A5100696935- Ginger and Zingiberaceae research
- Cardiac Fibrosis and Remodeling
- Traditional Chinese Medicine Analysis
- Nanoparticle-Based Drug Delivery
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Nanoplatforms for cancer theranostics
- Natural product bioactivities and synthesis
- Atherosclerosis and Cardiovascular Diseases
- Essential Oils and Antimicrobial Activity
- Protease and Inhibitor Mechanisms
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Inflammasome and immune disorders
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Traditional Chinese Medicine Studies
- Curcumin's Biomedical Applications
- Cardiovascular Function and Risk Factors
- Advanced Glycation End Products research
- Flavonoids in Medical Research
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Advanced Drug Delivery Systems
- Connective Tissue Growth Factor Research
Guiyang Medical University
2016-2025
Affiliated Hospital of Guizhou Medical University
2016-2023
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2018
Xinjiang Medical University
2018
Tumor Hospital of Xinjiang Medical University
2018
Nanyang Medical College
2012
Southwest Hospital
2006-2009
Army Medical University
2006-2009
Sun Yat-sen University
2005
Third Affiliated Hospital of Sun Yat-sen University
2005
1,8-Cineole, the main component of volatile oil in aromatic plants, has diverse pharmacological properties, including antioxidant, anti-inflammatory, and anti-cancer properties. Diabetic retinopathy (DR) is a common microvascular complication diabetes mellitus (DM). Here, we investigated protective effect 1,8-cineole on DR found that treatment could alter expression several genes both high glucose (HG)-induced ARPE-19 cells retinal tissues DM mice, as well inhibit ferroptosis. Subsequent...
1,8-Cineole (eucalyptol), a monoterpene, has been widely reported for the anti-inflammatory effects. Our previous data confirmed that 1,8-cineole ameliorated inflammatory phenotype of human umbilical vein endothelial cells (HUVECs) by mediating NF-κB expression in vitro. At present, we investigated protection effects on vascular endothelium lipopolysaccharide (LPS)-induced acute injury mice and potential mechanisms involved HUVECs. Results from enzyme linked immunosorbent assays revealed...
We previously demonstrated oxymatrine, an alkaloid from the Chinese medicine radix Sophorae flavescentis, ameliorates hemodynamic disturbances and cardiac fibrosis; however, underlying mechanisms are unclear. Here, we investigated effect mechanism of action oxymatrine on aldosterone-induced fibroblast to myofibroblast differentiation in vitro. Cardiac fibroblasts were isolated purified neonatal Sprague Dawley rats. The optimal concentration aldosterone stimulate proliferation was determined...
Abstract Diabetic cardiomyopathy (DCM) is the principal cause of death in people with diabetes. However, there currently no effective strategy to prevent development DCM. Although cyclovirobuxine D (CVB-D) has been widely used treat multiple cardiovascular diseases, possible beneficial effects CVB-D on DCM remained unknown. The present aim was explore potential and underlying mechanisms We explored by using high fat sucrose diet streptozotocin-induced rat model. Cardiac function survival...
Diabetic cardiomyopathy (DCM) is one of the common complications diabetic patients, which can induce myocardial hypertrophy, cardiac fibrosis, and heart failure. Growing evidence has shown that occurrence development DCM are accompanied by pyroptosis an NLRP3-mediated intense inflammatory cell death. Cyclovirobuxine D (CVB-D) been to significantly ameliorate anti-inflammatory effects associated with cardiomyopathy, but it unclear whether effect on cardiomyocyte accompanying DCM. Therefore,...
Salvianolic acid B (Sal B), a water-soluble phenolic compound derived from Salvia miltiorrhiza Bunge, is commonly used in Traditional Chinese Medicine to treat cardiovascular disease. In our previous study, Sal protected against myocardial fibrosis induced by diabetic cardiomyopathy (DCM). This study aimed investigate the ameliorative effects and potential mechanisms of mitigating DCM.Various methods were on DCM vivo vitro. These included blood glucose measurement, echocardiography, HE...
Abstract The extracellular matrix protein fibronectin (FN) facilitates tumorigenesis and the development of breast cancer. Inhibition FN-induced cellular response is a potential strategy for cancer treatment. In present study, we investigated effects flavonoid baicalein on epithelial–mesenchymal transition (EMT) in MCF-10A epithelial cells transgenic mouse MMTV-polyoma middle T antigen model (MMTV-PyMT). Baicalein inhibited migration, invasion, F-actin remodeling. also suppressed...
Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that predominantly affects elderly individuals across the globe. While genetic, environmental, and lifestyle factors are known to influence onset of AD, underlying mechanisms remain unclear. Objective To elucidate intricate interplay between metabolites immune cell activation in ethology determine their collective impact on AD risk. Methods We conducted comprehensive analysis genome-wide association studies data...