A5101771495- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Plant-Microbe Interactions and Immunity
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Periodontal Regeneration and Treatments
- Circular RNAs in diseases
- Microbial Community Ecology and Physiology
- Cancer Mechanisms and Therapy
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- MicroRNA in disease regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Legume Nitrogen Fixing Symbiosis
- Toxic Organic Pollutants Impact
- Reproductive Biology and Fertility
- Studies on Chitinases and Chitosanases
- Pesticide Residue Analysis and Safety
- Polar Research and Ecology
- Neurological Disorders and Treatments
- Plant Pathogens and Fungal Diseases
- Adrenal Hormones and Disorders
- Cancer-related gene regulation
- Environmental and Social Impact Assessments
- Stress Responses and Cortisol
Nanjing Medical University
2019-2025
Suzhou Municipal Hospital
2024-2025
First Affiliated Hospital of Jiamusi University
2004-2025
Lanzhou University
2022-2024
Hebei University
2023
Zhejiang University
2022
Chinese PLA General Hospital
2020-2021
Ansteel (China)
2021
Huazhong University of Science and Technology
2020
State Council of the People's Republic of China
2020
Articular cartilage defect repair is a problem that has long plagued clinicians. Although mesenchymal stem cells (MSCs) have the potential to regenerate articular cartilage, they also many limitations. Recent studies found MSC-derived exosomes (MSC-Exos) play an important role in tissue regeneration. The purpose of this study was verify whether MSC-Exos can enhance reparative effect acellular extracellular matrix (ACECM) scaffold and explore underlying mechanism. results vitro experiments...
Accumulating evidence indicates that plant MYB transcription factors participate in defense against pathogen attack, but their regulatory targets and related signaling processes remain largely unknown. Here, we identified a defense-related gene (GhMYB108) from upland cotton (Gossypium hirsutum) characterized its functional mechanism. Expression of GhMYB108 plants was induced by Verticillium dahliae infection responded to the application molecules, including salicylic acid, jasmonic ethylene....
The apoplast serves as the first battlefield between plant hosts and invading microbes; therefore, work on plant-pathogen interactions has increasingly focused apoplastic immunity. In this study, we identified three proteins in of cotton (Gossypium sp) root cells during interaction with fungal pathogen Verticillium dahliae. Among these proteins, host secrete chitinase 28 (Chi28) Cys-rich repeat protein 1 (CRR1), while releases protease VdSSEP1. Biochemical analysis demonstrated that VdSSEP1...
Cartilage regeneration is a complex physiological process. Synovial macrophages play critical immunomodulatory role in the acute inflammatory response surrounding joint injury. Due to contrasting differences and heterogeneity of macrophage, phenotype are key determinants healing after cartilage Biomaterials derived from extracellular matrix have been used for repair reconstruction variety tissues by modulating host macrophage response. However, effect decellularized (ECM) on has not...
Recent reports indicate that decabromodiphenyl ethane (DBDPE) has become widespread in the environment. Yet databases regarding its bioavailability, biotransformation, and possible toxic effects to wildlife humans are lacking. In this study, we investigated bioconcentration biotransformation of DBDPE after oral exposure compared results with those decabrominated diphenyl ether (BDE-209) using rats as a model. Male were orally administrated corn oil containing 100 mg/kg bw/day or BDE-209 for...
Despite significant advances in the diagnosis and treatment of hepatocellular carcinoma (HCC), metastasis recurrence remain two major obstacles to improving clinical outcomes for HCC patients. Here, we demonstrate that splenic invariant natural killer T (iNKT) cells can significantly inhibit Hepa1-6-mediated intrahepatic metastasis. Interestingly, model, iNKT deficiency result a decrease percentage absolute number CD4+ cell interleukin-4 level, thus suggesting involvement cross-talk between...
Aims Regular exercise as an effective non-pharmacological antihypertensive therapy is beneficial for prevention and control of hypertension, but the central mechanisms are unclear. In this study, we hypothesized that chronic training (ExT) delays progression hypertension attenuates cardiac hypertrophy by up-regulating anti-inflammatory cytokines, reducing pro-inflammatory cytokines (PICs) restoring neurotransmitters balance in hypothalamic paraventricular nucleus (PVN) young spontaneously...
The microbiota of the female genital tract is crucial for reproductive health. This study aims to investigate impact lower on in vitro fertilization and frozen embryo transfer (IVF-FET) outcomes. included 131 women aged 20-35 years who underwent their first or second IVF-FET cycle with no obvious unfavorable factors implantation. Cervical samples were collected day analyzed using 16S rDNA full-length sequencing. Clinical outcomes followed up analysis. pregnancy (CP) was achieved 84 patients,...
Colorectal cancer (CRC) is a global public health issue with increasing prevalence. MicroRNA-934 (miR-934) kind of non-coding RNA involved in the regulation diverse cancers. Though previous researches have revealed part association between miR-934 and CRC, role CRC pathogenesis has not been completely explored yet. In this study, we aim to investigate effect on cell proliferation, migration, invasion angiogenesis CRC. Accordingly, was found be over-expressed SW480 HCT116 cells, two typical...
The alpine grassland ecosystem is a biodiversity hotspot of plants on the Qinghai-Tibetan Plateau, where rapid climate change altering patterns plant along elevational and seasonal gradients environments. However, how belowground microbial changes gradient during growing season not well understood yet. Here, we investigated distribution soil prokaryotic communities by using 16S rRNA amplicon sequencing an between 3,200 4,200 m, June September in grasslands. First, found diversity community...
Subgroup analysis has attracted growing attention due to its ability identify meaningful subgroups from a heterogeneous population and thereby improving predictive power. However, in many scenarios such as social science biology, the covariates are possibly highly correlated existence of common factors, which brings great challenges for group identification is neglected existing literature. In this paper, we aim fill gap ``diverging dimension" regime propose center-augmented subgroup method...
Phospholipases As (PLAs) are acyl hydrolases that catalyze the release of free fatty acids in phospholipids and play multiple functions plant growth development. The three families PLAs are: PLA1, PLA2 (sPLA), patatin-related PLA (pPLA). diverse pPLAs development a broad range plants have been demonstrated by prior studies.Genome-wide analysis pPLA gene family screening genes for expression verification silencing were conducted. Additionally, pollen vitality testing, pattern, detection POD,...
Oocytes are extremely sensitive to radiation and chemotherapy, premature ovarian failure (POF) is one of the side effects anti-tumor therapy. The pathogenesis POF very complex still not fully elucidated. A mouse model was established after 14 days cyclophosphamide injection. mice presented atrophy, destroyed follicular structure, a reduction in number primordial mature follicles, an decrease corpora luteal along with increased level follicle-stimulating hormone (FSH), decreased levels...