A5073847451- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Heavy Metal Exposure and Toxicity
- Drug Transport and Resistance Mechanisms
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Acute Myeloid Leukemia Research
- Traditional Chinese Medicine Analysis
- Kruppel-like factors research
- Retinoids in leukemia and cellular processes
- Platelet Disorders and Treatments
- Coronary Interventions and Diagnostics
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Gut microbiota and health
- Drug-Induced Hepatotoxicity and Protection
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Autophagy in Disease and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Trace Elements in Health
- Peptidase Inhibition and Analysis
- Medicinal Plants and Neuroprotection
- Psoriasis: Treatment and Pathogenesis
- Toxoplasma gondii Research Studies
Guiyang Medical University
2020-2025
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2020-2025
Zunyi Medical University
2018-2023
Shanghai Institute of Materia Medica
2022
Chinese Academy of Sciences
2022
Cytochrome P450s (CYPs) are phase-I metabolic enzymes playing important roles in drug metabolism, dietary chemicals and endogenous molecules. Age is a key factor influencing expression. Thus, age-related changes of CYP 1–4 families bile acid homeostasis-related CYPs, the corresponding nuclear receptors few phase-II genes were examined. Livers from male Sprague-Dawley rats at fetus (−2 d), neonates (1, 7, 14 weanling (21 puberty (28 35 adulthood (60 180 aging (540 800 d) collected subjected...
Abstract Background FLI1 is an oncogenic transcription factor that promotes diverse malignancies through mechanisms are not fully understood. Herein, shown to regulate the expression of Ubiquitin Associated and SH3 Domain Containing A/B ( UBASH3A/B ) genes. UBASH3B UBASH3A found act as oncogene tumor suppressor, respectively, their combined effect determines erythroleukemia progression downstream FLI1. Methods Promoter analysis with luciferase assays chromatin immunoprecipitation (ChIP) were...
Wiskott-Aldrich Syndrome, WAS/WAVE, is a rare, X-linked immune-deficiency disease caused by mutations in the WAS gene, which together with its homolog, N-WASP, regulates actin cytoskeleton remodeling and cell motility. patients suffer from microthrombocytopenia, characterized diminished number size of platelets, though underlying mechanism not fully understood. Here, we identified FLI1 as direct transcriptional regulator binding partner WIP. Depletion either or WIP human erythroleukemic...
Oxidative stress induced by high ammonia, which lead to astrocyte edema, is the key acute hepatic encephalopathy (AHE). Nuclear factor erythroid 2-related 2 (NRF2) has been implicated in oxidative stress, but mechanism of NRF2 against ammonia-induced astrocytes edema not fully studied. We confirmed that pathway related brain caused AHE, and found Xiaochaihutang (XCHT) could effectively activate treat AHE. The model AHE was established with thioacetamide (TAA) rats. Rat behaviors were...
Plaque psoriasis is an inflammatory skin disorder affecting nearly 2% of the world population. Despite recent advances in treatment, there still a need for more effective therapies. The ETS transcription factor FLI1 plays critical roles hematopoiesis, angiogenesis, immunity, and cancer. Emerging evidence suggests that intricately involved processes underlying pathogenesis. RNAseq bioinformatic analysis were used to identify correlation between levels expression genes associated with...
Lovastatin, an HMG-CoA inhibitor and effective cholesterol lowering drug, exhibits anti-neoplastic activity towards several types of cancer, although the underlying mechanism is still not fully understood. Herein, we investigated growth inhibition leukemic cells by lovastatin.RNAseq analysis was used to explore effect lovastatin on gene expression in cells. An animal model leukemia test this statin vivo. FAM83A DDIT4 knocked-downed via lentivirus-shRNA. Western blotting, RT-qPCR, cell cycle...
During hematopoiesis, megakaryocytic erythroid progenitors (MEPs) differentiate into or lineages in response to specific transcriptional factors, yet the regulatory mechanism remains be elucidated. Using MEP‑like cell line HEL western blotting, RT‑qPCR, lentivirus‑mediated downregulation, flow cytometry as well chromatin immunoprecipitation (ChIp) assay demonstrated that E26 transformation‑specific (ETS) transcription factor friend leukemia integration 1 (Fli‑1) inhibits differentiation. The...
Aim: Histamine decarboxylase (HDC) catalyzes decarboxylation of histidine to generate histamine. This enzyme affects several biological processes including inflammation, allergy, asthma, and cancer, although the underlying mechanism is not fully understood. The present study provides a novel insight into relationship between transcription factor FLI1 its downstream target HDC, their effects on inflammation leukemia progression. Methods: Promoter analysis combined with chromatin...
Intimal hyperplasia is the major therapeutic concern after percutaneous coronary intervention. The aim of this study to investigate effects 2,3,4',5-tetrahydroxystilbene-2-O-β-D glucoside (TSG) on intimal and underling mechanisms through attenuating expressions stromal cell-derived factor-1α (SDF-1α)/CXCR4, stem cell factor (SCF)/c-kit fractalkine (FKN)/CX3CR1, promoting re-endothelialization with vascular endothelial growth (VEGF).Rats were operated carotid artery balloon injury. treatment...
In the theory of traditional Chinese medicine (TCM), "liver-qi" stagnation and heat-induced toxicity represent main etiologies breast cancer. Recently, several TCMs with heat-clearing detoxification efficacy have shown inhibitory effects on Jin'gan capsules (JGCs), initially approved to treat colds in China, are a TCM formula. However, anticancer activity JGCs against cancer its underlying mechanisms remain unclear. First, we assessed antiproliferative cell lines evaluated their apoptosis...
Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good poor prognosis, but the underlying mechanisms are largely unknown. The limonoid compounds A1542 and A1543 stimulate ERK/MAPK by direct binding, leading to leukemic cell death suppression leukemia mouse models. this study, we investigated downstream consequences these agonists cells.We...
Abstract Purpose Breast cancer is the most frequent in women with significant death rate. Morbidity associated drug resistance and metastasis. Development of novel drugs unmet need. The aim this study to show potent anti-neoplastic activity UM171 compound on breast cells its mechanism action. Methods inhibitory effect several (BC) cell lines was examined using MTT colony-forming assays. Cell cycle apoptosis assays were utilized determine BC proliferation survival. Wound healing scratch...
Astragalus membranaceus (AM) herb is a component of traditional Chinese medicine used to treat various cancers. Herein, we demonstrate strong anti-leukemic effect AM injected (Ai) into the mouse model erythroleukemia induced by Friend virus. Chemical analysis combined with mass spectrometry AM/Ai identified compounds Betulinic acid, Kaempferol, Hederagenin, and formononetin, all major mediators leukemia inhibition in culture vivo. Docking demonstrated binding these four FLI1, resulting...
Leukemia is responsible for a reason of death, globally. Even though there are several treatment regimens available in the clinics against this disease, perfect chemotherapeutic agent same still under investigation. Natural plant-derived secondary metabolites used to treat leukemia better benefits with reduced side-effects. Likely, bioactive compounds from Callistemon sp. were reported their benefits. Furthermore, acylphloroglucinol derivatives salignus, showed both antimicrobial and...
The pyrimido-indole derivative UM171 promotes human Hematopoietic Stem Cells Expansion (HSCE), but its impact on leukemia is not known. Herein, we show in a mouse model of erythroleukemia that strongly suppresses progression. inhibits cell cycle progression and apoptosis leukemic cells culture. effect differentiation was accompanied by increased expression HSCE markers. RNAseq analysis combined with Q-RT-PCR western blotting revealed the PIM1 protein kinase highly elevated response to...