A5070148419- Polymer crystallization and properties
- Material Dynamics and Properties
- Organic Electronics and Photovoltaics
- Conducting polymers and applications
- Graphene research and applications
- Advanced Sensor and Energy Harvesting Materials
- Cancer-related molecular mechanisms research
- Advanced Materials and Mechanics
- Block Copolymer Self-Assembly
- RNA modifications and cancer
- Polymer Nanocomposites and Properties
- Theoretical and Computational Physics
- Advanced Cellulose Research Studies
- MicroRNA in disease regulation
- Force Microscopy Techniques and Applications
- Perovskite Materials and Applications
- Circular RNAs in diseases
- Liquid Crystal Research Advancements
- Adhesion, Friction, and Surface Interactions
- Carbon Nanotubes in Composites
- Advanced Photocatalysis Techniques
- Rheology and Fluid Dynamics Studies
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
Iowa State University
2023-2025
Hubei University of Technology
2025
Jiangsu Cancer Hospital
2015-2024
Nanjing Medical University
2015-2024
North Dakota State University
2018-2024
Second Affiliated Hospital of Nanjing Medical University
2015-2024
Hangzhou Medical College
2017-2024
Zhejiang Provincial People's Hospital
2017-2024
China University of Geosciences (Beijing)
2023-2024
Zhejiang A & F University
2024
Metabolic reprogramming is a hallmark of cancer cells and used by for growth survival. Pyruvate kinase muscle isozyme M2 (PKM2) limiting glycolytic enzyme that catalyzes the final step in glycolysis, which key tumor metabolism growth. The present review discusses expression regulation PKM2, reports dominant role PKM2 plays glycolysis to achieve nutrient demands cell proliferation. In addition, study non-metabolic function its as coactivator protein kinase, contributes tumorigenesis....
γδT cells have been reported to exert immunosuppressive functions in multiple solid malignant diseases, but their functional subpopulation breast cancer (BC) is still undetermined. Here, we collected 40 paired BC and normal tissue samples from Chinese patients for analysis. First, showed that γδT1 comprise the majority of CD3+ T BC; next, found CD73+γδT1 were predominant regulatory T-cell (Treg) population BC, prevalence peripheral blood was also related tumour burden. In addition, an effect...
Understanding the deformation mechanisms in multilayer graphene (MLG), an attractive material used nanodevices as well reinforcement of nanocomposites, is critical yet challenging due to difficulties experimental characterization and spatiotemporal limitations atomistic modeling. In this study, we combine nanomechanical experiments with coarse-grained molecular dynamics (CG-MD) simulations elucidate failure MLG sheets. Elastic properties sheets one three layers are measured using film...
Aberrant expression of circular RNAs (circRNAs) is involved in cancer progression through interaction with RNA-binding proteins (RBPs). Herein, we screened circRNA A549 cells circBase and the crosslinking immunoprecipitation (CLIP) data human antigen R (HuR), an extensively studied RBP, identified a circRNA, circ-defective cullin neddylation 1 domain containing 4 (circDCUN1D4), originating from DCUN1D4 gene transcript. circDCUN1D4 downregulated tumor samples under mediation DExH-box helicase...
The bottom-up prediction of the properties polymeric materials based on molecular dynamics simulation is a major challenge in soft matter physics. Coarse-grained (CG) models are often employed to access greater spatiotemporal scales required for many applications, but these normally experience significantly altered thermodynamics and highly accelerated due reduced number degrees freedom upon coarse-graining. While CG can be calibrated meet certain at particular state points, there...
Abstract Long noncoding RNAs (lncRNAs) are known to regulate the development and progression of various cancers. However, few lncRNAs have been well characterized in lung adenocarcinoma (LUAD). Here, we identified expression profile protein-coding genes via microarrays analysis paired LUAD tissues adjacent non-tumor from five female non-smokes with LUAD. A total 498 1691 were differentially expressed between normal tissues. novel lncRNA, transcript 1 (LUADT1), which is highly correlates T...
Predicting the macroscopic fracture energy of highly cross-linked glassy polymers from atomistic simulations is challenging due to size process zone being large in these systems. Here, we present a scale-bridging approach that links molecular dynamics properties on basis continuum mechanics model for two different epoxy materials. Our reveals resins strongly depends functionality resin and component ratio between curing agent (amine) epoxide. The most intriguing part our study demonstrate...
