A5069178263- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Renin-Angiotensin System Studies
- Sodium Intake and Health
- Circadian rhythm and melatonin
- Psoriasis: Treatment and Pathogenesis
- Neuroendocrine regulation and behavior
- Hormonal Regulation and Hypertension
- Neuroscience of respiration and sleep
- Diet, Metabolism, and Disease
- Heart Rate Variability and Autonomic Control
- Apelin-related biomedical research
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Eicosanoids and Hypertension Pharmacology
- Biochemical effects in animals
- Machine Learning in Bioinformatics
- Sulfur Compounds in Biology
- Molecular Sensors and Ion Detection
- Plant biochemistry and biosynthesis
- Dietary Effects on Health
- Speech Recognition and Synthesis
- RNA and protein synthesis mechanisms
- Genomics and Phylogenetic Studies
Xi'an Jiaotong University
2016-2025
National Medical Products Administration
2025
University of Science and Technology of China
2020-2024
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Second Affiliated Hospital of Zhejiang University
2024
Chengdu University of Technology
2023
Qilu Hospital of Shandong University
2007-2023
Sanya University
2023
Soochow University
2023
The genomic sequences of severe acute respiratory syndrome coronaviruses from human and palm civet the 2003/2004 outbreak in city Guangzhou, China, were nearly identical. Phylogenetic analysis suggested an independent viral invasion animal to this new episode. Combining all existing data but excluding singletons, we identified 202 single-nucleotide variations. Among them, 17 are polymorphic civets only. ratio nonsynonymous/synonymous nucleotide substitution collected 1 yr apart different...
BackgroundHyperactivity of the IL-23/IL-17 axis is central to plaque psoriasis pathogenesis. Secukinumab, a fully human mAb that selectively inhibits IL-17A, approved for treatment psoriasis, psoriatic arthritis, and ankylosing spondylitis. Secukinumab improves complete spectrum manifestations, with durable clinical responses beyond 5 years treatment. In feed-forward model chronicity, IL-17A has been hypothesized as key driver pathogenic gene expression by lesional keratinocytes, but in vivo...
Exercise (Ex) has long been recognized to produce beneficial effects on hypertension (HTN). This coupled with evidence of gut dysbiosis and an impaired gut-brain axis led us hypothesize that reshaping microbiota improvement in would, part, be associated influence exercise. Male spontaneously hypertensive rats (SHR) Wistar Kyoto (WKY) were randomized into sedentary, trained, detrained groups. Trained underwent moderate-intensity exercise for 12 weeks, whereas, groups 8 weeks followed by 4...
Luteolin is widely distributed among a number of vegetal species worldwide. The pharmacological effects luteolin are diverse and amongst antioxidant, free radical scavenging, anti-inflammatory activities. Preliminary study showed that can ameliorate hypertension. However, the precise mechanism needs further investigation. There no evidence affects paraventricular nucleus hypothalamus (PVN), brain associated with critical neural regulator blood pressure. Our main aim was to explore effect on...
A unique ruthenium(II) complex, tris(4-methyl-2,2′-bipyridyl-4′-carboxaldehyde)Ru(II) hexafluorophosphate [Ru(CHO-bpy)3](PF6)2, has been designed and synthesized as a highly sensitive selective luminescence probe for the recognition detection of cysteine (Cys) homocysteine (Hcy). The almost non-luminescent can rapidly react with Cys Hcy to yield corresponding thiazolidine thiazinane derivatives, accompanied by remarkable enhancement large blue-shift maximum emission wavelength from 720 635...
Aims Regular exercise as an effective non-pharmacological antihypertensive therapy is beneficial for prevention and control of hypertension, but the central mechanisms are unclear. In this study, we hypothesized that chronic training (ExT) delays progression hypertension attenuates cardiac hypertrophy by up-regulating anti-inflammatory cytokines, reducing pro-inflammatory cytokines (PICs) restoring neurotransmitters balance in hypothalamic paraventricular nucleus (PVN) young spontaneously...
Proinflammatory cytokines, including tumor necrosis factor (TNF)-α, augment the progression of heart failure (HF) that is characterized by sympathoexcitation. In this study, we explored role TNF-α in hypothalamic paraventricular nucleus (PVN) exaggerated sympathetic activity observed HF. Heart rats were made ligating left anterior descending coronary artery. The expression levels angiotensin type 1 receptor (AT1-R) and neurotransmitters analyzed PVN HF received direct infusion a blocker...
Inflammation has been implicated in the development of cardiovascular disease. We determined whether nod-like receptor with pyrin domain containing 3 (NLRP3) involved process prehypertension, central blockade NLRP3 decreased inflammation reaction, regulated neurohormonal excitation, and delayed progression prehypertension. Prehypertensive rats were induced by 8% salt diet. The on high-salt diet for 1 month administered a specific blocker hypothalamic paraventricular nucleus (PVN) 4 weeks....