A5077554557- Nanoparticles: synthesis and applications
- Ethnobotanical and Medicinal Plants Studies
- Cell death mechanisms and regulation
- Retinoids in leukemia and cellular processes
- Phytochemicals and Medicinal Plants
- Chronic Lymphocytic Leukemia Research
- Phytochemistry and Biological Activities
- Autophagy in Disease and Therapy
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- PI3K/AKT/mTOR signaling in cancer
- Asthma and respiratory diseases
- Nanoparticle-Based Drug Delivery
- Sesquiterpenes and Asteraceae Studies
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Plant biochemistry and biosynthesis
- Sirtuins and Resveratrol in Medicine
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Natural Antidiabetic Agents Studies
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Phytochemistry and Bioactive Compounds
Guiyang Medical University
2018-2025
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2018-2024
University of Madras
2011-2019
The most practical approach to reduce morbidity and mortality of cancer is delay the process carcinogenesis by usage anticancer agents. This necessitates that safer compounds are be critically examined for activity especially, those derived from natural sources. A spice commonly found in India surrounding regions, turmeric, rhizome Curcuma longa major active component a phytochemical termed curcumin. Green tea one popular beverages used worldwide, produced leaves evergreen plant Camellia...
Abstract Diabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal glycolipid metabolism critical factor that affects the occurrence development of DCM. Additionally, upregulation/activation silent information regulation 2 homolog‐1 (SIRT1) has been shown protect against Tanshinone II A (Tan IIA), main active component Salviae miltiorrhizae radix et rhizome (a valuable...
Abstract The ETS transcription factor Fli-1 controls the expression of genes involved in hematopoiesis including cell proliferation, survival, and differentiation. Dysregulation induces hematopoietic solid tumors, rendering it an important target for therapeutic intervention. Through high content screens a library chemicals isolated from medicinal plants China inhibitors transcriptional reporter cells, we hereby report identification diterpenoid-like compounds that strongly inhibit activity....
Abstract Background FLI1 is an oncogenic transcription factor that promotes diverse malignancies through mechanisms are not fully understood. Herein, shown to regulate the expression of Ubiquitin Associated and SH3 Domain Containing A/B ( UBASH3A/B ) genes. UBASH3B UBASH3A found act as oncogene tumor suppressor, respectively, their combined effect determines erythroleukemia progression downstream FLI1. Methods Promoter analysis with luciferase assays chromatin immunoprecipitation (ChIP) were...
Wiskott-Aldrich Syndrome, WAS/WAVE, is a rare, X-linked immune-deficiency disease caused by mutations in the WAS gene, which together with its homolog, N-WASP, regulates actin cytoskeleton remodeling and cell motility. patients suffer from microthrombocytopenia, characterized diminished number size of platelets, though underlying mechanism not fully understood. Here, we identified FLI1 as direct transcriptional regulator binding partner WIP. Depletion either or WIP human erythroleukemic...
Previous reports have suggested that Idesia polycarpa Maxim. (I. polycarpa) fruits possess properties for the prevention and treatment of non-alcoholic fatty liver disease (NAFLD), owing to its lipid-lowering anti-oxidant activities. In this study, ethyl acetate extract (EAE) I. supplementation reduced body weight gain inflammatory cytokines secretion, improved glucose tolerance insulin sensitivity, alleviated hepatic steatosis in high-fat diet (HFD)-fed mice. Of note, a total eight...
E26 transformation‐specific ( ETS ) gene family contains a common DNA ‐binding domain, the responsible for sequence‐specific recognition on target promoters. The Fli‐1 oncogene, member of family, plays critical role in hematopoiesis and is overexpressed diverse hematological malignancies. This transcription factor regulates genes controlling several hallmarks cancer thus represents an excellent therapy. By screening compounds isolated from medicinal plant Dysoxylum binectariferum China, we...
An unrevealed dihydroflavone‐monoterpene conjugate (1), two kavalactones (2‐3, including one with an uncommon side chain), and thirteen previously identified compounds (4‐16) were extracted from Alpinia katsumadai Hayata. seeds. The two‐dimension structures of the new authenticated utilizing HRESIMS as well NMR spectral analysis, while their absolute chiral configurations ascertained either by correlating experimental simulated values electronic circular dichroism (ECD) patterns or...
Plaque psoriasis is an inflammatory skin disorder affecting nearly 2% of the world population. Despite recent advances in treatment, there still a need for more effective therapies. The ETS transcription factor FLI1 plays critical roles hematopoiesis, angiogenesis, immunity, and cancer. Emerging evidence suggests that intricately involved processes underlying pathogenesis. RNAseq bioinformatic analysis were used to identify correlation between levels expression genes associated with...
In the domain of image processing and manipulation, style transfer has emerged as a revolutionary technique that allows fusion artistic styles onto photographic content. This technology been leveraged in recent years fields varied content creation, fashion design augmented reality among others. Despite significant advancements, conventional methods often struggle with preserving input while accurately infusing desired style. Significant computational overheads are also incurred during...
MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types cancers. A plethora drugs were developed to block this kinase pathway for clinical application. With the exception recently identified agent, EQW, most these inhibitors target upstream factors but not ERK1/2; no activator ERK1/2 currently available. library compounds isolated medicinal plants China was screened...