A5100341619- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Bone health and osteoporosis research
- Cancer-related gene regulation
- RNA Research and Splicing
- Bone health and treatments
- Insect Resistance and Genetics
- Circular RNAs in diseases
- Bone and Dental Protein Studies
- Epigenetics and DNA Methylation
- Spaceflight effects on biology
- Cellular Mechanics and Interactions
- Ubiquitin and proteasome pathways
- Insect-Plant Interactions and Control
- Autophagy in Disease and Therapy
- RNA Interference and Gene Delivery
- Biochemical and Molecular Research
- Viral gastroenteritis research and epidemiology
- CRISPR and Genetic Engineering
- Advances in Cucurbitaceae Research
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
Anhui Science and Technology University
2022-2025
Zhejiang A & F University
2023-2025
Shanghai Jiao Tong University
2021-2025
Nanjing Medical University
2022-2025
Shanghai Agrobiological Gene Center
2019-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Jiangsu Province Hospital
2022-2025
Shanghai Ninth People's Hospital
2022-2025
State Forestry and Grassland Administration
2025
Jiangxi Agricultural University
2024-2025
Abstract A novel strategy for asymmetric Shono‐type oxidative cross‐coupling has been developed by merging copper catalysis and electrochemistry, affording C1‐alkynylated tetrahydroisoquinolines with good to excellent enantioselectivity. The use of TEMPO as a co‐catalytic redox mediator is crucial not only oxidizing tetrahydroisoquinoline an iminium ion species but also decreasing the oxidation potential reaction. bisoxazoline ligand reported.
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Imidacloprid (IC) is a systemic insecticide related to the tobacco toxin nicotine. IC toxic substance frequently used into combat insects, rodents and plants pests other creatures that can pose problems for agriculture. We, therefore, planned this study assess risk factors, biochemical histological alterations associated with hepatotoxicity nephrotoxicity. Forty-eight adult male albino mice were divided four groups of 12 animals each. All given standard synthetic pellet diet. One group...
PJA2 is documented to degrade various substrates. Nevertheless, the role of as an E3 ubiquitin-protein ligase in colorectal cancer (CRC) progression remains unexplored. The correlation between mRNA levels and clinical characteristics investigated using data from Cancer Genome Atlas (TCGA) database. Quantitative real-time polymerase chain reaction (qRT-PCR) immunohistochemistry (IHC) are utilized evaluate expression CRC tissues. biological functions confirmed through colony formation assays...
Salt stress is a major abiotic constraint limiting rice (Oryza sativa L.) production worldwide, particularly in saline-affected regions. Improving salt tolerance at the seed germination stage crucial for increasing stand establishment and yield stability, especially under direct seeding conditions. Identifying loci associated with salt-tolerant characterizing key candidate genes offers valuable insights breeding strategies. We evaluated of 406 drought-resistant accessions 0, 100, 150, 200 mM...
Osteoporosis is a degenerative bone disease in aging men and women. MiRNAs associated with progressive loss osteoporosis had not been clearly demonstrated.The evaluation of the differentially expressed miRNAs tissue serum osteoporotic women aging.MiRNAs GeneChip real-time PCR were used to screen differently tissues 21 ages 60-69 years 80-89 years. Identified detected validation cohort, which consisted 14 healthy premenopausal 86 postmenopausal osteopenia or osteoporosis. MiR-181c-5p...
Background: Irisin, a novel exercise-induced myokine, was shown to mediate beneficial effects of exercise in osteoporosis. Microgravity is major threat bone homeostasis astronauts during long-term spaceflight, which results decreased formation. Methods: The hind-limb unloading mice model and random position machine are respectively used simulate microgravity vivo vitro. Results: We demonstrate that not only formation osteoblast differentiation decreased, but the expression fibronectin type...
Abstract Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) has been proven to participate in the ubiquitination of multiple substrate proteins. However, underlying mechanisms UBE2J1 as a ubiquitin-conjugating participating cancer development and progression remain largely unknown. Here, we identified that is downregulated colorectal (CRC) tissues cell lines which are mediated by DNA hypermethylation its promoter, decreased associated with poor prognosis. Functionally, serving suppressor gene...
Senile osteoporosis is one of the major health problems in an aging society.Decreased bone formation due to osteoblast dysfunction may be causes aging-related loss.With increasing evidence suggesting that multiple microRNAs (miRNAs) play important roles function, relationship between miRNAs and senile has become a popular research topic.Previously, we confirmed mechanoresponsive miR-138-5p negatively regulated anabolic action.In this study, level was found correlated with BMD osteogenic...
Stroke is an acute disorder and dysfunction of the focal neurological system that has long been recognized as one leading causes death severe disability in most regions globally. This study aimed to supplement exploit multiple comorbidities, laboratory tests demographic factors more accurately predict related stroke, furthermore, make inferences about heterogeneity treatment stroke patients guide better planning.We extracted data from Medical Information Mart Intensive Care (MIMIC)-IV...
The decreased osteogenic differentiation ability of mesenchymal stem cells (MSCs) is one the important reasons for SOP. Inhibition Wnt signaling in MSCs closely related to Microtubule actin crosslinking factor 1 (MACF1) an regulator Wnt/β-catenin signal transduction. However, whether specific expression MACF1 MSC regulates SOP and its mechanism remains unclear. We established MSC-specific Prrx1 (Prx1) promoter-driven conditional knock-in (MACF-KI) mice, naturally aged male ovariectomized...
Excessive fructose diet is closely associated with colorectal cancer (CRC) progression. Nevertheless, fructose's specific function and precise mechanism in liver metastasis (CRLM) rarely known. Here, this study reported that the absorbed by primary could accelerate CRLM, expression of KHK-A, not KHK-C, was higher than paired tumors. Furthermore, KHK-A facilitated fructose-dependent CRLM vitro vivo phosphorylating PKM2 at Ser37. phosphorylated inhibited its tetramer formation pyruvic acid...
Emerging evidence is revealing that microRNAs (miRNAs) play essential roles in mechanosensing for regulating osteogenesis. However, no mechanoresponsive miRNAs have been identified human bone specimens. Methods: Bedridden and aged patients, hindlimb unloaded mice, Random Positioning Machine primary osteoblasts were adopted to simulate mechanical unloading conditions at the human, animal cellular levels, respectively. Treadmill exercise Flexcell cyclic stretching used loading vivo vitro,...
Although skeletal progenitors provide a reservoir for bone-forming osteoblasts, the major energy source their osteogenesis remains unclear. Here, we demonstrate requirement mitochondrial oxidative phosphorylation in osteogenic commitment and differentiation of progenitors. Deletion Evolutionarily Conserved Signaling Intermediate Toll pathways (ECSIT) hinders bone formation regeneration, resulting deformity, defects marrow niche spontaneous fractures followed by persistent nonunion. Upon...
Abstract Background Due to the heterogeneity of low‐grade gliomas (LGGs), lack randomized control trials, and strong clinical evidence, effect extent resection (EOR) is currently controversial. Aim To determine best choice between subtotal (STR) gross‐total (GTR) for individual patients identify features that are potentially relevant treatment heterogeneity. Methods Patients were enrolled from SEER database. We used a novel DL approach make recommendations with LGG. also made causal...
Abstract Tumor‐associated macrophages (TAMs) play a crucial role in promoting tumor growth and dissemination, motivating search for key targets to interfere with the activation of TAMs or reprogram into tumor‐suppressive type. To gain insight mechanisms macrophage polarization, designed co‐culture system is established, allowing education manner that closely mimics intricacies immune microenvironment (TIME). Through database mining, exosomal miR‐1246 identified then validated. Exosomal...