A5100448116- Immune Response and Inflammation
- Viral Infections and Vectors
- Vector-borne infectious diseases
- Parasites and Host Interactions
- Immune Cell Function and Interaction
- interferon and immune responses
- Vector-Borne Animal Diseases
- Macrophage Migration Inhibitory Factor
- Cytokine Signaling Pathways and Interactions
- Vitamin D Research Studies
- Pharmacological Effects of Natural Compounds
- Antimicrobial Peptides and Activities
- Pain Mechanisms and Treatments
- Bioactive Compounds and Antitumor Agents
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Vasculitis and related conditions
- Immune cells in cancer
- Peroxisome Proliferator-Activated Receptors
- Renal Diseases and Glomerulopathies
- Alkaloids: synthesis and pharmacology
- Liver Diseases and Immunity
- Toxoplasma gondii Research Studies
- Inflammasome and immune disorders
Chinese PLA General Hospital
2025
Chinese People's Liberation Army
2025
AbbVie (United States)
2023
Chengdu University of Traditional Chinese Medicine
2022
State Key Laboratory of Reproductive Medicine
2021
Nanjing Medical University
2016-2021
Beijing Ditan Hospital
2018
307th Hospital of Chinese People’s Liberation Army
2018
Tianjin University
2017
Yangzhou University
2015-2016
// Ran Liu 1, * , Huiting Wei 2, Peng Gao 3 Hu Yu 4 Ke Wang Zheng Fu 2 Baohui Ju 5 Meng Zhao Shangwen Dong 6 Zhijun Li Yifeng He 7 Yuting Huang and Zhi Yao 1 Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science Technology, University, Tianjin, 300072, China Department Immunology, Cellular Molecular Educational Ministry China, Basic Medical Sciences, 300071, University the District Columbia, Washington D.C., 20008, United States Cancer...
Colitis-associated cancer (CAC) is the most serious outcome of inflammatory bowel disease, which has an alteration commensal intestinal microbiota. However, role microbiota on CAC progression not well understood. Fecal transplantation (FMT) was used for treating murine azoxymethane–dextran sodium sulfate (AOM-DSS) model CAC. Composition gut during FMT treatment analyzed. RT-PCR and ELISA were to detect factors, immunofluorescence applied examine phospho-NF-κB p65/p100 Ki67 positive cells in...
Background: The host-parasite relationship is based on subtle interplay between parasite survival strategies and host defense mechanisms. It well known that helminth infection, which afflicts more than one billion people globally, correlates with a decreased prevalence of obesity. Dissecting the underlying mechanisms can provide new targets for treating obesity from interaction perspective. Methods: C57BL/6 mice received normal or high-fat diet (HFD) without Sjp40 (one main component...
Amelioration of concanavalin A-induced autoimmune hepatitis by magnesium isoglycyrrhizinate through inhibition CD4+CD25-CD69+ subset proliferation Qi Yang,1,* Jianwei Wang,2,* Ran Liu,2 Zhiqiang Wang,1 Yufeng Li,2 Yifan Zhang,1 Xiaohua Hao,2 Yubo Huang,2 Wen Xie,2 Hongshan Wei1,2 1Beijing Ditan Teaching Hospital, Peking University Health Science Center, Beijing, People's Republic China; 2Institute Infectious Disease, Beijing Capital Medical University, China *These authors contributed...
Mesangial proliferative glomerulonephritis (MsPGN) is the most common pathological type, including IgA nephropathy (IgAN), in which regional immune injury leads to disease progression without targeted treatment approaches. The mechanism of MsPGN unclear. We previously performed single-cell RNA sequencing (scRNA-seq) IgAN and identified that CX3CR1 gene increased kidney. In this study, further scRNA-seq analysis cellchat revealed CX3CL1 expression was mesangial cells monocytes/macrophages,...
