A5100762374- Bone Tumor Diagnosis and Treatments
- Oral and Maxillofacial Pathology
- Musculoskeletal synovial abnormalities and treatments
- Immune cells in cancer
- Sarcoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Maternal and fetal healthcare
- Ectopic Pregnancy Diagnosis and Management
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Ovarian cancer diagnosis and treatment
- Genomics, phytochemicals, and oxidative stress
- Circular RNAs in diseases
- Colorectal and Anal Carcinomas
- Extracellular vesicles in disease
- FOXO transcription factor regulation
- Pregnancy-related medical research
- Pharmacogenetics and Drug Metabolism
- Reproductive System and Pregnancy
- MicroRNA in disease regulation
- Public Health and Nutrition
- Pancreatic and Hepatic Oncology Research
- Endometrial and Cervical Cancer Treatments
Shanghai Jiao Tong University
2014-2023
Renji Hospital
2013-2023
Pudong Medical Center
2023
Fudan University
2023
The Wistar Institute
2016-2019
University of Pennsylvania
2016-2019
Shanghai First People's Hospital
2017-2019
Ruijin Hospital
2017-2018
Qingdao University
2004
Qingdao Women and Children's Hospital
2004
Tumor-associated macrophages (TAMs) are classified into two major phenotypes, M1 and M2. TAMs suppress cancer progression, while M2 promote it. However, little is known regarding the role of in development ovarian cancer. Here, we investigated relationship between TAM distribution patterns (density, microlocalization, differentiation) histotypes, explored whether altered influence long-term outcomes patients. A total 112 patients were enrolled this study, subjects divided groups according to...
Inconsistencies in the half-maximal (50%) inhibitory concentration (IC50) data for anticancer chemotherapeutic agents have yielded irreproducible experimental results and thus reciprocally contradictory theories modern cancer research. The MTT assay is currently most extensively used method IC50 measurements. Here, we dissected critical reasons behind MTT-dependent inconsistencies. We showed that errors caused by technical deficiencies of are large not adjustable (range: 300-11,000%). To...
// Ran Liu 1, * , Huiting Wei 2, Peng Gao 3 Hu Yu 4 Ke Wang Zheng Fu 2 Baohui Ju 5 Meng Zhao Shangwen Dong 6 Zhijun Li Yifeng He 7 Yuting Huang and Zhi Yao 1 Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science Technology, University, Tianjin, 300072, China Department Immunology, Cellular Molecular Educational Ministry China, Basic Medical Sciences, 300071, University the District Columbia, Washington D.C., 20008, United States Cancer...
Cisplatin is commonly used in ovarian cancer chemotherapy, however, chemoresistance to cisplatin remains a great clinical challenge. Oncogenic transcriptional factor FOXM1 has been reported be overexpressed cancer. In this study, we aimed investigate the potential role of cancers with cisplatin. Our results indicate that upregulated chemoresistant samples, and defends cells against cytotoxicity facilitates DNA repair through regulating direct target EXO1 protect from cisplatin-mediated...
Mucin 2 (MUC2) is a mucin molecule aberrantly expressed by ovarian cancer cells. Previous in vitro studies have indicated that MUC2 promotes growth and metastasis through tumor-associated macrophage (TAM)-dependent mechanism. However, this mechanism has never been linked to clinical oncology, its prognostic significance needed be clarified. Here, we collected 102 consecutive specimens used the multiple immuno-histo-chemical/-fluorescent technique determine correlations between expression...
The number of cesarean scar pregnancy (CSP) has significantly increased in the recent decade. Although uterine artery embolization (UAE) been adopted to minimize blood loss during curettage removing CSP, massive bleeding and rupture can still be frequently encountered. aim this study was compare efficacy safety a novel combined laparoscopy hysteroscopy technique with traditional conceptus repairing incision defect following UAE management CSP.The CSP patients (n = 58) diagnosed between March...
CA125 is a prevalently used serum biomarker for detecting ovarian cancer over the last three decades. However, it has significant deficiency in screening early-stage cancer. With purpose of exploring an effective approach to improve its performance early diagnosis, we investigated postprandial fluctuation pattern cancer-derived and underlying mechanism.In two medical centers, 551 patients sonographically diagnosed with (adnexal) cysts (< 5 cm diameter) were enrolled divided into five disease...
Cervical lesions caused by integrated human papillomavirus (HPV) infection are highly dangerous because they can quickly develop into invasive cancers. However, clinicians currently hampered the lack of a quick, convenient and precise technique to detect integrated/mixed infections various genotypes HPVs in cervix. This study aimed practical tool determine physical status different evaluate its clinical significance.The target population comprised 1162 women with an HPV history > six months...
Objective To identify the prognostic factors for local recurrence of giant cell tumor bone (GCTB) through assessment preoperative imaging features border. Methods Patients with GCTBs treated intralesional procedures in proximal tibia and distal femur were prospectively enrolled then followed up at least 2 years. The grouped according to their features. en bloc resection investigation pathologic basis specific Differences between rates evaluated by chi-square test or Fisher’s exact test;...
P16INK4A is a surrogate signature compensating for the specificity and/or sensitivity deficiencies of human papillomavirus (HPV) DNA and Papanicolaou smear (Pap) co-test detecting high-grade cervical squamous intraepithelial lesions or worse (HSIL+). However, traditional p16INK4A immunostaining labour intensive skill demanding, subjective biases cannot be avoided. Herein, we created high-throughput, quantitative diagnostic device, flow cytometry (FCM) assessed its performances in cancer...
Giant cell tumor of bone (GCTB) is among the most prevalent types in East and Southeast Asia. The high rate local recurrence following intralesional curettage poses a challenge for clinical treatment GCTB. In present study, expression matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), receptor activator nuclear factor-κB (RANK) RANK ligand (RANKL) GCTB was investigated by immunohistochemical staining. A correlation between preoperative magnetic resonance imaging...
Multidrug resistance is a major cause of death in patients with ovarian cancer. To improve patient survival, we developed novel, noninvasive and convenient tool, the 75‐gram oral glucose (75gOG)‐stimulated CA125 test, to monitor cancer chemoresistance real time. Our vitro proof‐of‐principal experiments revealed that post‐75gOG insulin peaks can synergistically increase cancer‐derived levels, secretion (ΔCA125) correlated overactivation receptor (IR)‐PI3K‐Akt axis increases (ΔIC 50 s)...
Abstract CD47 is highly expressed in many malignant diseases including ovarian cancer, and renders cells resistant to phagocytosis by macrophages. Anti-CD47 mAbs have shown anti-cancer effects several types of cancers. However, it remains controversial whether anti-CD47 promote the inhibition function or CD47-SIRPα independent opsonization. We tried provide more evidence our study knocking down CD47. expression 93 patients was tested flow-cytometry. confirmed a positive correlation between...