A5101944548- Fatty Acid Research and Health
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Nanoplatforms for cancer theranostics
- Stress Responses and Cortisol
- Sodium Intake and Health
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Andrographolide Research and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Renin-Angiotensin System Studies
- Gut microbiota and health
- Cancer, Lipids, and Metabolism
- Inflammatory mediators and NSAID effects
- Hormonal Regulation and Hypertension
- Diet, Metabolism, and Disease
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Circadian rhythm and melatonin
- Inflammasome and immune disorders
- Birth, Development, and Health
Chung Shan Medical University
2016-2025
Chung Shan Medical University Hospital
2016-2025
Xi'an Jiaotong University
2016-2025
Nanjing Medical University
2019-2025
Heilongjiang University of Chinese Medicine
2025
National Medical Products Administration
2025
Chengdu University of Traditional Chinese Medicine
2025
Harbin University of Commerce
2025
Changzhou No.2 People's Hospital
2024-2025
State Key Laboratory of Food Science and Technology
2024
ABSTRACT Salt stress induced an increase in endogenous carbon monoxide (CO) production and the activity of CO synthetic enzyme haem oxygenase (HO) wheat seedling roots. In addition, a 50% aqueous solution, applied daily, not only resulted enhancement release, but led to significant reversal dry weight (DW) water loss caused by 150 m NaCl treatment, which was mimicked application two nitric oxide (NO) donors sodium nitroprusside (SNP) diethylenetriamine NO adduct (DETA/NO). Further analyses...
The genus Hiroshiinoueana Kawabe, 1978 is recorded from China for the first time. Two new species, H. wuzhishanica sp. nov. and inequivalva nov., are described illustrated. A key to species of provided. Cytochrome oxidase subunit I (COI) sequences deposited in GenBank.
Neuroinflammation is a crucial mechanism in many neurological disorders. Injury to the peripheral sensory nerves leads neuroinflammatory response somatosensory pathway, from dorsal root ganglia (DRG) spinal cord, contributing neuropathic pain. How immune reaction initiated peripherally and propagated cord remains less clear. Here, we find that ciliary neurotrophic factor (CNTF), highly expressed Schwann cells, mediates through activating signal transducer activator of transcription 3 (STAT3)...
Many neuroprotective approaches targeting neurons in animal models fail to provide benefits for the treatment of ischemic stroke clinic and glial cells have become targets some basic studies. Baicalin has effects but mechanisms related are not revealed. This study investigated whether how baicalin can combat excitotoxicity via protecting functions astrocytes early stage ischemia/reperfusion (I/R) insult by focusing on glutamine synthetase (GS). The role was explored primary exposed...
Abstract Tibial dyschondroplasia (TD) with multiple incentives is a metabolic skeletal disease that occurs in fast-growing broilers. Perturbations the gut microbiota (GM) have been shown to affect bone homoeostasis, but mechanisms by which GM modulates metabolism TD broilers remain unknown. Here, using broiler model of TD, we noted elevated blood glucose (GLU) levels broilers, accompanied alterations pancreatic structure and secretory function damaged intestinal barrier function....
Luteolin is widely distributed among a number of vegetal species worldwide. The pharmacological effects luteolin are diverse and amongst antioxidant, free radical scavenging, anti-inflammatory activities. Preliminary study showed that can ameliorate hypertension. However, the precise mechanism needs further investigation. There no evidence affects paraventricular nucleus hypothalamus (PVN), brain associated with critical neural regulator blood pressure. Our main aim was to explore effect on...
Aims: Extracellular vesicles from Lacticaseibacillus paracasei PC-H1 have antiproliferative activity of colon cells, but the effect on glycolytic metabolism cancer cell remains enigmatic. The authors investigated how extracellular (LpEVs) inhibit growth cells by affecting tumor metabolism. Materials & methods: HCT116 were treated with LpEVs and then differentially expressed genes analyzed transcriptome sequencing, sequencing results confirmed in vivo vitro. Results: entered inhibited their...
Colorectal cancer ( CRC ) accounts for over 600 000 deaths annually worldwide. The current study aims to evaluate the value of proto‐oncogene PIM 1 as a therapeutic target in and investigate anticancer activity hispidulin, naturally occurring phenolic flavonoid compound, against . Immunohistochemistry analysis showed that was upregulated tissue. role an oncogene evidenced by fact knockdown inhibits cell growth, induces apoptosis, suppresses invasion. Our results hispidulin exerts antitumor...
Traumatic injuries can trigger inflammatory reactions, leading to profound neuropathological consequences. However, the immune capacity of neurons, distinct from that cells or glial cells, in response traumatic insults remains be fully characterized. In this study, we demonstrate neurons detect, cell autonomously, distant axonal damage, resulting rapid production a specific collection cytokines and chemokines. This neuronal appears spatially temporally separated injury-induced axon...
IARC has classified the betel nut as a human environmental carcinogen. Previous studies have found that arecoline (AR) is major alkaloid present in saliva of quid chewers. Saliva contains large content AR which been further shown to cause mutation oral mucosa cells, resulting cancer. Whereas, date, there are only few reported hepatotoxicity associated with and chewing. Therefore, main purpose this study was determine toxic effects its oxidative metabolite, N-oxide (ARNO), normal liver cell...
Data from a number of researchers have shown that conjugated linoleic acid (CLA) has some beneficial health activities in animal models. Because inflammatory responses are associated with pathophysiology many diseases, the aim this study is to explore effect and mechanism CLA regulation lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. The addition increasing levels proportionally augmented incorporation cultures. diminished LPS-induced mRNA protein expression inducible nitric oxide...
Abstract Conjugated linoleic acid (CLA) is a chemoprotective fatty that inhibits phorbol ester-induced skin tumor promotion in mice. The goal of the present study was to determine potential mechanisms through which CLA may be acting. Mice were fed diets containing 0.0%, 0.5%, 1.0%, or 1.5% (by wt) for six weeks. epidermis evaluated composition, vascular permeability, prostaglandin E2; (PGE2) production, hyperplasia, ornithine decarboxylase activity, and c-myc mRNA accumulation. Fatty...
Diallyl trisulfide (DATS), diallyl sulfide (DAS), and disulfide (DADS) are the three major organosulfur compounds (OSCs) in garlic oil. In contrast to DADS DATS, evidence of an anti-inflammatory effect DATS is limited. this study compares efficacy with those DAS on lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression (NO) production RAW 264.7 macrophages. The NO LPS-activated macrophages was suppressed by both a dose-dependent manner. At 100 muM, nitrite levels...