Objective Peroxisome proliferator‐activated receptor (PPAR)‐γ plays critical roles in human metabolic disorders. However, the mechanism remains incompletely understood. Regulatory cells contribute to these improvements; therefore, whether PPAR‐γ agonist regulates regulatory was investigated. Methods C57BL/6J mice received a normal or high‐fat diet (HFD) with without pioglitazone treatment. Mice were sacrificed for detecting parameters. Lymphocytes from spleen and visceral adipose tissue...
Epidemiological studies in China have revealed that Schistosoma japonicum infection is inversely correlated with metabolic syndrome, even after repeated chemotherapy praziquantel (PZQ). We investigated the effect of chronic S. infection, PZQ chemotherapy, and soluble egg antigen (SEA) treatment on whole-body homeostasis hepatic insulin sensitivity mouse models.Infection was found to increase mice. significantly improved physiological status infected mice, maintaining Th2 immune-deviation...
Background . Peroxisome proliferator-activated receptor- (PPAR-) γ plays critical roles in human metabolic disorders and has recently been implicated as a regulator of cellular proliferation inflammatory responses. Regulatory T cells (Tregs), which express high levels PPAR- protein, have the ability to maintain immune tolerance self-antigens regulate response Schistosoma infection. However, mechanisms involved resolution these responses are elusive. Methods Liver spleen tissue samples...
The interferon-induced proteins with tetratricopeptide repeats (IFITs) protein family mediates antiviral effects by inhibiting translation initiation, cell proliferation, and migration in the interferon (IFN) dependent innate immune system. Several members of this family, including IFIT1, IFIT2, IFIT3 IFIT5, have been heavily studied mammals. Avian species contain only one member, little is known about role birds. In study, duck IFIT5 (duIFIT5) full-length mRNA was cloned reverse...
Retinoic acid-inducible gene I- (RIG-I-) like receptors (RLRs) have recently been identified as cytoplasmic sensors for viral RNA. RIG-I, a member of RLRs family, plays an important role in innate immunity. Although previous investigations proved that RIG-I is absent chickens, it remains largely unknown whether the chicken can respond to ligand. In this study, eukaryotic expression vectors encoding duRIG-I full length (duck containing all domains), N-terminal (containing two caspase...
Summary With increasing antibiotic resistance and drug safety concerns, novel therapeutics are urgently needed. Antimicrobial peptides promising candidates that could address the spread of multidrug‐resistant pathogens. HPRP ‐A1/A2 known to display antimicrobial activity against gram‐negative bacteria, gram‐positive bacteria some pathogenic fungi, but whether work on Toxoplasma gondii ( T ) is unknown. In this study, we found viability tachyzoites received treatment was significantly...
Amestolkins A (1) and B (2), two previously undescribed phthalides sharing the same planar structure of (1, 5-dihydroxyhexyl)-7-hydroxyisobenzofuran-1(3H)-one were isolated from Talaromyces amestolkiae. Their absolute configurations elucidated by comprehensive analyses spectroscopic evidences in high-resolution electrospray mass spectra (HRESIMS) nuclear magnetic resonance (NMR) combined with electronic circular dichroism (ECD) NMR calculations. 1 2 showed anti-neuroinflammatory activity...
Pressure pain thresholds (PPTs) have been shown to be useful measures of mechanical sensitivity in deep tissues. However, clinical methods for measuring allodynia or hyperalgesia teeth not reported. The aim this study was assess the reliability PPTs periodontal ligament healthy Chinese participants. Twenty young adults participated. were measured at six and two directions. tests included three consecutive trials, separate sessions, which performed on first day by one examiner. After 1-3 wk,...
Background/Aims: The elaborate structure of the extracellular matrix (ECM) and appropriate surface glycoforms upon it are indispensable to CD4+ T cell regulation. Methods: To explore effects Glcα1,2Galβ1 glycosylation mediated by GLT25D2 (Colgalt2) for regulation, we prepared C57BL/6J Glt25d2-/- mice. In induction hepatitis, after concanavalin A (Con A) challenge 6, 12, 24 h, more extensive parenchymal injury was noted in mice than wild-type (WT) at 12 h. Immunohistochemistry laser scanning...