A5040438923- interferon and immune responses
- Intracerebral and Subarachnoid Hemorrhage Research
- Cell death mechanisms and regulation
- Escherichia coli research studies
- NF-κB Signaling Pathways
- Gut microbiota and health
- Phytochemical compounds biological activities
- Urological Disorders and Treatments
- Bioactive Natural Diterpenoids Research
- Immune cells in cancer
- PARP inhibition in cancer therapy
- Systemic Lupus Erythematosus Research
- Parkinson's Disease and Spinal Disorders
- Peptidase Inhibition and Analysis
- DNA Repair Mechanisms
- Eicosanoids and Hypertension Pharmacology
- Inflammatory Biomarkers in Disease Prognosis
- Phagocytosis and Immune Regulation
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- Monoclonal and Polyclonal Antibodies Research
- RNA regulation and disease
- Renal Diseases and Glomerulopathies
- Bladder and Urothelial Cancer Treatments
Guangxi Medical University
2025
Chengdu University of Traditional Chinese Medicine
2020-2024
Harvard University
2017-2018
Tianjin Medical University
2013-2017
Apoptosis and necroptosis are two distinct cell death mechanisms that may be activated in cells on stimulation by TNFα. It is still unclear, however, how apoptosis differentially regulated. Here we screened for E3 ubiquitin ligases could mediate necroptosis. We found deficiency of Pellino 1 (PELI1), an ligase, blocked show PELI1 mediates K63 ubiquitination K115 RIPK1 a kinase-dependent manner during Ubiquitination promotes the formation necrosome execution Although not directly involved...
// Ran Liu 1, * , Huiting Wei 2, Peng Gao 3 Hu Yu 4 Ke Wang Zheng Fu 2 Baohui Ju 5 Meng Zhao Shangwen Dong 6 Zhijun Li Yifeng He 7 Yuting Huang and Zhi Yao 1 Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science Technology, University, Tianjin, 300072, China Department Immunology, Cellular Molecular Educational Ministry China, Basic Medical Sciences, 300071, University the District Columbia, Washington D.C., 20008, United States Cancer...
Abstract Parkin (Park2), a RING-between-RING-type E3 ubiquitin ligase, has been implicated in regulating NF-κB. Mutations are associated with Parkinson’s disease. Here we investigated the interaction of Receptor-interacting protein kinase 1 (RIPK1) kinase, key mediator multiple signaling pathways activated by TNFR1 including NF-κB pathway. We report that interacts RIPK1 and mediates K63 ubiquitination on K376 TNFR1-signaling The expression promotes recruitment transforming growth factor β...
Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections and plays a role in prostatic carcinogenesis prostate cancer (PCa) progression. However, mechanisms through which UPEC promotes PCa development progression are unclear. Cytotoxic necrotizing factor 1 (CNF1) one most important toxins its has never been studied. We found that UPEC-secreted CNF1 promoted migration invasion cells metastasis. In vitro studies showed pro-migratory pro-invasive activity entering...
Background This study aimed to investigate the prognostic value of pretreatment lactate dehydrogenase albumin ratio (LAR) in advanced non-small cell lung cancer (NSCLC) patients treated with first-line programmed death protein 1 (PD-1) checkpoint inhibitors and chemotherapy. Methods A retrospective cohort was conducted on NSCLC PD-1 plus chemotherapy at Guangxi Medical University Cancer Hospital. The receiver operating characteristic (ROC) analysis determined optimal LAR cutoff values for...
Shenkang Injection (SKI) is a traditional Chinese medicine injection commonly used in the clinical treatment of chronic kidney disease. Although it has been confirmed that SKI anti-kidney fibrosis effects, underlying mechanism remains unclear. To investigate effects on epithelial-mesenchymal transition (EMT) and Wnt/β-catenin pathway explore its potential anti-fibrosis mechanism. A unilateral ureteral obstruction (UUO) model was induced by ligating left ureter male SD rats. total 24 rats...
Urinary tract infections (UTIs) are one of the most common bacterial in humans, causing cystitis, pyelonephritis, and renal failure. Uropathogenic Escherichia coli (UPEC) is leading cause UTIs. Accurate rapid discrimination UPEC lineages useful for epidemiological surveillance. Fimbriae necessary adherence strains to host uroepithelia, seem be abundant diverse strains. By analyzing all possible fimbrial operons strains, we found that closely related had similar types chaperone-usher...
Tyroserleutide (YSL) is an active, low-molecular-weight polypeptide with in vitro and vivo anticancer effects on human hepatocellular carcinoma BEL-7402 cells. In this study, we studied the of YSL PI3K/AKT cells to explore its anti-tumor mechanism. Results showed that could up-regulate mRNA protein expression tumor suppressor PTEN increase their activities, meanwhile inhibited oncogene AKT decreased kinase activities PDK1. The resuming balance effect between prevent transmission cell...
Camptocormia is a postural deformity that characterized by markedly flexed lumbar spine, with symptoms worsen walking and standing. Here, we report case of camptocormia associated Parkinson's disease.A 70-year-old man 7-year history disease presented fall injury caused lower back pain for 3 months was aggravated 2 months. He had been diagnosed compression fracture after the undergone percutaneous kyphoplasty at local hospital. MRI showed non-union L1 vertebra L2. The patient underwent...
Abstract Introduction Oridonin possesses remarkable anti-inflammatory, immunoregulatory properties. However, the renoprotective effects of oridonin and underlying molecular mechanisms in diabetic nephropathy (DN). We hypothesized that could ameliorate diabetes‑induced renal fibrosis. Methods Streptozocin (STZ)-induced rats were provided with a high-fat diet to establish type 2 diabetes mellitus (T2DM) animal model, then treated (10, 20 mg/kg/day) for two weeks. Kidney function fibrosis...
Abstract Background : Oxidative stress and its induced inflammation are important pathological processes of diabetic nephropathy (DN). Oridonin, a component isolated from Rabdosia rubescens, possesses remarkable anti-inflammatory, immunoregulatory properties, it is also newly reported NLRP3 inhibitor. However, the renoprotective effects Oridonin underlying molecular mechanisms have not been explored in DN. We hypothesized that could reduce pathway ameliorate diabetes‑induced renal fibrosis....