A5101568008- Bone Metabolism and Diseases
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Catalysis and Oxidation Reactions
- Catalytic Processes in Materials Science
- CRISPR and Genetic Engineering
- Mathematical and Theoretical Epidemiology and Ecology Models
- NF-κB Signaling Pathways
- Peptidase Inhibition and Analysis
- Bone health and treatments
- Brucella: diagnosis, epidemiology, treatment
- Extracellular vesicles in disease
- TGF-β signaling in diseases
- Systemic Lupus Erythematosus Research
- Bone health and osteoporosis research
- Circular RNAs in diseases
- interferon and immune responses
- Pregnancy-related medical research
- Scoliosis diagnosis and treatment
- Nanoparticle-Based Drug Delivery
- Biosensors and Analytical Detection
- Evolution and Genetic Dynamics
- Protein Degradation and Inhibitors
- Clostridium difficile and Clostridium perfringens research
Xinjiang University
2020-2025
Hong Kong Baptist University
2015-2021
Shenzhen Institute for Drug Control
2017
State Key Laboratory of Chemobiosensing and Chemometrics
2015
Hunan University
2015
Northwestern Polytechnical University
2015
Kunshan Industrial Technology Research Institute
2015
HKUST Shenzhen Research Institute
2015
Hohai University
2011
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs (miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However, whether miRNAs mediate osteoclast-directed formation is mostly unknown. Here, we show increased osteoclastic miR-214-3p associates with both elevated serum exosomal reduced elderly women fractures ovariectomized (OVX) mice. Osteoclast-specific knock-in mice rescued by osteoclast-targeted antagomir-214-3p treatment....
Paclitaxel (PTX) is among the most commonly used first-line drugs for cancer chemotherapy. However, its poor water solubility and indiscriminate distribution in normal tissues remain clinical challenges. Here we design synthesize a highly water-soluble nucleolin aptamer-paclitaxel conjugate (NucA-PTX) that selectively delivers PTX to tumor site. By connecting tumor-targeting aptamer (NucA) active hydroxyl group at 2' position of via cathepsin B sensitive dipeptide bond, NucA-PTX remains...
Abstract The role of osteoclastic miRNAs in regulating osteolytic bone metastasis (OBM) breast cancer is still underexplored. Here, we examined the expression profiles osteoclastogenic human specimens and identified that miR-214-3p was significantly upregulated patients with OBM. Consistently, found increased within osteoclasts, which associated elevated resorption, during development OBM xenografted nude mice (BCX). Furthermore, genetic ablation prevent Conditioned medium from MDA-MB-231...
Emerging evidence indicates that the dysregulation of protein ubiquitination plays a crucial role in aging-associated diseases. Smad-dependent canonical BMP signaling pathway is indispensable for osteoblastic bone formation, which could be disrupted by and subsequent proteasomal degradation Smad1/5, key molecules transduction. However, whether Smad1/5 responsible age-related formation reduction still underexplored. Pleckstrin homology domain-containing family O member 1 (PLEKHO1) previously...
Pd-based/SAC catalysts modified with 9-phenylcarbazole (PCz) achieved 99.9% C 2 H conversion and over 99% VCM selectivity minimal deactivation. PCz stabilized Pd( ii ) particles enhanced catalytic efficiency, as confirmed by DFT simulations.
Abstract The underlying mechanism of the reduced bone formation during development glucocorticoid-induced osteoporosis (GIO) remains unclear. Here, we found that highly expressed CKIP-1 together with lowly total and phosphorylated Smad1/5 in samples was accompanied by either serum markers GIO patients or decreased mice. In vitro studies showed could promote Smad1 ubiquitination to suppress Smad-dependent BMP signaling inhibit osteogenic differentiation mineral deposition MC3T3-E1 cells...
Abstract Falls in late postmenopausal women with osteopenia usually cause fractures severe consequences. This 36-month randomized, double-blind and placebo-controlled trial a 10-year observational follow-up study aimed to investigate the long-term effect of herbal formula Bushen Yijing Fang (BSYJF) on fall risk osteopenia. 140 (Femoral neck T-score, −2.5~−2 SD) were recruited randomized orally receive calcium carbonate 300 mg daily either BSYJF or placebo for 36 months. The was further...
Brucellosis is one of the major infective and contagious bacterial diseases among animals in pastoral areas some countries. In this paper, we introduce effect environment white noise spatial propagation process brucellosis, consider a stochastic two-patch brucellosis model. On hand, get existence uniqueness global positive solution to systems. other by using Lyapunov function theory obtain series threshold dynamics results, incorporating extinction disease, unique ergodic stationary...
The construction of test basin for enhanced observing all elements the hydrological cycle was described.In this water levels, soil moisture, rainfall, evaporation and other are observed based on four river channel flow stations, a moisture monitoring sites, small integrated weather station, set observation system rainfall station equipment. observational data collected transported to computer via GPRS .The focuses verification research basic theory ,which can provide an effective physical...
Abstract Osteoblasts participating in the inflammation regulation gradually obtain concerns. However, its role joint of rheumatoid arthritis (RA) is largely unknown. Pleckstrin homology domain-containing family O member 1 (PLEKHO1) was previously identified as a negative regulator osteogenic lineage activity. Here we demonstrated that PLEKHO1 highly expressed osteoblasts articular specimens from RA patients and inflammatory mice. Genetic deletion osteoblastic Plekho1 ameliorated mice with...