A5017212833- Genetics, Aging, and Longevity in Model Organisms
- GABA and Rice Research
- Mitochondrial Function and Pathology
- Fungal and yeast genetics research
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Coenzyme Q10 studies and effects
- Liver Disease Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
- Plant Gene Expression Analysis
- Pluripotent Stem Cells Research
- Circadian rhythm and melatonin
- Peroxisome Proliferator-Activated Receptors
- Genomics, phytochemicals, and oxidative stress
- Plant Stress Responses and Tolerance
- Phytochemicals and Antioxidant Activities
- Lipid metabolism and biosynthesis
McGill University
2023
Concordia University
2015-2020
Concordia University
2017-2018
Nonalcoholic steatohepatitis (NASH) is epidemiologically associated with obesity and diabetes can lead to liver cirrhosis hepatocellular carcinoma if left untreated. The intricate signaling pathways that orchestrate hepatocyte energy metabolism cellular stress, intrahepatic cell crosstalk, as well interplay between peripheral tissues remain elusive are crucial for the development of anti-NASH therapies. Herein, we reveal E3 ligase FBXW7 a key factor regulating hepatic catabolism, stress...
We discovered six plant extracts that increase yeast chronological lifespan to a significantly greater extent than any of the presently known longevity-extending chemical compounds. One these is most potent pharmacological intervention yet described. show each geroprotector which delays onset and decreases rate aging by eliciting hormetic stress response. also has different effects on cellular processes define longevity in organisms across phyla. These include following: 1) increased...
We have previously found that exogenously added lithocholic acid delays yeast chronological aging. demonstrated enters the cell, is sorted to mitochondria, resides in both mitochondrial membranes, changes relative concentrations of different membrane phospholipids, triggers many proteins, and alters some key aspects functionality. hypothesized acid-driven lipidome may a causal role remodeling proteome, which turn alter functional state mitochondria create pattern Here, we test this...
// Pamela Dakik 1 , Monica Enith Lozano Rodriguez Jennifer Anne Baratang Junio Darya Mitrofanova Younes Medkour Tala Tafakori Tarek Taifour Vicky Lutchman Eugenie Samson Anthony Arlia-Ciommo Belise Rukundo Éric Simard 2 and Vladimir I. Titorenko Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada Idunn Technologies Inc., Rosemere, J7A 4A5, Correspondence to: Titorenko, email: vladimir.titorenko@concordia.ca Keywords: cellular aging; longevity; gerotargets;...
// Younes Medkour 1 , Karamat Mohammad Anthony Arlia-Ciommo Veronika Svistkova Pamela Dakik Darya Mitrofanova Monica Enith Lozano Rodriguez Jennifer Anne Baratang Junio Tarek Taifour Paola Escudero Fani-Fay Goltsios Sahar Soodbakhsh Hana Maalaoui Éric Simard 2 and Vladimir I. Titorenko Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada Idunn Technologies Inc., Rosemere, J7A 4A5, Correspondence to: Titorenko, email: vladimir.titorenko@concordia.ca Keywords: cellular...
The yeast Saccharomyces cerevisiae is a unicellular eukaryote that has been successfully used as model organism for discovering signaling pathways and chemical compounds modulate cellular aging, define organismal lifespan, influence fitness not only in but also various multicellular eukaryotes. Using robust quantitative assay measuring chronological we discovered six plant extracts (PE; i.e. PE4, PE5, PE6, PE8, PE12 PE21) whose longevity‐extending efficiencies greatly exceed those of...
Exogenously added lithocholic bile acid (LCA) is known to extend the chronological lifespan of yeast Saccharomyces cerevisiae , accumulate in mitochondria and alter mitochondrial membrane lipidome. Using quantitative mass spectrometry, we demonstrated that LCA alters age‐related dynamics changes levels many proteins, as well numerous proteins cellular locations outside mitochondria. These belong two regulons, each modulated by a different dysfunction; call them partial dysfunction regulon an...
Caloric restriction (CR) and dietary (DR) extend lifespan across species improve health by delaying the onset of age‐related diseases. All currently known anti‐aging chemical compounds (1) mimic lifespan‐extending health‐improving effects CR DR without restricting caloric nutrient intake; (2) target signaling pathways that are under stringent control calorie and/or availability. It was believed therefore all longevity “adaptable” nature because they modulate only in response to certain...
The yeast Saccharomyces cerevisiae is a unicellular eukaryote that has been successfully used as model organism for discovering signaling pathways and chemical compounds modulate cellular aging, define organismal lifespan, influence fitness not only in but also various multicellular eukaryotes. Using robust quantitative assay measuring chronological we screened library of natural products to discover six plant extracts (PE; i.e. PE4, PE5, PE6, PE8, PE12 PE21) whose longevity‐extending...