because does not significantly alter...
Abstract During meiotic prophase I, telomeres attach to and move on the nuclear envelope (NE), regulating chromosome movement promote homologous pairing. Meiosis-specific proteins TERB1, TERB2 MAJIN play a key role in this process. Here, we report crystal structures of human TERB1-TERB2 TERB2-MAJIN subcomplexes. Specific disruption or interaction mouse Terb2 gene abolishes telomere attachment NE causes aberrant pairing disordered synapsis. In addition, depletion SUN1 also partially disrupts...
Abstract Comprehensive land surface models are very important for climate and weather forecasting improving our understanding of the relationships between humans Earth system. This work presents a model Chinese Academy Sciences (CAS‐LSM) that considers groundwater lateral flow, human water regulation, soil freeze‐thaw front dynamics, riverine dissolved inorganic nitrogen transport, anthropologic heat release, urban usage, planning based on Community Land Model. Global simulations with...
Abstract Chromosomes pair and synapse with their homologous partners to segregate correctly at the first meiotic division. Association of telomeres LINC (Linker Nucleoskeleton Cytoskeleton) complex composed SUN1 KASH5 enables telomere-led chromosome movements telomere bouquet formation, facilitating precise pairwise alignment homologs. Here, we identify a direct interaction between Speedy A (SPDYA) determine crystal structure human SUN1-SPDYA-CDK2 ternary complex. Analysis meiosis prophase I...
A one-pot palladium-catalyzed procedure for the synthesis of aryl phosphonates, phosphinates and phosphine oxides from phenols mediated by sulfuryl fluoride.
Teratozoospermia is usually associated with defective spermiogenesis and a disorder considerable genetic heterogeneity. Although previous studies have identified several teratozoospermia-associated genes, the etiology remains unknown for majority of affected men. Here, we homozygous missense mutation compound heterozygous CCIN in patients suffering from teratozoospermia. encodes cytoskeletal protein Calicin that involved formation maintenance highly regular organization calyx mammalian...
Abstract Activated protein C (APC) is a plasma serine protease with antithrombotic and cytoprotective functions. Based on the hypothesis that specific inhibition of APC’s anticoagulant but not its activity can be beneficial for hemophilia therapy, 2 types inhibitory monoclonal antibodies (mAbs) are tested: A type I active-site binding mAb II to an exosite APC (required activity) as shown by X-ray crystallography. Both mAbs increase thrombin generation promote clotting. Type blocks all...
Background As the prevalence of osteoporotic fractures increases, impacting health aging population significantly, understanding genetic link between chronic diseases such as primary biliary cholangitis (PBC) and osteoporosis (OP) is crucial. Despite existing research, direct relationship these conditions remains unclear. Materials Methods This study used a two-sample Mendelian randomization approach, drawing on largest available genome-wide association studies. Instrumental variables were...
The multi-model ensemble (MME) approaches are highly regarded in climate prediction and risk assessment for their capacity to integrate multiple global models (GCMs) minimize uncertainties associated with individual models. However, the quantitative impacts of spatial scale, weighted ensemble, bias correction on spatiotemporal comprehensive performance MME remain unknown. In this study, we comprehensively assessed historical simulation capabilities 41 CMIP6 GCMs at national, basin, grid...