We present a versatile systematic two-bead-per-monomer coarse-grain modeling strategy for simulating the thermomechanical behavior of methacrylate polymers at length and time scales far exceeding atomistic simulations. establish generic bonded interaction parameters via Boltzmann inversion probability distributions obtained from common bead center locations five different polymers. Distinguishing features each monomer side-chain group are captured using Lennard-Jones nonbonded potentials...
Exercise (Ex) has long been recognized to produce beneficial effects on hypertension (HTN). This coupled with evidence of gut dysbiosis and an impaired gut-brain axis led us hypothesize that reshaping microbiota improvement in would, part, be associated influence exercise. Male spontaneously hypertensive rats (SHR) Wistar Kyoto (WKY) were randomized into sedentary, trained, detrained groups. Trained underwent moderate-intensity exercise for 12 weeks, whereas, groups 8 weeks followed by 4...
Studies have indicated the significance of tumor associated macrophages (TAMs) in breast cancer; however, inconsistent results still exist. We retrospectively reviewed macrophage distribution 1579 cancer specimens with anti-CD68 or anti-CD163 immunohistochemical staining, and further analyzed overall survival data. Furthermore, we performed a retrospective study systematic review published studies on CD68- CD163-positive non-metastatic cancer. 13 5116 patients were included this...
Predicting the glass transition temperature (Tg) is of critical importance as it governs thermomechanical performance conjugated polymers (CPs). Here, we report a predictive modeling framework to predict Tg CPs through integration machine learning (ML), molecular dynamics (MD) simulations, and experiments. With 154 data collected, an ML model developed by taking simplified "geometry" six chemical building blocks features, where side-chain fraction, isolated rings, fused bridged rings...
Abstract Background Lung adenocarcinoma (LUAD) is the leading cause of death worldwide. However, roles long noncoding RNAs (lncRNAs) hijacked by super-enhancers (SEs), vital regulatory elements epigenome, remain elusive in progression LUAD metastasis. Methods SE-associated lncRNA microarrays were used to identify dysregulated lncRNAs LUAD. ChIP-seq, Hi-C data analysis, and luciferase reporter assays utilized confirm hijacking LINC01977 SE. The functions mechanisms explored a series vitro...
To develop structure–property relationships for cross-linked thermosetting polymers, it is crucial to better understand key factors that control their segmental dynamics and macroscopic properties. Here, we employ a coarse-grained (CG) polymer model systematically explore the combined effect of varying cohesive energy (ε) cross-link density (c) on relaxation time mechanical properties glass-forming thermoset material. We find increasing c increases both glass transition temperature Tg...
The dispersion of graphene sheets within a polymer matrix is critical for the performance graphene-reinforced nanocomposites, particularly in achieving optimal percolation and electrical conductivity. However, accurately characterizing controlling 2D melts remains significant challenge due to complex varied configurations that can adopt. Herein, we employ coarse-grained molecular dynamics simulations investigate how grafting density (g) grafted chain length (n) poly(methyl methacrylate),...
Cellulose nanocrystals (CNCs) exhibit impressive interfacial and mechanical properties that make them promising candidates to be used as fillers within nanocomposites. While glass-transition temperature (Tg) is a common metric for describing thermomechanical properties, its prediction extremely difficult it depends on filler surface chemistry, volume fraction, size. Here, taking CNC-reinforced poly(methyl-methacrylate) (PMMA) nanocomposites relevant model system, we present multiscale...
We present a systematic, two-bead per monomer coarse-graining strategy allowing for the prediction of thermomechanical behavior polystyrene. Analytical bonded potentials optimized to match atomistic distributions different stereochemistries emulate local structure. Alternatively, backbone torsional potential is leveraged chain stiffness in direct approach. Nonbonded using temperature-dependent density correction term demonstrate transferability modulus. Flory–Fox constants Tg-optimized CG...
Multiscale coarse-grained (CG) modeling of soft materials, such as polymers, is currently an art form because CG models normally have significantly altered dynamics and thermodynamic properties compared to their atomistic counterparts. We address this problem by exploiting concepts derived from the generalized entropy theory (GET), emphasizing central role configurational sc in complex fluids. Our energy renormalization (ER) method involves varying cohesive interaction strength a way that...